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Oligomeric Alpha-Synuclein from neural-derived extracellular vesicles as possible biomarkers of non-motor symptoms in Parkinson's disease.

Overview

Authors: Mario Meloni1, Cristina Agliardi2, Anna Salvatore3, Francesca Lea Saibene3, Massimo Marano4,5, Anna Castagna3, Pietro Arcuri3, Milena Zanzottera2, Franca Rosa Guerini2, Mario Clerici2,6
  1. Neurology Unit, Azienda Ospedaliero-Universitaria,Cagliari, Italy
  2. Laboratory of Molecular Medicine and Biotech (LAMMB), IRCCS Fondazione Don Carlo Gnocchi ETS,Milan, Italy
  3. Neurorehabilitation Unit, IRCCS Fondazione Don Carlo Gnocchi ETS,Milan, Italy
  4. Department of Medicine, Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, University Campus Bio-Medico of Rome,Rome, Italy
  5. Fondazione Policlinico Universitario Campus Bio - Medico,Rome, Italy
  6. Department of Pathophysiology and Transplantation, University of Milan,Milan, Italy
Institutions: Azienda Ospedaliero-Universitaria Cagliari (Italy); Don Carlo Gnocchi Foundation (Italy); Università Campus Bio-Medico (Italy); Campus Bio Medico University Hospital (Italy); University of Milan (Italy)
Journal: NPJ Parkinson's disease, volume 12, issue 1, article 203
Dates: received 8 February 2026; accepted 3 July 2026; published online 28 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41531-026-01474-w · PMID 42649220 · PMCID PMC13518858 · OpenAlex W7171505255
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: Parkinson's (population), clinical / translational (subfield)
Methods: Smoothing, state filtering, decompositions, Statistics, Connectivity
Keywords: Biomarkers, Diseases, Neurology, Neuroscience
Topic: Parkinson's Disease Mechanisms and Treatments (Neurology, Medicine), according to OpenAlex
Funding: Fondazione Alessandro and Vincenzo Negroni Prati Morosini and Fondazione Romeo and Enrica Invernizzi
Citations: not cited yet (Europe PMC); 40 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41531-026-01474-w.

Tracing map

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Data

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Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41531-026-01474-w.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 4 keywords, 1 funder, 39 references.

Cite

This paper

Meloni, M., Agliardi, C., Salvatore, A., Saibene, F. L., Marano, M., Castagna, A., Arcuri, P., Zanzottera, M., Guerini, F. R., & Clerici, M. (2026). Oligomeric Alpha-Synuclein from neural-derived extracellular vesicles as possible biomarkers of non-motor symptoms in Parkinson's disease. NPJ Parkinson's disease, 12(1), 203. https://doi.org/10.1038/s41531-026-01474-w

BibTeX

@article{meloni2026oligomeric,
author = {Meloni, Mario and Agliardi, Cristina and Salvatore, Anna and Saibene, Francesca Lea and Marano, Massimo and Castagna, Anna and Arcuri, Pietro and Zanzottera, Milena and Guerini, Franca Rosa and Clerici, Mario},
title = {{Oligomeric Alpha-Synuclein from neural-derived extracellular vesicles as possible biomarkers of non-motor symptoms in Parkinson's disease}},
journal = {NPJ Parkinson's disease},
year = {2026},
month = jul,
volume = {12},
number = {1},
pages = {203},
publisher = {Nature Publishing Group},
issn = {2373-8057},
doi = {10.1038/s41531-026-01474-w},
url = {https://doi.org/10.1038/s41531-026-01474-w},
pmid = {42649220},
pmcid = {PMC13518858}
}

RIS

TY - JOUR
AU - Meloni, Mario
AU - Agliardi, Cristina
AU - Salvatore, Anna
AU - Saibene, Francesca Lea
AU - Marano, Massimo
AU - Castagna, Anna
AU - Arcuri, Pietro
AU - Zanzottera, Milena
AU - Guerini, Franca Rosa
AU - Clerici, Mario
TI - Oligomeric Alpha-Synuclein from neural-derived extracellular vesicles as possible biomarkers of non-motor symptoms in Parkinson's disease
T2 - NPJ Parkinson's disease
J2 - NPJ Parkinsons Dis
PY - 2026
DA - 2026/07/28
VL - 12
IS - 1
SP - 203
SN - 2373-8057
PB - Nature Publishing Group
DO - 10.1038/s41531-026-01474-w
UR - https://doi.org/10.1038/s41531-026-01474-w
LA - en
ER -

CSL-JSON

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