In-vivo histology of Parkinson's disease using quantitative multiparametric mapping.

Overview

1. Section of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
2. Center for Brain, Behaviour, and Metabolism, University of Lübeck, Lübeck, Germany
3. Institute of Medical Psychology, University of Lübeck, Lübeck, Germany
4. Institute of Neurogenetics, University of Lübeck, Lübeck, Germany
5. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD USA
6. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD USA

Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disease caused by the loss of dopaminergic neurons; however, growing evidence indicates the widespread involvement of cortical regions underlying motor and non-motor symptoms. In this study, we evaluated multiparametric mapping (MPM) as a non-invasive imaging technique for the detection of microstructural brain alterations in PD. We assessed 31 patients with idiopathic PD (PwPD) and 68 healthy controls (HCs) utilizing MPM-derived longitudinal relaxation rate (R1), effective transverse relaxation rate (R2*), proton density, and magnetic transfer saturation (MTsat). We performed a whole-brain voxel-based quantification (VBQ) and multiple linear regression analysis to assess group differences and associations with the clinical phenotype. Lower MTsat within the left superior frontal gyrus (SFG) predicted motor symptom severity in PwPD, while higher R2* values in the right SFG were associated with higher levodopa-equivalent daily dose. Higher R2* values in the posterior cingulate gyrus and lower proton density in the left superior parietal lobule were associated with a stronger cognitive impairment in PwPD. Additionally, numerous clusters presented with group differences across multiple MPM modalities, including the supplementary motor area and cingulate cortex. Overall, we successfully replicated previously documented cortical microstructural changes in PwPD, presenting MPM as a sensitive tool for the detection of disease-specific alterations. This study further underscores the utility of MPM for monitoring disease progression through biologically informed measures, opening avenues for further research.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Code availability

The code used for the analyses in this study is available from the corresponding author upon reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data Availability Statement

The data supporting this study are available from the corresponding author upon reasonable request. The code used for the analyses in this study is available from the corresponding author upon reasonable request.

The code used for the analyses in this study is available from the corresponding author upon reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 3 keywords, 1 funder, 67 references.

Cite

This paper

Pokotylo, M. M., Göttlich, M., Schmidt, L., Weingarten, H. S., Dirksen, L., Albrecht, L., Griebner, N., Uter, J., Henkel, J., Brüggemann, N., & Prasuhn, J. (2026). In-vivo histology of Parkinson's disease using quantitative multiparametric mapping. NPJ Parkinson's disease, 12(1), 82. https://doi.org/10.1038/s41531-026-01329-4

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