OSCR

The neural mechanisms supporting the rise and fall of maternal aggression.

Overview

Authors: Takashi Yamaguchi1, Rongzhen Yan1, Mashrur Khan1, Sota Kuno2, Kanishk Tewatia1, Takuya Osakada1, Srinivas Parthasarathy3,4,5, Michael E Pacold2, Nirao M Shah3,4,6, Dayu Lin1,7,8
ORCID iDs: Takashi Yamaguchi, Rongzhen Yan, Sota Kuno, Michael E Pacold, Nirao M Shah, Dayu Lin
  1. Institute of Translational Neuroscience, New York University Langone Medical Center, New York, NY USA
  2. Department of Radiation Oncology, New York University Langone Health, New York, NY USA
  3. Departments of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA USA
  4. Department of Neurobiology, Stanford University, Stanford, CA USA
  5. Accent Therapeutics, Lexington, MA USA
  6. Department of Obstetrics and Gynecology, Stanford University, Stanford, CA USA
  7. Department of Psychiatry, New York University Langone Medical Center, New York, NY USA
  8. Department of Neuroscience, New York University Langone Medical Center, New York, NY USA
Institutions: NYU Langone Health (United States); New York University (United States); Accent Therapeutics (United States) (United States); Stanford Medicine (United States); Stanford University (United States)
Journal: Nature, volume 654, issue 8120, pages 1012-1022
Dates: received 4 January 2025; accepted 3 March 2026; published online 15 April 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41586-026-10354-5 · PMID 41986710 · PMCID PMC13135462 · OpenAlex W4413071873
Open access: hybrid, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.07.15.665001
Status: code verified
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics, Evoked potentials, Single-unit activity, calcium imaging
Keywords: Social behaviour, Neural circuits, Synaptic plasticity
MeSH: Aggression*, Maternal Behavior*, Neurons*, Amygdala, Animals, Estrogen Receptor alpha, Female, Lactation, Male, Mice, Neural Pathways, Neuronal Plasticity, Optogenetics, Oxytocin, Receptors, Neuropeptide Y, Receptors, Oxytocin, Synapses, Ventromedial Hypothalamic Nucleus (* major topic)
Topic: Neuroendocrine regulation and behavior (Social Psychology, Psychology), according to OpenAlex
Funding: NICHD NIH HHS (R01 HD108363, R01 HD116127, R01 HD109519); NINDS NIH HHS (R01 NS049488, U19 NS107616); NIGMS NIH HHS (R35 GM147119); NIMH NIH HHS (R01 MH101377, R01 MH124927)
Citations: cited by 7 papers (Europe PMC); 51 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

pdollar.github.io/toolbox

License: none: the authors keep all their rights
State: the link answers, verified on 29 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: the text, “Behavioural analysis”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 29 September 2026: the link answers (HTTP 200)
  • 29 September 2026: the link answers (HTTP 200)
At the source: pdollar.github.io/toolbox/

Zenodo 18394527

License: CC-BY-4.0
State: the link answers, verified on 29 September 2026
Evidence: files inventoried
Size: 16 files
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 29 September 2026: the link answers (HTTP 200)
  • 29 September 2026: the link answers (HTTP 200)
At the source:

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to the authors' code: Zenodo 18394527

Read it in the paper: doi.org/10.1038/s41586-026-10354-5.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41586-026-10354-5.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 3 keywords, 18 MeSH terms, 4 funders, 48 references.

Cite

This paper

Yamaguchi, T., Yan, R., Khan, M., Kuno, S., Tewatia, K., Osakada, T., Parthasarathy, S., Pacold, M. E., Shah, N. M., & Lin, D. (2026). The neural mechanisms supporting the rise and fall of maternal aggression. Nature, 654(8120), 1012-1022. https://doi.org/10.1038/s41586-026-10354-5

BibTeX

@article{yamaguchi2026neural,
author = {Yamaguchi, Takashi and Yan, Rongzhen and Khan, Mashrur and Kuno, Sota and Tewatia, Kanishk and Osakada, Takuya and Parthasarathy, Srinivas and Pacold, Michael E and Shah, Nirao M and Lin, Dayu},
title = {{The neural mechanisms supporting the rise and fall of maternal aggression}},
journal = {Nature},
year = {2026},
month = apr,
volume = {654},
number = {8120},
pages = {1012--1022},
publisher = {Nature Portfolio},
issn = {0028-0836},
doi = {10.1038/s41586-026-10354-5},
url = {https://doi.org/10.1038/s41586-026-10354-5},
pmid = {41986710},
pmcid = {PMC13135462}
}

RIS

TY - JOUR
AU - Yamaguchi, Takashi
AU - Yan, Rongzhen
AU - Khan, Mashrur
AU - Kuno, Sota
AU - Tewatia, Kanishk
AU - Osakada, Takuya
AU - Parthasarathy, Srinivas
AU - Pacold, Michael E
AU - Shah, Nirao M
AU - Lin, Dayu
TI - The neural mechanisms supporting the rise and fall of maternal aggression
T2 - Nature
J2 - Nature
PY - 2026
DA - 2026/04/15
VL - 654
IS - 8120
SP - 1012
EP - 1022
SN - 0028-0836
PB - Nature Portfolio
DO - 10.1038/s41586-026-10354-5
UR - https://doi.org/10.1038/s41586-026-10354-5
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41586-026-10354-5",
"type": "article-journal",
"title": "The neural mechanisms supporting the rise and fall of maternal aggression",
"container-title": "Nature",
"author": [
{
"family": "Yamaguchi",
"given": "Takashi"
},
{
"family": "Yan",
"given": "Rongzhen"
},
{
"family": "Khan",
"given": "Mashrur"
},
{
"family": "Kuno",
"given": "Sota"
},
{
"family": "Tewatia",
"given": "Kanishk"
},
{
"family": "Osakada",
"given": "Takuya"
},
{
"family": "Parthasarathy",
"given": "Srinivas"
},
{
"family": "Pacold",
"given": "Michael E"
},
{
"family": "Shah",
"given": "Nirao M"
},
{
"family": "Lin",
"given": "Dayu"
}
],
"container-title-short": "Nature",
"volume": "654",
"issue": "8120",
"page": "1012-1022",
"DOI": "10.1038/s41586-026-10354-5",
"PMID": "41986710",
"PMCID": "PMC13135462",
"ISSN": "0028-0836",
"publisher": "Nature Portfolio",
"URL": "https://doi.org/10.1038/s41586-026-10354-5",
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
15
]
]
}
}

The tracing map gets a citation of its own once an author has validated it and it has a DOI.

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1016/j.isci.2026.117412 [code]
Transcriptomic landscape of microglia in mouse models of social dysfunction and oxytocin-mediated recovery.
Journal: iScience
In common: mouse, cellular / molecular, 3 references
[2] doi:10.7554/elife.103224 [code]
Brainstem neurons coordinate the bladder and urethral sphincter for urination.
Journal: eLife
In common: mouse, cellular / molecular, 3 references
[3] doi:10.1038/s41598-026-50956-7
Genome editing-based refinement of GPCR visualization in mice using the oxytocin receptor as a model.
Journal: Scientific reports
In common: mouse, cellular / molecular, 3 references
[4] doi:10.1073/pnas.2605466123 [code]
Parabrachial <i>Ntsr1</i> neurons modulate food intake and anxiety through a projection to the ventromedial hypothalamus.
Journal: Proceedings of the National Academy of Sciences of the United States of America
In common: mouse, cellular / molecular, 2 references
[5] doi:10.7554/elife.106347 [code]
Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence.
Journal: eLife
In common: mouse, 2 references
[6] doi:10.1073/pnas.2603966123 [code]
Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.
Journal: Proceedings of the National Academy of Sciences of the United States of America
In common: mouse, 2 references
[7] doi:10.1038/s41467-026-75723-0 [code]
Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G.
Journal: Nature communications
In common: mouse, cellular / molecular, 2 references
[8] doi:10.7554/elife.102309 [code]
Dimorphic neural network architecture prioritizes sexual-related behaviors in male <i>Caenorhabditis elegans</i>.
Journal: eLife
In common: 2 references
[9] doi:10.1016/j.isci.2026.116321
Chemogenetic activation of the amygdala core nucleus increases aggression in chickens.
Journal: iScience
In common: 2 references
[10] doi:10.1038/s41598-026-35639-7 [code]
Neural correlates of adversity-overcoming pup rescue behavior in female mice.
Journal: Scientific reports
In common: mouse, cellular / molecular, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.