OSCR

The pattern of fMRI activation with STN DBS reveals symptom-specific networks.

Overview

Authors: Brendan Santyr1, Aaron Loh1, Jürgen Germann1,2,3, Alexandre Boutet1,4, Afis Ajala5, Jianwei Qiu5, Ghadh Albuainain6, Mohamad Abbass7, Radhika Madhavan5, Gavin Elias1, Artur Vetkas1, Clement Chow1, Can Sarica1, Renato Munhoz2,8, George M. Ibrahim9, Suneil Kalia1,2,3, Alfonso Fasano2,3,8, Andres M. Lozano1,2,3
ORCID iDs: Jianwei Qiu, Can Sarica, Andres M. Lozano
  1. Division of Neurosurgery, Department of Surgery, University of Toronto,Toronto, ON Canada
  2. Krembil Brain Institute,Toronto, ON Canada
  3. Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON Canada
  4. Joint Department of Medical Imaging, University of Toronto,Toronto, ON Canada
  5. GE HealthCare Technology & Innovation Center, Niskayuna,New York, NY USA
  6. Department of Neurology, Imam Abdulrahman Bin Faisal University,Dammam, Saudi Arabia
  7. Department of Clinical Neurological Sciences, Western University, London,Toronto, ON Canada
  8. Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN,Toronto, ON Canada
  9. Division of Neurosurgery, Hospital for Sick Children,Toronto, ON Canada
Institutions: University of Toronto (Canada); Krembil Brain Institute; GE HealthCare Technology & Innovation Center, Niskayuna,New York, NY USA; Imam Abdulrahman Bin Faisal University (Saudi Arabia); Western University (Canada); Toronto Western Hospital (Canada); Hospital for Sick Children (Canada)
Journal: NPJ Parkinson's disease, volume 12, issue 1, article 165
Dates: received 21 December 2025; accepted 17 April 2026; published online 28 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41531-026-01368-x · PMID 42049768 · PMCID PMC13328640 · OpenAlex W7157019118
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: fMRI (modality), Parkinson's (population), clinical / translational (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, fMRI & imaging
Keywords: Neurology, Neuroscience
Topic: Neurological disorders and treatments (Neurology, Medicine), according to OpenAlex
Funding: Parkinson Canada; Michael J. Fox Foundation (MJFF-008877); National Institute of Neurological Disorders and Stroke of the National Institutes of Health (1R01NS133433-01); European Joint Programme Neurodegenerative Disease Research (JPND)
Citations: not cited yet (Europe PMC); 55 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

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  • it says that the code is available on request

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Tracing map

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Data

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Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41531-026-01368-x.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 18 authors, 2 keywords, 4 funders, 54 references.

Cite

This paper

Santyr, B., Loh, A., Germann, J., Boutet, A., Ajala, A., Qiu, J., Albuainain, G., Abbass, M., Madhavan, R., Elias, G., Vetkas, A., Chow, C., Sarica, C., Munhoz, R., Ibrahim, G. M., Kalia, S., Fasano, A., & Lozano, A. M. (2026). The pattern of fMRI activation with STN DBS reveals symptom-specific networks. NPJ Parkinson's disease, 12(1), 165. https://doi.org/10.1038/s41531-026-01368-x

BibTeX

@article{santyr2026pattern,
author = {Santyr, Brendan and Loh, Aaron and Germann, Jürgen and Boutet, Alexandre and Ajala, Afis and Qiu, Jianwei and Albuainain, Ghadh and Abbass, Mohamad and Madhavan, Radhika and Elias, Gavin and Vetkas, Artur and Chow, Clement and Sarica, Can and Munhoz, Renato and Ibrahim, George M. and Kalia, Suneil and Fasano, Alfonso and Lozano, Andres M.},
title = {{The pattern of fMRI activation with STN DBS reveals symptom-specific networks}},
journal = {NPJ Parkinson's disease},
year = {2026},
month = apr,
volume = {12},
number = {1},
pages = {165},
publisher = {Nature Publishing Group},
issn = {2373-8057},
doi = {10.1038/s41531-026-01368-x},
url = {https://doi.org/10.1038/s41531-026-01368-x},
pmid = {42049768},
pmcid = {PMC13328640}
}

RIS

TY - JOUR
AU - Santyr, Brendan
AU - Loh, Aaron
AU - Germann, Jürgen
AU - Boutet, Alexandre
AU - Ajala, Afis
AU - Qiu, Jianwei
AU - Albuainain, Ghadh
AU - Abbass, Mohamad
AU - Madhavan, Radhika
AU - Elias, Gavin
AU - Vetkas, Artur
AU - Chow, Clement
AU - Sarica, Can
AU - Munhoz, Renato
AU - Ibrahim, George M.
AU - Kalia, Suneil
AU - Fasano, Alfonso
AU - Lozano, Andres M.
TI - The pattern of fMRI activation with STN DBS reveals symptom-specific networks
T2 - NPJ Parkinson's disease
J2 - NPJ Parkinsons Dis
PY - 2026
DA - 2026/04/28
VL - 12
IS - 1
SP - 165
SN - 2373-8057
PB - Nature Publishing Group
DO - 10.1038/s41531-026-01368-x
UR - https://doi.org/10.1038/s41531-026-01368-x
LA - en
ER -

CSL-JSON

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