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Cooperative mechanism of neurotransmitter recognition and transport by the human vesicular polyamine transporter.

Overview

Authors: Yi Guo1, Ge Yang2, Jin Chai3, John Shanklin3, Bin Liu2, Min Lu1
  1. Center for Proteomics & Molecular Therapeutics, Rosalind Franklin University of Medicine & Science, North Chicago, IL USA
  2. The Hormel Institute, University of Minnesota, Austin, MN USA
  3. Biology Department, Brookhaven National Laboratory, Upton, NY USA
Journal: Nature communications, volume 17, issue 1, article 8704
Dates: received 19 November 2025; accepted 1 July 2026; published online 16 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-75564-x · PMID 42463709 · PMCID PMC13490608 · OpenAlex W7168666680
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: histology / microscopy (modality), human (organism), cellular / molecular (subfield)
Methods: Statistics, fMRI & imaging
Keywords: Cryoelectron microscopy, Ion transport, Ion channels
MeSH: Antiporters*, Histamine*, Neurotransmitter Agents*, Serotonin*, Binding Sites, Biological Transport, Cryoelectron Microscopy, Humans, Liposomes, Models, Molecular, Polyamines, Protein Binding (* major topic)
Topic: Polyamine Metabolism and Applications (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R01GM145642); U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) (R01GM145642); NIGMS NIH HHS (R01 GM145642)
Citations: not cited yet (Europe PMC); 55 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-75564-x.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 3 keywords, 12 MeSH terms, 3 funders, 54 references.

Cite

This paper

Guo, Y., Yang, G., Chai, J., Shanklin, J., Liu, B., & Lu, M. (2026). Cooperative mechanism of neurotransmitter recognition and transport by the human vesicular polyamine transporter. Nature communications, 17(1), 8704. https://doi.org/10.1038/s41467-026-75564-x

BibTeX

@article{guo2026cooperative,
author = {Guo, Yi and Yang, Ge and Chai, Jin and Shanklin, John and Liu, Bin and Lu, Min},
title = {{Cooperative mechanism of neurotransmitter recognition and transport by the human vesicular polyamine transporter}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {8704},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75564-x},
url = {https://doi.org/10.1038/s41467-026-75564-x},
pmid = {42463709},
pmcid = {PMC13490608}
}

RIS

TY - JOUR
AU - Guo, Yi
AU - Yang, Ge
AU - Chai, Jin
AU - Shanklin, John
AU - Liu, Bin
AU - Lu, Min
TI - Cooperative mechanism of neurotransmitter recognition and transport by the human vesicular polyamine transporter
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/16
VL - 17
IS - 1
SP - 8704
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75564-x
UR - https://doi.org/10.1038/s41467-026-75564-x
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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}

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