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Dynamic interactions between epithelial skin cells and a sensory cavity sculpt the growing olfactory orifice.

Overview

Authors: Clara Gordillo Pi1,2,3, Mélody Cabrera1,2, Jean-François Gilles2,4, Pierre-Luc Bardet1,2, Alexis Eschstruth1,2, Isabelle Bonnet3, Marie Anne Breau1,2, Marion Baraban1,2
ORCID iDs: Alexis Eschstruth, Isabelle Bonnet, Marion Baraban
  1. CNRS, INSERM, Development, Adaptation and Ageing, Dev2A, Sorbonne Université,Paris, France
  2. CNRS, INSERM, Institut de Biologie Paris-Seine, IBPS, Sorbonne Université,Paris, France
  3. Institut Curie, CNRS UMR168, Physics of Cells and Cancer, Université PSL, Sorbonne Université,Paris, France
  4. Imaging Facility, Institut de Biologie Paris-Seine (IBPS),Paris, France
Institutions: Sorbonne Université (France); Institut de Biologie Paris-Seine (France)
Journal: Nature communications, volume 17, issue 1, article 8452
Dates: received 25 July 2025; accepted 25 June 2026; published online 8 July 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1038/s41467-026-75307-y · PMID 42420278 · PMCID PMC13478634 · OpenAlex W4412744497
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.07.25.666761
Status: code on request
Categories: zebrafish (organism), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials, fMRI & imaging
Keywords: Morphogenesis, Organogenesis, Pattern formation
MeSH: Epithelial Cells*, Nasal Cavity*, Olfactory Mucosa*, Skin*, Actomyosin, Animals, Ectodermal Placodes, Morphogenesis, Zebrafish (* major topic)
Topic: Olfactory and Sensory Function Studies (Sensory Systems, Neuroscience), according to OpenAlex
Funding: Agence Nationale de la Recherche (French National Research Agency) (ANR-23-CE13-0025 MECAMATRIX, ANR-25-CE13-0203-01 OPEN); National Institute on Deafness and Other Communication Disorders (R01-DC-017989); Institut National de la Santé et de la Recherche Médicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Sorbonne Université
Citations: not cited yet (Europe PMC); 77 references in the paper

Abstract

During morphogenesis and in pathological conditions, gaps can form in the plane of epithelial barriers upon cellular forces that disrupt intercellular junctions. How the size of these epithelial holes further increases over time and what sets their shape remain poorly understood. Here we analyze the formation of the olfactory orifice (the nostril) in zebrafish, which opens and grows in the skin epithelium above a rosette of olfactory placode cells, allowing the sensory neurons to directly access odor cues. Using quantitative imaging and tissue-specific perturbations, we analyze the dynamic remodeling of skin cells allowing the expansion of the orifice edge. We identify the sensory cavity located in the center of the placodal rosette as a crucial player that sets the size of the growing epithelial hole in the skin. We further show that fine-tuning of actomyosin contractility within each tissue (skin and sensory cavity) exerts non-autonomous effects on the neighboring tissue, thereby shaping the nostril structure. This study uncovers dynamic cell behaviors and reciprocal tissue-tissue interplay that control the growth and shape of an epithelial hole in vivo.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability

The custom code used in this article will be made available upon request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Tracing map

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Data

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Data availability

Data supporting the findings of this study are available within the paper and its Supplementary Information files. All other relevant data are available from the authors upon request. Source data are provided with this paper.

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Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 3 keywords, 9 MeSH terms, 5 funders, 76 references.

Cite

This paper

Gordillo Pi, C., Cabrera, M., Gilles, J.-F., Bardet, P.-L., Eschstruth, A., Bonnet, I., Breau, M. A., & Baraban, M. (2026). Dynamic interactions between epithelial skin cells and a sensory cavity sculpt the growing olfactory orifice. Nature communications, 17(1), 8452. https://doi.org/10.1038/s41467-026-75307-y

BibTeX

@article{gordillopi2026dynamic,
author = {Gordillo Pi, Clara and Cabrera, Mélody and Gilles, Jean-François and Bardet, Pierre-Luc and Eschstruth, Alexis and Bonnet, Isabelle and Breau, Marie Anne and Baraban, Marion},
title = {{Dynamic interactions between epithelial skin cells and a sensory cavity sculpt the growing olfactory orifice}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {8452},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75307-y},
url = {https://doi.org/10.1038/s41467-026-75307-y},
pmid = {42420278},
pmcid = {PMC13478634}
}

RIS

TY - JOUR
AU - Gordillo Pi, Clara
AU - Cabrera, Mélody
AU - Gilles, Jean-François
AU - Bardet, Pierre-Luc
AU - Eschstruth, Alexis
AU - Bonnet, Isabelle
AU - Breau, Marie Anne
AU - Baraban, Marion
TI - Dynamic interactions between epithelial skin cells and a sensory cavity sculpt the growing olfactory orifice
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/08
VL - 17
IS - 1
SP - 8452
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75307-y
UR - https://doi.org/10.1038/s41467-026-75307-y
LA - en
ER -

CSL-JSON

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