HORDB 2.0: a comprehensive dataset of peptide hormones.

Overview

1. China Pharmaceutical University, Nanjing, China

Abstract

Peptide hormones are key signaling molecules secreted by endocrine cells that regulate vital physiological processes such as metabolism, growth, development, and reproduction. Advances in protein detection and computational approaches have led to the continuous identification of novel peptide hormones, highlighting their potential in basic research, clinical applications, and drug development. To support systematic studies in this field, we present HORDB 2.0, an open-access, manually curated dataset of peptide hormones. This dataset comprises 7,390 entries, including 7,307 peptide hormones and 83 peptide hormone drugs, corresponding to 372 marketed formulations. The dataset includes annotations on sequence, activity, structure, physicochemical properties, patents, clinical data, and literature references, where available. Additional parameters, including IC₅₀, EC₅₀, ED₅₀, and blood–brain barrier permeability, are also provided to facilitate peptide modification and drug design. HORDB 2.0 represents an expanded and enriched resource for peptide hormone research and therapeutic development, and may support downstream applications in endocrinology, pharmacology, and peptide-based drug discovery.

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Data

Datasets cited

• figshare:27233508, at figshare; found in the references
• zenodo:18530505, at Zenodo; found in “Data availability”

Data Availability Statement

The HORDB 2.0 dataset generated and described in this study—including all annotated peptide hormone entries, physicochemical properties, drug information, associated sequences, and structural files—has been deposited as a static, versioned archive in the Zenodo repository under the accession code 10.5281/zenodo.18530505. This archive contains the complete dataset in machine-readable formats (.xlsx, .fasta, .pdb, .zip) as detailed in the Data Records section. All data are freely available for download and reuse under the terms specified in the repository.

No custom code is associated with this Data Descriptor.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 2 MeSH terms, 2 funders, 28 references.

Cite

This paper

Hu, C., Ran, Y., Lao, X., & Zheng, H. (2026). HORDB 2.0: a comprehensive dataset of peptide hormones. Scientific data, 13(1), 1225. https://doi.org/10.1038/s41597-026-07514-7

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