OSCR

Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy.

Overview

Authors: Kun Zhang1,2, Dake Song1,3, Yingying Zhang1,4, Le Yang4, Ban Feng5, Ruixia Liu1,3, Hengxin Gong1,2, Longbiao Cui6, Shanbo Ma7, Yanwei Chen8, Min Wang1,2, Xinshang Wang1,4, Yumei Wu1,2, Ting Bai9, Kun Xia9, Minggao Zhao1,4, Shuibing Liu1,3
ORCID iDs: Kun Zhang, Longbiao Cui, Yumei Wu, Kun Xia, Shuibing Liu
  1. Department of Pharmacology, School of Pharmacy, Fourth Military Medical University,Xi’an, Shaanxi China
  2. Key Laboratory of Gastrointestinal Pharmacology of Chinese Material Medical of the State Administration of Traditional Chinese Medicine, Xi’an, Shaanxi China
  3. State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, School of Stomatology, Fourth Military Medical University,Xi’an, Shaanxi China
  4. Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University,Xi’an, Shaanxi China
  5. Shanghai Key Laboratory of Anaesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anaesthesiology and Perioperative Medicine, Department of Anaesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University,Shanghai, China
  6. Department of Clinical Psychology, School of Medical Psychology, Fourth Military Medical University,Xi’an, Shaanxi China
  7. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University,Xi’an, Shaanxi China
  8. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University,Xi’an, Shaanxi China
  9. Hunan Key Laboratory of Medical Genetics, Hunan Key Laboratory of Animal Models for Human Diseases, MOE Key Lab of Rare Pediatric Diseases, Center for Medical Genetics, School of Life Sciences, Central South University,Changsha, Hunan China
Institutions: Air Force Medical University (China); Tongji University (China); Central South University (China)
Journal: Nature communications, volume 17, issue 1, article 8774
Dates: received 21 July 2025; accepted 1 July 2026; published online 17 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-75424-8 · PMID 42469218 · PMCID PMC13493774 · OpenAlex W7169534599
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), depression (population)
Methods: Statistics
Keywords: Empathy, Prefrontal cortex, Molecular neuroscience
MeSH: Depression*, Empathy*, Neurons*, Prefrontal Cortex*, Animals, Astrocytes, Behavior, Animal, Disease Models, Animal, Male, Mice, Mice, Inbred C57BL (* major topic)
Topic: Urinary Bladder and Prostate Research (Urology, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 79 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-75424-8.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 3 keywords, 11 MeSH terms, 79 references.

Cite

This paper

Zhang, K., Song, D., Zhang, Y., Yang, L., Feng, B., Liu, R., Gong, H., Cui, L., Ma, S., Chen, Y., Wang, M., Wang, X., Wu, Y., Bai, T., Xia, K., Zhao, M., & Liu, S. (2026). Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy. Nature communications, 17(1), 8774. https://doi.org/10.1038/s41467-026-75424-8

BibTeX

@article{zhang2026major,
author = {Zhang, Kun and Song, Dake and Zhang, Yingying and Yang, Le and Feng, Ban and Liu, Ruixia and Gong, Hengxin and Cui, Longbiao and Ma, Shanbo and Chen, Yanwei and Wang, Min and Wang, Xinshang and Wu, Yumei and Bai, Ting and Xia, Kun and Zhao, Minggao and Liu, Shuibing},
title = {{Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {8774},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75424-8},
url = {https://doi.org/10.1038/s41467-026-75424-8},
pmid = {42469218},
pmcid = {PMC13493774}
}

RIS

TY - JOUR
AU - Zhang, Kun
AU - Song, Dake
AU - Zhang, Yingying
AU - Yang, Le
AU - Feng, Ban
AU - Liu, Ruixia
AU - Gong, Hengxin
AU - Cui, Longbiao
AU - Ma, Shanbo
AU - Chen, Yanwei
AU - Wang, Min
AU - Wang, Xinshang
AU - Wu, Yumei
AU - Bai, Ting
AU - Xia, Kun
AU - Zhao, Minggao
AU - Liu, Shuibing
TI - Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/17
VL - 17
IS - 1
SP - 8774
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75424-8
UR - https://doi.org/10.1038/s41467-026-75424-8
LA - en
ER -

CSL-JSON

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