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Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.

Overview

Authors: Satoka H. Fujimoto1,2,3, Atsushi Fujimoto1,2,3, Catherine Elorette1,2, Adela Seltzer1,2, Emma Andraka1,2, Keondre Herbert1,2, Gaurav Verma4,5, William G. M. Janssen1, Lazar Fleysher5, Davide Folloni1,2, Ki Sueng Choi4,5, Brian E. Russ1,6,7, Helen S. Mayberg1,4, Peter H. Rudebeck1,2
ORCID iDs: Satoka H. Fujimoto, Atsushi Fujimoto, Catherine Elorette, Keondre Herbert, Ki Sueng Choi, Brian E. Russ, Helen S. Mayberg, Peter H. Rudebeck
  1. Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai,New York, NY USA
  2. Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai,New York, NY USA
  3. Present Address: Department of Neuroscience and Center for Magnetic Resonance Research, University of Minnesota,Minneapolis, MN USA
  4. Nash Family Center for Advanced Circuit Therapeutics, Mount Sinai West Hospital,New York, NY USA
  5. BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai,New York, NY USA
  6. Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute,Orangeburg, NY USA
  7. Department of Psychiatry, New York University at Langone,New York, NY USA
Institutions: Icahn School of Medicine at Mount Sinai (United States); University of Minnesota (United States); Nash Family Center for Advanced Circuit Therapeutics, Mount Sinai West Hospital,New York, NY USA; Nathan Kline Institute for Psychiatric Research (United States); New York University (United States)
Journal: Nature neuroscience, volume 29, issue 7, pages 1722-1734
Dates: received 22 July 2024; accepted 14 April 2026; published online 1 June 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41593-026-02301-4 · PMID 42225897 · PMCID PMC13337501 · OpenAlex W4399708873
Open access: hybrid, a free copy (OpenAlex)
Preprint: doi:10.1101/2024.06.13.598710
Status: data only
Categories: non-human primate (organism), depression (population), systems (subfield)
Methods: Statistics, Preprocessing, Connectivity, fMRI & imaging
Keywords: Depression, Neural circuits, Myelin biology and repair
MeSH: Brain*, Deep Brain Stimulation*, Gyrus Cinguli*, Nerve Net*, White Matter*, Animals, Macaca mulatta, Male, Neural Pathways (* major topic)
Topic: Neurological disorders and treatments (Neurology, Medicine), according to OpenAlex
Funding: Hope for Depression Research Foundation The National Institute of Mental Health (NIMH) (1R01MH132789-01A1) The BRAIN initiative (RF1MH117040) NIMH (R01MH132064); BRAIN initiative (RF1MH117040). NIMH (R01MH132064). Overseas Research Fellowship from Takeda Science Foundation and a Brain & Behavior Research Foundation Young Investigator grant (#28979); Hope for Depression Research Foundation The National Institute of Mental Health (NIMH) (1R01MH132789-01A1); BRAIN initiative (RF1MH117040). NIMH (R01MH132064); BRAIN initiative (RF1MH117040) NIMH (R01MH132064) NIMH (R01MH111439) NINDS (R01NS109498)
Citations: cited by 6 papers (Europe PMC); 81 references in the paper
Research resources: RRID:AB_2633276, RRID:AB_443473

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

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Read it in the paper: doi.org/10.1038/s41593-026-02301-4.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41593-026-02301-4.

Versions

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Version 2, 28 September 2026

  • Publisher: n/a → Nature Portfolio

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 3 keywords, 9 MeSH terms, 5 funders, 79 references, 2 RRIDs.

Cite

This paper

Fujimoto, S. H., Fujimoto, A., Elorette, C., Seltzer, A., Andraka, E., Herbert, K., Verma, G., Janssen, W. G. M., Fleysher, L., Folloni, D., Choi, K. S., Russ, B. E., Mayberg, H. S., & Rudebeck, P. H. (2026). Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks. Nature neuroscience, 29(7), 1722-1734. https://doi.org/10.1038/s41593-026-02301-4

BibTeX

@article{fujimoto2026deep,
author = {Fujimoto, Satoka H. and Fujimoto, Atsushi and Elorette, Catherine and Seltzer, Adela and Andraka, Emma and Herbert, Keondre and Verma, Gaurav and Janssen, William G. M. and Fleysher, Lazar and Folloni, Davide and Choi, Ki Sueng and Russ, Brian E. and Mayberg, Helen S. and Rudebeck, Peter H.},
title = {{Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks}},
journal = {Nature neuroscience},
year = {2026},
month = jun,
volume = {29},
number = {7},
pages = {1722--1734},
publisher = {Nature Portfolio},
issn = {1097-6256},
doi = {10.1038/s41593-026-02301-4},
url = {https://doi.org/10.1038/s41593-026-02301-4},
pmid = {42225897},
pmcid = {PMC13337501}
}

RIS

TY - JOUR
AU - Fujimoto, Satoka H.
AU - Fujimoto, Atsushi
AU - Elorette, Catherine
AU - Seltzer, Adela
AU - Andraka, Emma
AU - Herbert, Keondre
AU - Verma, Gaurav
AU - Janssen, William G. M.
AU - Fleysher, Lazar
AU - Folloni, Davide
AU - Choi, Ki Sueng
AU - Russ, Brian E.
AU - Mayberg, Helen S.
AU - Rudebeck, Peter H.
TI - Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks
T2 - Nature neuroscience
J2 - Nat Neurosci
PY - 2026
DA - 2026/06/01
VL - 29
IS - 7
SP - 1722
EP - 1734
SN - 1097-6256
PB - Nature Portfolio
DO - 10.1038/s41593-026-02301-4
UR - https://doi.org/10.1038/s41593-026-02301-4
LA - en
ER -

CSL-JSON

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