OSCR

Confined migration induces non-lethal DNA damage in developing neurons.

Overview

Authors: Zhejing Zhang1,2, Andres Canela2,3, Junko Kurisu1, Peilin Zou1,2, Takumi Kawaue1,4, Naotaka Nakazawa1,5, Noriko Takeda1,2, Mai Saeki6, Masaki Utsunomiya1,2, Merve Bilgic6, Fumiyoshi Ishidate1, Gianluca Grenci7, Takahiro Furuta8, Yusuke Kishi6,9,10, Hiroyuki Sasanuma11,12, Mineko Kengaku1,2
ORCID iDs: Naotaka Nakazawa, Gianluca Grenci, Takahiro Furuta, Yusuke Kishi, Mineko Kengaku
  1. Institute for Integrated Cell-Material Science (WPI-iCeMS), Kyoto University,Kyoto, Japan
  2. Graduate School of Biostudies, Kyoto University,Kyoto, Japan
  3. Radiation Biology Center, Kyoto University,Kyoto, Japan
  4. Present Address: Department of Anatomy and Cell Biology, Faculty of Medicine, Nagoya University,Nagoya, Japan
  5. Present Address: Faculty of Science and Engineering, Kindai University,Osaka, Japan
  6. Institute for Quantitative Biosciences, The University of Tokyo,Tokyo, Japan
  7. Mechanobiology Institute, National University of Singapore,Singapore, Singapore
  8. Department of Systematic Anatomy and Neurobiology, Graduate School of Dentistry, The University of Osaka,Osaka, Japan
  9. Graduate School of Pharmaceutical Sciences, The University of Tokyo,Tokyo, Japan
  10. Division of Aging Biology, Research Institute for Science and Technology, Tokyo University of Science,Chiba, Japan
  11. Department of Radiation Genetics, Graduate School of Medicine, Kyoto University,Kyoto, Japan
  12. Department of Genome Dynamics, Tokyo Metropolitan Institute of Medical Science,Tokyo, Japan
Institutions: Kyoto University (Japan); Nagoya University (Japan); Kindai University (Japan); The University of Tokyo (Japan); National University of Singapore (Singapore); The University of Osaka (Japan); Tokyo University of Science (Japan); Tokyo Metropolitan Institute of Medical Science (Japan)
Journal: Nature, volume 654, issue 8120, pages 1098-1107
Dates: received 6 June 2025; accepted 12 May 2026; published online 17 June 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41586-026-10648-8 · PMID 42310452 · PMCID PMC13293896 · OpenAlex W7165032631
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Connectivity, Evoked potentials, Statistics
Keywords: Cell migration, Double-strand DNA breaks, Neuronal development
MeSH: Cell Movement*, DNA Breaks, Double-Stranded*, DNA Damage*, Neurons*, Animals, Cerebellum, DNA Ligase ATP, DNA Repair, DNA Topoisomerases, Type II, Female, Male, Mice, Nuclear Envelope, Transcription, Genetic (* major topic)
Topic: DNA Repair Mechanisms (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Citations: cited by 1 paper (Europe PMC); 77 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41586-026-10648-8.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Nature Portfolio

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 3 keywords, 14 MeSH terms, 77 references.

Cite

This paper

Zhang, Z., Canela, A., Kurisu, J., Zou, P., Kawaue, T., Nakazawa, N., Takeda, N., Saeki, M., Utsunomiya, M., Bilgic, M., Ishidate, F., Grenci, G., Furuta, T., Kishi, Y., Sasanuma, H., & Kengaku, M. (2026). Confined migration induces non-lethal DNA damage in developing neurons. Nature, 654(8120), 1098-1107. https://doi.org/10.1038/s41586-026-10648-8

BibTeX

@article{zhang2026confined,
author = {Zhang, Zhejing and Canela, Andres and Kurisu, Junko and Zou, Peilin and Kawaue, Takumi and Nakazawa, Naotaka and Takeda, Noriko and Saeki, Mai and Utsunomiya, Masaki and Bilgic, Merve and Ishidate, Fumiyoshi and Grenci, Gianluca and Furuta, Takahiro and Kishi, Yusuke and Sasanuma, Hiroyuki and Kengaku, Mineko},
title = {{Confined migration induces non-lethal DNA damage in developing neurons}},
journal = {Nature},
year = {2026},
month = jun,
volume = {654},
number = {8120},
pages = {1098--1107},
publisher = {Nature Portfolio},
issn = {0028-0836},
doi = {10.1038/s41586-026-10648-8},
url = {https://doi.org/10.1038/s41586-026-10648-8},
pmid = {42310452},
pmcid = {PMC13293896}
}

RIS

TY - JOUR
AU - Zhang, Zhejing
AU - Canela, Andres
AU - Kurisu, Junko
AU - Zou, Peilin
AU - Kawaue, Takumi
AU - Nakazawa, Naotaka
AU - Takeda, Noriko
AU - Saeki, Mai
AU - Utsunomiya, Masaki
AU - Bilgic, Merve
AU - Ishidate, Fumiyoshi
AU - Grenci, Gianluca
AU - Furuta, Takahiro
AU - Kishi, Yusuke
AU - Sasanuma, Hiroyuki
AU - Kengaku, Mineko
TI - Confined migration induces non-lethal DNA damage in developing neurons
T2 - Nature
J2 - Nature
PY - 2026
DA - 2026/06/17
VL - 654
IS - 8120
SP - 1098
EP - 1107
SN - 0028-0836
PB - Nature Portfolio
DO - 10.1038/s41586-026-10648-8
UR - https://doi.org/10.1038/s41586-026-10648-8
LA - en
ER -

CSL-JSON

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