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Biphasic modulation of large-fiber excitability accompanied by dynamic nerve-intrinsic immune activation following CFA-induced peripheral inflammation in mice.

Overview

Authors: Shani Berkowitz1,2, Valery Golderman1,2, Zehavit Goldberg1,2, Anastasia Yerushkin1,2, Omer Goldberg2, Joab Chapman1,2,3, Amir Dori1,2,4,5, Nicola Maggio1,2,5,6, Tamar Ziv7, Jérôme Joël Devaux8, Efrat Shavit-Stein1,2,9
ORCID iDs: Shani Berkowitz, Jérôme Joël Devaux, Efrat Shavit-Stein
  1. Department of Neurology and Neurosurgery, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, 6997801 Israel
  2. Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan, 52626202 Israel
  3. Robert and Martha Harden Chair in Mental and Neurological Diseases, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, 6997801 Israel
  4. The Neuromuscular Unit, The Chaim Sheba Medical Center, Ramat Gan, 52626202 Israel
  5. Talpiot Medical Leadership Program, The Chaim Sheba Medical Center, Ramat Gan, 52626202 Israel
  6. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 6997801 Israel
  7. Smoler Proteomics Center, Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel
  8. Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France
  9. The TELEM Rubin Excellence in Biomedical Research Program, The Chaim Sheba Medical Center, Ramat Gan, Israel
Institutions: Tel Aviv University (Israel); Sheba Medical Center (Israel); Technion – Israel Institute of Technology (Israel); Centre National de la Recherche Scientifique (France); Inserm (France); Université de Montpellier (France); Institut de Génomique Fonctionnelle (France)
Journal: Scientific reports, volume 16, issue 1, article 18286
Dates: received 4 February 2026; accepted 7 April 2026; published online 17 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-48278-9 · PMID 41998154 · PMCID PMC13261134 · OpenAlex W7154751344
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), pain (population), cellular / molecular (subfield)
Methods: Preprocessing, Statistics, Evoked potentials
Keywords: Neuroinflammation, Large fiber excitability, Complement system, Coagulation system, Schwann cells, Nociception, Neurology, Neuroscience
MeSH: Freund's Adjuvant*, Inflammation*, Nerve Fibers, Myelinated*, Sciatic Nerve*, Animals, Cytokines, Disease Models, Animal, Male, Mice, Mice, Inbred C57BL, Proteomics, Thrombin (* major topic)
Topic: Peripheral Neuropathies and Disorders (Neurology, Medicine), according to OpenAlex
Funding: the Claire & Amedee Martier Institute for the Study of the Blindness & Visual Disorders; Israeli Science Foundation (ISF 858-23); Nehemia Rubin Excellence in Biomedical Research – The TELEM Program
Citations: not cited yet (Europe PMC); 59 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41598-026-48278-9.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 8 keywords, 12 MeSH terms, 3 funders, 58 references.

Cite

This paper

Berkowitz, S., Golderman, V., Goldberg, Z., Yerushkin, A., Goldberg, O., Chapman, J., Dori, A., Maggio, N., Ziv, T., Devaux, J. J., & Shavit-Stein, E. (2026). Biphasic modulation of large-fiber excitability accompanied by dynamic nerve-intrinsic immune activation following CFA-induced peripheral inflammation in mice. Scientific reports, 16(1), 18286. https://doi.org/10.1038/s41598-026-48278-9

BibTeX

@article{berkowitz2026biphasic,
author = {Berkowitz, Shani and Golderman, Valery and Goldberg, Zehavit and Yerushkin, Anastasia and Goldberg, Omer and Chapman, Joab and Dori, Amir and Maggio, Nicola and Ziv, Tamar and Devaux, Jérôme Joël and Shavit-Stein, Efrat},
title = {{Biphasic modulation of large-fiber excitability accompanied by dynamic nerve-intrinsic immune activation following CFA-induced peripheral inflammation in mice}},
journal = {Scientific reports},
year = {2026},
month = apr,
volume = {16},
number = {1},
pages = {18286},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-48278-9},
url = {https://doi.org/10.1038/s41598-026-48278-9},
pmid = {41998154},
pmcid = {PMC13261134}
}

RIS

TY - JOUR
AU - Berkowitz, Shani
AU - Golderman, Valery
AU - Goldberg, Zehavit
AU - Yerushkin, Anastasia
AU - Goldberg, Omer
AU - Chapman, Joab
AU - Dori, Amir
AU - Maggio, Nicola
AU - Ziv, Tamar
AU - Devaux, Jérôme Joël
AU - Shavit-Stein, Efrat
TI - Biphasic modulation of large-fiber excitability accompanied by dynamic nerve-intrinsic immune activation following CFA-induced peripheral inflammation in mice
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/04/17
VL - 16
IS - 1
SP - 18286
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-48278-9
UR - https://doi.org/10.1038/s41598-026-48278-9
LA - en
ER -

CSL-JSON

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