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Deconstruction of a spino-brain-spinal cord circuit that drives chronic pain.

Code ↔ Paper

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Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

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The authors' code

MATLAB · 28 lines · 572 B · no license

  1. function blocks=getBlocks(state,tag)
  2. sLen = length(state);
  3. d1 = state*0;
  4. idx = (state==tag);
  5. d1(2:end) = idx(2:end) - idx(1:end-1);
  6. idx1 = find(d1==1);
  7. idx2 = find(d1 == -1);
  8. idx0 = find(d1 ~= 0);
  10. blocks = [];
  11. if isempty(idx0) || isempty(idx1) || isempty(idx2)
  12. return;
  13. end
  15. if idx0(1) == idx2(1)
  16. idx1 = [1;idx1];
  17. end
  19. if idx0(end) == idx1(end)
  20. idx2 = [idx2;sLen];
  21. end
  23. elen = max(length(idx1), length(idx2));
  24. blocks = zeros(elen, 4);
  25. blocks(:,1) = (1:elen)';
  26. blocks(:,2) = idx1';
  27. blocks(:,3) = idx2';
  28. blocks(:,4) = blocks(:,3) - blocks(:,2);

getBlocks.m at commit 38d7cc3, no license · at the source

Overview

Authors: Qian Wang1, Joo Han Lee1, Gregory Nachtrab1, Yuan Yuan1, Lei Yuan1, Wei Qi1, Manuel A Mohr1, Jing Xiong2, Mark A Horowitz2, Xiaoke Chen1
ORCID iDs: Yuan Yuan, Manuel A Mohr, Xiaoke Chen
  1. Department of Biology, Stanford University, Stanford, CA USA
  2. Department of Electrical Engineering, Stanford University, Stanford, CA USA
Institutions: Stanford University (United States)
Journal: Nature, volume 654, issue 8117, pages 142-151
Dates: received 19 October 2024; accepted 18 February 2026; published online 1 April 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41586-026-10296-y · PMID 41922770 · PMCID PMC13078944 · OpenAlex W7147326831
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Categories: mouse (organism), pain (population), systems (subfield)
Methods: Statistics, Evoked potentials, Connectivity, Single-unit activity, calcium imaging, Physiology & signal measures
Keywords: Neural circuits, Chronic pain
MeSH: Brain*, Chronic Pain*, Neural Pathways*, Spinal Cord*, Animals, Disease Models, Animal, Female, Hyperalgesia, Inflammation, Male, Mice, Neuralgia, Neurons, Nociception, Receptors, Opioid, mu, Somatosensory Cortex, Thalamus (* major topic)
Topic: Pain Mechanisms and Treatments (Physiology, Medicine), according to OpenAlex
Funding: NINDS NIH HHS (R01 NS129834, RF1 NS126076); NIDA NIH HHS (R01 DA045664, R01 DA059602); NIMH NIH HHS (R01 MH135934, R01 MH116904); NHLBI NIH HHS (R01 HL150566)
Citations: cited by 5 papers (Europe PMC); 59 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repositories

Its files are read in the Code ↔ Paper reader above.

sites.google.com/view/brain-mapping

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers (HTTP 200)
  • 28 September 2026: the link answers (HTTP 200)
At the source: sites.google.com/view/brain-mapping/home/code

thepenglab/posTracker

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: files inventoried
Commit: 38d7cc35360115cd73e6e463e748fcbd5e1caf1b, 18 December 2023
Languages: MATLAB (7)
Size: 10 files, 7 scripts
Software Heritage: not archived
Found in: “Code availability”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: Image Processing Toolbox (1 file), Statistics and Machine Learning Toolbox (1 file)
Availability: 1 check, the latest on 28 September 2026: the link answers
  • 28 September 2026: the link answers
8 files
At the source: github.com/thepenglab/posTracker

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41586-026-10296-y.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 7 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41586-026-10296-y.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Nature Portfolio

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 2 keywords, 17 MeSH terms, 4 funders, 59 references.

Cite

This paper

Wang, Q., Lee, J. H., Nachtrab, G., Yuan, Y., Yuan, L., Qi, W., Mohr, M. A., Xiong, J., Horowitz, M. A., & Chen, X. (2026). Deconstruction of a spino-brain-spinal cord circuit that drives chronic pain. Nature, 654(8117), 142-151. https://doi.org/10.1038/s41586-026-10296-y

BibTeX

@article{wang2026deconstruction,
author = {Wang, Qian and Lee, Joo Han and Nachtrab, Gregory and Yuan, Yuan and Yuan, Lei and Qi, Wei and Mohr, Manuel A and Xiong, Jing and Horowitz, Mark A and Chen, Xiaoke},
title = {{Deconstruction of a spino-brain-spinal cord circuit that drives chronic pain}},
journal = {Nature},
year = {2026},
month = apr,
volume = {654},
number = {8117},
pages = {142--151},
publisher = {Nature Portfolio},
issn = {0028-0836},
doi = {10.1038/s41586-026-10296-y},
url = {https://doi.org/10.1038/s41586-026-10296-y},
pmid = {41922770},
pmcid = {PMC13078944}
}

RIS

TY - JOUR
AU - Wang, Qian
AU - Lee, Joo Han
AU - Nachtrab, Gregory
AU - Yuan, Yuan
AU - Yuan, Lei
AU - Qi, Wei
AU - Mohr, Manuel A
AU - Xiong, Jing
AU - Horowitz, Mark A
AU - Chen, Xiaoke
TI - Deconstruction of a spino-brain-spinal cord circuit that drives chronic pain
T2 - Nature
J2 - Nature
PY - 2026
DA - 2026/04/01
VL - 654
IS - 8117
SP - 142
EP - 151
SN - 0028-0836
PB - Nature Portfolio
DO - 10.1038/s41586-026-10296-y
UR - https://doi.org/10.1038/s41586-026-10296-y
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41586-026-10296-y",
"type": "article-journal",
"title": "Deconstruction of a spino-brain-spinal cord circuit that drives chronic pain",
"container-title": "Nature",
"author": [
{
"family": "Wang",
"given": "Qian"
},
{
"family": "Lee",
"given": "Joo Han"
},
{
"family": "Nachtrab",
"given": "Gregory"
},
{
"family": "Yuan",
"given": "Yuan"
},
{
"family": "Yuan",
"given": "Lei"
},
{
"family": "Qi",
"given": "Wei"
},
{
"family": "Mohr",
"given": "Manuel A"
},
{
"family": "Xiong",
"given": "Jing"
},
{
"family": "Horowitz",
"given": "Mark A"
},
{
"family": "Chen",
"given": "Xiaoke"
}
],
"container-title-short": "Nature",
"volume": "654",
"issue": "8117",
"page": "142-151",
"DOI": "10.1038/s41586-026-10296-y",
"PMID": "41922770",
"PMCID": "PMC13078944",
"ISSN": "0028-0836",
"publisher": "Nature Portfolio",
"URL": "https://doi.org/10.1038/s41586-026-10296-y",
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
1
]
]
}
}

The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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