OSCR

Cardiac systole is associated with enhanced go responding in an orthogonalized go/nogo task.

Overview

Authors: Filippo Queirazza1,2, Joana Carvalheiro2, Marios G. Philiastides2
ORCID iDs: Joana Carvalheiro
  1. School of Health and Wellbeing, University of Glasgow,Glasgow, G12 0XH UK
  2. School of Psychology and Neuroscience, University of Glasgow,Glasgow, G12 8QB UK
Institutions: University of Glasgow (United Kingdom)
Journal: Scientific reports, volume 16, issue 1, article 23408
Dates: received 11 November 2025; accepted 8 May 2026; published online 21 May 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1038/s41598-026-52930-9 · PMID 42168386 · PMCID PMC13408127 · OpenAlex W7162011476
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: fMRI (modality), human (organism), cognitive (subfield)
Methods: Connectivity, Statistics, Evoked potentials, fMRI & imaging
Keywords: Interoception, Cardiac cycle, Decision-making, fMRI, Go/nogo task, Motivational biases, Neuroscience, Psychology
MeSH: Brain*, Decision Making*, Heart*, Systole*, Female, Humans, Magnetic Resonance Imaging, Male, Motivation (* major topic)
Topic: Neural and Behavioral Psychology Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: MRC (R42105); Wellcome Trust (313662/Z/24/Z); European Research Council (865003)
Citations: not cited yet (Europe PMC); 79 references in the paper

Abstract

Action selection is traditionally thought to be governed by dual top-down control systems: a fast, affect-dependent controller and a slow, experience-driven controller. Emerging evidence indicates that bottom-up cardiac phase signals also contribute to action selection by facilitating (i.e., go) or suppressing (i.e., nogo) motor responses. Despite growing interest in cardiac-brain interactions, no prior study has examined whether cardiac phase effects on feedback-driven action decisions are modulated by appetitive and aversive motivational states. We conducted a secondary analysis of a go/nogo functional magnetic resonance imaging (fMRI) dataset (n = 29), retrospectively determining the onset of decision cues relative to physiologically defined cardiac phases. We tested competing behavioural and computational hypotheses proposing that cardiac phase modulated action selection via motivational action biases, or through a general, affect-independent prepotent urge to act. Additionally, we performed an exploratory fMRI analysis to investigate neural activity underlying action decisions as a function of cardiac phase. Converging behavioural and computational evidence showed that systole was associated with a higher likelihood of go responding, independent of motivational action biases. Preliminary fMRI results further suggested that systolic facilitation of action was accompanied by diminished neural activity supporting action inhibition. Together, these findings extend existing evidence that cardiac phase impacts action decisions.

Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-52930-9.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability

The code used for statistical and computational modelling will be made available upon request to.

Reproduced under the paper's license (CC BY), from the paper cited above.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Data availability

The data presented in this paper will be made available upon request to.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 8 keywords, 9 MeSH terms, 3 funders, 70 references.

Cite

This paper

Queirazza, F., Carvalheiro, J., & Philiastides, M. G. (2026). Cardiac systole is associated with enhanced go responding in an orthogonalized go/nogo task. Scientific reports, 16(1), 23408. https://doi.org/10.1038/s41598-026-52930-9

BibTeX

@article{queirazza2026cardiac,
author = {Queirazza, Filippo and Carvalheiro, Joana and Philiastides, Marios G.},
title = {{Cardiac systole is associated with enhanced go responding in an orthogonalized go/nogo task}},
journal = {Scientific reports},
year = {2026},
month = may,
volume = {16},
number = {1},
pages = {23408},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-52930-9},
url = {https://doi.org/10.1038/s41598-026-52930-9},
pmid = {42168386},
pmcid = {PMC13408127}
}

RIS

TY - JOUR
AU - Queirazza, Filippo
AU - Carvalheiro, Joana
AU - Philiastides, Marios G.
TI - Cardiac systole is associated with enhanced go responding in an orthogonalized go/nogo task
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/05/21
VL - 16
IS - 1
SP - 23408
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-52930-9
UR - https://doi.org/10.1038/s41598-026-52930-9
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41598-026-52930-9",
"type": "article-journal",
"title": "Cardiac systole is associated with enhanced go responding in an orthogonalized go/nogo task",
"container-title": "Scientific reports",
"author": [
{
"family": "Queirazza",
"given": "Filippo"
},
{
"family": "Carvalheiro",
"given": "Joana"
},
{
"family": "Philiastides",
"given": "Marios G."
}
],
"container-title-short": "Sci Rep",
"volume": "16",
"issue": "1",
"page": "23408",
"DOI": "10.1038/s41598-026-52930-9",
"PMID": "42168386",
"PMCID": "PMC13408127",
"ISSN": "2045-2322",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41598-026-52930-9",
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
21
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1111/psyp.70297 [code]
Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.
Journal: Psychophysiology
In common: 10 references
[2] doi:10.1111/psyp.70385 [code]
Exploring EEG and ECG in Music Listening: A Scoping Review.
Journal: Psychophysiology
In common: cognitive, 6 references
[3] doi:10.7554/elife.90013 [code]
Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency.
Journal: eLife
In common: cognitive, 6 references
[4] doi:10.1162/imag.a.1319 [code]
When the inner clock fades: Interoceptive decline and consolidation of phase resetting in cortical rhythms by cardiac events underlie healthy lifespan aging.
Journal: Imaging neuroscience (Cambridge, Mass.)
In common: cognitive, 5 references
[5] doi:10.1111/psyp.70271 [code]
Disentangling Respiratory Phase-Dependent and Phase-Independent Components of Anticipatory Cardiac Deceleration.
Journal: Psychophysiology
In common: cognitive, 4 references
[6] doi:10.1111/psyp.70301
Oscillatory Markers of Interoceptive Attention: Beta Suppression as a Neural Signature of Heartbeat Processing.
Journal: Psychophysiology
In common: cognitive, 4 references
[7] doi:10.1371/journal.pbio.3003767 [code]
Ultrasound neuromodulation reveals distinct roles of the dorsal anterior cingulate cortex and anterior insula in learning.
Journal: PLoS biology
In common: cognitive, 4 references
[8] doi:10.1038/s41467-026-71568-9 [code]
Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula.
Journal: Nature communications
In common: cognitive, 4 references
[9] doi:10.1162/imag.a.1353 [code]
Model-based cardiac field artefact correction for OP-MEG.
Journal: Imaging neuroscience (Cambridge, Mass.)
In common: 4 references
[10] doi:10.1038/s42003-026-10156-5 [code]
Brain-heart interactions in late-onset major depressive disorder revealed by multimodal HRV-driven fMRI.
Journal: Communications biology
In common: fMRI, 3 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.