OSCR

Regional reduction of high-energy phosphorus metabolites characterizes the cerebellar subtype of multiple system atrophy.

Overview

Authors: Jannik Prasuhn1,2,3,4,5, Christina Bodemann1,2,3, Britt Ebeling1,2,3, Katharina Reuther1,2,3, Sinja S. Großer1,2,3, Jan Uter1,3, Julia Henkel1,3, Henrike Hanssen1,2,3, Norbert Brüggemann1,2,3
  1. Section of Movement Disorders, Department of Neurology, University Medical Center Schleswig-Holstein,Lübeck, Germany
  2. Institute of Neurogenetics, University of Lübeck,Lübeck, Germany
  3. Center for Brain, Behavior, and Metabolism, University of Lübeck,Lübeck, Germany
  4. Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine,Baltimore, MD USA
  5. F.M. Kirby Research Center for Functional Brain Imaging, Hugo W. Moser Research Institute at Kennedy Krieger,Baltimore, MD USA
Institutions: University Hospital Schleswig-Holstein (Germany); University of Lübeck (Germany); Johns Hopkins University (United States); Kennedy Krieger Institute (United States)
Journal: NPJ Parkinson's disease, volume 12, issue 1, article 199
Dates: received 25 April 2026; accepted 13 August 2026; published online 20 August 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1038/s41531-026-01537-y · PMID 42624856 · PMCID PMC13493920 · OpenAlex W7203837535
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), Parkinson's (population), clinical / translational (subfield)
Methods: Connectivity, fMRI & imaging
Keywords: Diseases, Neurology, Neuroscience
Topic: Parkinson's Disease Mechanisms and Treatments (Neurology, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 32 references in the paper

Abstract

Multiple system atrophy (MSA) is a severe neurodegenerative disorder with various underlying pathophysiological features. Mitochondrial dysfunction has been implied as a viable treatment target in patients with MSA. Yet, there is a lack of in-vivo studies examining regional metabolic differences between the Parkinsonian (MSAp) and the cerebellar (MSAc) subtype of MSA. Twenty-four patients with MSA (12 patients with MSAp and 12 patients with MSAc), 24 patients with Parkinson’s disease (PD), and 24 age- and sex-matched healthy controls (HCs) underwent clinical evaluations and multimodal neuroimaging, including 31P-MRSI targeting the basal ganglia and the cerebellum. Ratios of high-energy phosphorus-containing metabolites (HEPs) were compared between groups. Only patients with MSAc showed decreased HEP levels in the cerebellum. Conversely, no differences in basal ganglia HEP levels appeared between both MSA subtypes, patients with PD, or HCs. Our findings provide preliminary in-vivo evidence for regionally detectable bioenergetic alterations in the cerebellum of patients with MSAc, while basal ganglia results, particularly in MSAp, require cautious interpretation because of the spatial-resolution limits of the present 31P-MRSI approach.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability

The code used in this study is available from the corresponding author upon reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Data availability

The datasets generated and/or analyzed during the current study are not publicly available due to data safety regulations but are available from the corresponding author on reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 3 keywords, 32 references.

Cite

This paper

Prasuhn, J., Bodemann, C., Ebeling, B., Reuther, K., Großer, S. S., Uter, J., Henkel, J., Hanssen, H., & Brüggemann, N. (2026). Regional reduction of high-energy phosphorus metabolites characterizes the cerebellar subtype of multiple system atrophy. NPJ Parkinson's disease, 12(1), 199. https://doi.org/10.1038/s41531-026-01537-y

BibTeX

@article{prasuhn2026regional,
author = {Prasuhn, Jannik and Bodemann, Christina and Ebeling, Britt and Reuther, Katharina and Großer, Sinja S. and Uter, Jan and Henkel, Julia and Hanssen, Henrike and Brüggemann, Norbert},
title = {{Regional reduction of high-energy phosphorus metabolites characterizes the cerebellar subtype of multiple system atrophy}},
journal = {NPJ Parkinson's disease},
year = {2026},
month = aug,
volume = {12},
number = {1},
pages = {199},
publisher = {Nature Publishing Group},
issn = {2373-8057},
doi = {10.1038/s41531-026-01537-y},
url = {https://doi.org/10.1038/s41531-026-01537-y},
pmid = {42624856},
pmcid = {PMC13493920}
}

RIS

TY - JOUR
AU - Prasuhn, Jannik
AU - Bodemann, Christina
AU - Ebeling, Britt
AU - Reuther, Katharina
AU - Großer, Sinja S.
AU - Uter, Jan
AU - Henkel, Julia
AU - Hanssen, Henrike
AU - Brüggemann, Norbert
TI - Regional reduction of high-energy phosphorus metabolites characterizes the cerebellar subtype of multiple system atrophy
T2 - NPJ Parkinson's disease
J2 - NPJ Parkinsons Dis
PY - 2026
DA - 2026/08/20
VL - 12
IS - 1
SP - 199
SN - 2373-8057
PB - Nature Publishing Group
DO - 10.1038/s41531-026-01537-y
UR - https://doi.org/10.1038/s41531-026-01537-y
LA - en
ER -

CSL-JSON

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