OSCR

Imaging and genome-supported association of glymphatic system function and multiregional brain characteristics with Parkinson's disease.

Overview

Authors: Zhinan Ye1, Yuchen Lin2, Yangguang Lu2, Zihao Wu2, Baoyi Zhu3, Qiaoqiao Jin2, Yang Zhang2, Zhuoyu Chen4, Xinyi Yuan2, Zihan Yuan4, Ziyu Yang2, Suwen Huang5, Yiyun Weng5, Dehao Yang6
ORCID iDs: Yangguang Lu
  1. Department of Neurology, Taizhou Municipal Hospital,Taizhou, China
  2. The First School of Medicine, School of Information and Engineering, Wenzhou Medical University,Wenzhou, China
  3. The School of Mental Health, Wenzhou Medical University,Wenzhou, China
  4. The Second School of Medicine, Wenzhou Medical University,Wenzhou, China
  5. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, China
  6. Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine,Hangzhou, China
Institutions: Taizhou Municipal Hospital (China); Wenzhou Medical University (China); First Affiliated Hospital of Wenzhou Medical University (China); Second Affiliated Hospital of Zhejiang University (China)
Journal: NPJ Parkinson's disease, volume 12, issue 1, article 103
Dates: received 17 October 2025; accepted 26 February 2026; published online 12 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41531-026-01314-x · PMID 41820405 · PMCID PMC13121599 · OpenAlex W7135098901
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: Parkinson's (population)
Methods: Connectivity, Statistics, Machine learning, fMRI & imaging
Keywords: Diseases, Neurology, Neuroscience
Topic: Cerebrospinal fluid and hydrocephalus (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Science and Technology Plan Project of Taizhou (25ywb102); National Undergraduate Innovation and Entrepreneurship Training Program of China (202510343038); Zhejiang Provincial Natural Science Foundation of China (LQ24H090003); National Natural Science Foundation of China (82302081)
Citations: not cited yet (Europe PMC); 33 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41531-026-01314-x.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41531-026-01314-x.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 3 keywords, 4 funders, 33 references.

Cite

This paper

Ye, Z., Lin, Y., Lu, Y., Wu, Z., Zhu, B., Jin, Q., Zhang, Y., Chen, Z., Yuan, X., Yuan, Z., Yang, Z., Huang, S., Weng, Y., & Yang, D. (2026). Imaging and genome-supported association of glymphatic system function and multiregional brain characteristics with Parkinson's disease. NPJ Parkinson's disease, 12(1), 103. https://doi.org/10.1038/s41531-026-01314-x

BibTeX

@article{ye2026imaging,
author = {Ye, Zhinan and Lin, Yuchen and Lu, Yangguang and Wu, Zihao and Zhu, Baoyi and Jin, Qiaoqiao and Zhang, Yang and Chen, Zhuoyu and Yuan, Xinyi and Yuan, Zihan and Yang, Ziyu and Huang, Suwen and Weng, Yiyun and Yang, Dehao},
title = {{Imaging and genome-supported association of glymphatic system function and multiregional brain characteristics with Parkinson's disease}},
journal = {NPJ Parkinson's disease},
year = {2026},
month = mar,
volume = {12},
number = {1},
pages = {103},
publisher = {Nature Publishing Group},
issn = {2373-8057},
doi = {10.1038/s41531-026-01314-x},
url = {https://doi.org/10.1038/s41531-026-01314-x},
pmid = {41820405},
pmcid = {PMC13121599}
}

RIS

TY - JOUR
AU - Ye, Zhinan
AU - Lin, Yuchen
AU - Lu, Yangguang
AU - Wu, Zihao
AU - Zhu, Baoyi
AU - Jin, Qiaoqiao
AU - Zhang, Yang
AU - Chen, Zhuoyu
AU - Yuan, Xinyi
AU - Yuan, Zihan
AU - Yang, Ziyu
AU - Huang, Suwen
AU - Weng, Yiyun
AU - Yang, Dehao
TI - Imaging and genome-supported association of glymphatic system function and multiregional brain characteristics with Parkinson's disease
T2 - NPJ Parkinson's disease
J2 - NPJ Parkinsons Dis
PY - 2026
DA - 2026/03/12
VL - 12
IS - 1
SP - 103
SN - 2373-8057
PB - Nature Publishing Group
DO - 10.1038/s41531-026-01314-x
UR - https://doi.org/10.1038/s41531-026-01314-x
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41531-026-01314-x",
"type": "article-journal",
"title": "Imaging and genome-supported association of glymphatic system function and multiregional brain characteristics with Parkinson's disease",
"container-title": "NPJ Parkinson's disease",
"author": [
{
"family": "Ye",
"given": "Zhinan"
},
{
"family": "Lin",
"given": "Yuchen"
},
{
"family": "Lu",
"given": "Yangguang"
},
{
"family": "Wu",
"given": "Zihao"
},
{
"family": "Zhu",
"given": "Baoyi"
},
{
"family": "Jin",
"given": "Qiaoqiao"
},
{
"family": "Zhang",
"given": "Yang"
},
{
"family": "Chen",
"given": "Zhuoyu"
},
{
"family": "Yuan",
"given": "Xinyi"
},
{
"family": "Yuan",
"given": "Zihan"
},
{
"family": "Yang",
"given": "Ziyu"
},
{
"family": "Huang",
"given": "Suwen"
},
{
"family": "Weng",
"given": "Yiyun"
},
{
"family": "Yang",
"given": "Dehao"
}
],
"container-title-short": "NPJ Parkinsons Dis",
"volume": "12",
"issue": "1",
"page": "103",
"DOI": "10.1038/s41531-026-01314-x",
"PMID": "41820405",
"PMCID": "PMC13121599",
"ISSN": "2373-8057",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41531-026-01314-x",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
12
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1016/j.stemcr.2026.102830
Selective Ca<sub>v</sub>1.3 inhibition promotes survival of transplanted dopaminergic neurons via the CaMKII-p65-p53 pathway.
Journal: Stem cell reports
In common: Parkinson's, 3 references
[2] doi:10.1371/journal.pcbi.1014422 [code]
Deciphering cell type-specific causal genetic effects on brain imaging-derived phenotypes and disorders with single-cell Mendelian randomization.
Journal: PLoS computational biology
In common: 3 references
[3] doi:10.1002/hbm.70635 [code]
Cerebral Cortical Structural Variation and General Cognitive Ability: Evidence From Mendelian Randomization.
Journal: Human brain mapping
In common: 3 references
[4] doi:10.1002/alz.71630 [code]
Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
In common: 3 references
[5] doi:10.1097/md.0000000000050109
The gut-immune-brain axis in CNS tumors: Causal roles of microbiota and inflammatory proteins unveiled by Mendelian randomization and single-cell transcriptomics.
Journal: Medicine
In common: 3 references
[6] doi:10.1038/s43587-026-01106-1 [code]
Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization.
Journal: Nature aging
In common: 3 references
[7] doi:10.1186/s10194-026-02313-2
Elucidating biopsychosocial mechanisms in migraine: an integrative analytics approach combining genetics, neuroimaging, and machine learning.
Journal: The journal of headache and pain
In common: 3 references
[8] doi:10.1002/ana.78252 [code]
Diffusion MRI and α-Synuclein Seed Amplification Status in Parkinson's Disease.
Journal: Annals of neurology
In common: Parkinson's, 2 references
[9] doi:10.1016/j.prdoa.2026.100458
Timing of device-aided therapy initiation in Parkinson's disease: reference estimates for healthcare planning and biological heterogeneity.
Journal: Clinical parkinsonism & related disorders
In common: Parkinson's, 2 references
[10] doi:10.1038/s41591-026-04525-0
Human embryonic stem cell-derived dopaminergic cells for Parkinson's disease: a phase 1/2 open-label trial.
Journal: Nature medicine
In common: Parkinson's, 2 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.