OSCR

Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1).

Overview

Authors: Jian Yin1, Sensen Zhang2, Chang Liu2, Min Xie1, Yuanzhu Gao3, Maofei Chen1, Yixue Wang1, Meiying Chen1, Hongxuan Fan4, Zi Yang5, Huan Li6, Li Liang7, Boda Zhou4, Xudong Chen1, Maojun Yang1,2
ORCID iDs: Sensen Zhang, Maofei Chen, Yixue Wang, Hongxuan Fan, Huan Li, Boda Zhou, Xudong Chen, Maojun Yang
  1. State Key Laboratory of Membrane Biology, Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University,Beijing, China
  2. Beijing Life Science Academy, Beijing, China
  3. Cryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen,Guangdong, China
  4. Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University,Beijing, China
  5. Technology Center for Protein Research, School of Life Sciences, Tsinghua University,Beijing, China
  6. School of Basic Medical Sciences, Capital Medical University‌,Beijing, China
  7. Department of Stomatology, Eighth Medical Center of Chinese PLA General Hospital,Beijing, China
Institutions: State Key Laboratory of Membrane Biology; Southern University of Science and Technology (China); Tsinghua University (China); Capital Medical University (China); Chinese PLA General Hospital (China)
Journal: Nature communications, volume 17, issue 1, article 8383
Dates: received 14 May 2025; accepted 26 June 2026; published online 7 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-75306-z · PMID 42414312 · PMCID PMC13473456 · OpenAlex W7167616485
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: histology / microscopy (modality), human (organism), cellular / molecular (subfield)
Methods: Statistics, fMRI & imaging
Keywords: Cryoelectron microscopy, Membrane proteins, Computational biophysics
MeSH: Amino Acid Transport Systems*, Symporters*, Binding Sites, Biological Transport, Cryoelectron Microscopy, Cycloserine, Humans, Ligands, Models, Molecular, Protons, Serine, Substrate Specificity (* major topic)
Topic: Amino Acid Enzymes and Metabolism (Biochemistry, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (32571390, 32030056); Southern University of Science and Technology
Citations: not cited yet (Europe PMC); 80 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-75306-z.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Funding: added National Natural Science Foundation of China: 32571390, 32030056; Southern University of Science and Technology

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 3 keywords, 12 MeSH terms, 77 references.

Cite

This paper

Yin, J., Zhang, S., Liu, C., Xie, M., Gao, Y., Chen, M., Wang, Y., Chen, M., Fan, H., Yang, Z., Li, H., Liang, L., Zhou, B., Chen, X., & Yang, M. (2026). Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1). Nature communications, 17(1), 8383. https://doi.org/10.1038/s41467-026-75306-z

BibTeX

@article{yin2026substrate,
author = {Yin, Jian and Zhang, Sensen and Liu, Chang and Xie, Min and Gao, Yuanzhu and Chen, Maofei and Wang, Yixue and Chen, Meiying and Fan, Hongxuan and Yang, Zi and Li, Huan and Liang, Li and Zhou, Boda and Chen, Xudong and Yang, Maojun},
title = {{Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1)}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {8383},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75306-z},
url = {https://doi.org/10.1038/s41467-026-75306-z},
pmid = {42414312},
pmcid = {PMC13473456}
}

RIS

TY - JOUR
AU - Yin, Jian
AU - Zhang, Sensen
AU - Liu, Chang
AU - Xie, Min
AU - Gao, Yuanzhu
AU - Chen, Maofei
AU - Wang, Yixue
AU - Chen, Meiying
AU - Fan, Hongxuan
AU - Yang, Zi
AU - Li, Huan
AU - Liang, Li
AU - Zhou, Boda
AU - Chen, Xudong
AU - Yang, Maojun
TI - Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1)
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/07
VL - 17
IS - 1
SP - 8383
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75306-z
UR - https://doi.org/10.1038/s41467-026-75306-z
LA - en
ER -

CSL-JSON

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