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Preliminary efficacy of cognitive multisensory rehabilitation for neuropathic pain in chronic spinal cord injury: a phase I randomized controlled trial.

Overview

Authors: Ann Van de Winckel1, Sydney T. Carpentier2, Wei Deng2, Sara Bottale3, Lin Zhang4, Timothy J. Hendrickson5, Clas Linnman6, Kelvin O. Lim7, Bryon A. Mueller7, Rob Wudlick8, Ricardo Battaglino6, Leslie R. Morse6
  1. Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, Medical School, University of Minnesota,420 Delaware St SE (MMC388), Minneapolis, MN 55455 USA
  2. Rehabilitation Science Graduate Program, Department of Family Medicine and Community Health, Medical School, University of Minnesota,420 Delaware St SE (MMC388), Minneapolis, MN 55455 USA
  3. Centro Studi di Riabilitazione Neurocognitiva - Villa Miari (Study Center for Cognitive Multisensory Rehabilitation), Via Lesina di Sopra, 111, Santorso, 36014 VI Italy
  4. Division of Biostatistics, School of Public Health, University of Minnesota,2221 University Ave SE, Suite 200, Minneapolis, MN 55414 USA
  5. Masonic Institute for the Developing Brain, Minnesota Supercomputing Institute, University of Minnesota,2025 East River Parkway, Minneapolis, MN 55414 USA
  6. Department of Physical Medicine and Rehabilitation, Miller School of Medicine, University of Miami,1611 NW 12th Ave, Miami, FL 33136 USA
  7. Department of Psychiatry and Behavioral Sciences, Medical School, University of Minnesota,606 24th Ave S, Minneapolis, MN 55454 USA
  8. Department of Rehabilitation Medicine, Medical School, University of Minnesota,500 Boynton Health Service Bridge, 410 Church St. SE, Minneapolis, MN 55455 USA
Institutions: University of Minnesota (United States); University of Miami (United States)
Journal: Scientific reports, volume 16, issue 1, article 14330
Dates: received 26 May 2025; accepted 16 March 2026; published online 20 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-44859-w · PMID 41862607 · PMCID PMC13144352 · OpenAlex W7138855120
Open access: gold, a free copy (OpenAlex)
Categories: fMRI (modality), human (organism), other condition (population), pain (population)
Methods: Statistics, Connectivity, fMRI & imaging
Keywords: Spinal cord injury, Neuropathic pain, Cognitive multisensory rehabilitation, Sensory function, Motor function, Functional magnetic resonance imaging, Spinal cord diseases
MeSH: Neuralgia*, Spinal Cord Injuries*, Adult, Cognitive Training, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pain Measurement, Treatment Outcome (* major topic)
Topic: Pain Management and Treatment (Anesthesiology and Pain Medicine, Medicine), according to OpenAlex
Funding: Academic Investment Research Program (AIRP) University of Minnesota School of Medicine (AIRP2-IND-30); National Center for Advancing Translational Sciences of the National Institutes of Health (UL1TR002494); Biotechnology Research Center (P41EB015894); National Institute of Neurological Disorders & Stroke Institutional Center Core Grants to Support Neuroscience Research (P30 NS076408); High-Performance Connectome Upgrade for Human 3T MRI scanner (1S10OD017974)
Citations: cited by 2 papers (Europe PMC); 56 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41598-026-44859-w.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 7 keywords, 11 MeSH terms, 5 funders, 53 references.

Cite

This paper

Van de Winckel, A., Carpentier, S. T., Deng, W., Bottale, S., Zhang, L., Hendrickson, T. J., Linnman, C., Lim, K. O., Mueller, B. A., Wudlick, R., Battaglino, R., & Morse, L. R. (2026). Preliminary efficacy of cognitive multisensory rehabilitation for neuropathic pain in chronic spinal cord injury: a phase I randomized controlled trial. Scientific reports, 16(1), 14330. https://doi.org/10.1038/s41598-026-44859-w

BibTeX

@article{vandewinckel2026preliminary,
author = {Van de Winckel, Ann and Carpentier, Sydney T. and Deng, Wei and Bottale, Sara and Zhang, Lin and Hendrickson, Timothy J. and Linnman, Clas and Lim, Kelvin O. and Mueller, Bryon A. and Wudlick, Rob and Battaglino, Ricardo and Morse, Leslie R.},
title = {{Preliminary efficacy of cognitive multisensory rehabilitation for neuropathic pain in chronic spinal cord injury: a phase I randomized controlled trial}},
journal = {Scientific reports},
year = {2026},
month = mar,
volume = {16},
number = {1},
pages = {14330},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-44859-w},
url = {https://doi.org/10.1038/s41598-026-44859-w},
pmid = {41862607},
pmcid = {PMC13144352}
}

RIS

TY - JOUR
AU - Van de Winckel, Ann
AU - Carpentier, Sydney T.
AU - Deng, Wei
AU - Bottale, Sara
AU - Zhang, Lin
AU - Hendrickson, Timothy J.
AU - Linnman, Clas
AU - Lim, Kelvin O.
AU - Mueller, Bryon A.
AU - Wudlick, Rob
AU - Battaglino, Ricardo
AU - Morse, Leslie R.
TI - Preliminary efficacy of cognitive multisensory rehabilitation for neuropathic pain in chronic spinal cord injury: a phase I randomized controlled trial
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/03/20
VL - 16
IS - 1
SP - 14330
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-44859-w
UR - https://doi.org/10.1038/s41598-026-44859-w
LA - en
ER -

CSL-JSON

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