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Assessment of neurotransmitter-related structural brain changes in borderline personality disorder: an MRI study.

Overview

Authors: Michela Pievani1, Elena Gatti1, Valeria Bracca2,3, Serena Meloni4, Laura Pedrini4, Mariangela Lanfredi4, Giada Bianchetti1, Antonino Carcione5,6, Giuseppe Nicolò5, Antonino Semerari5, Roberto Gasparotti7, Daniele Corbo7, Mauro Magoni8, Juergen Dukart9,10, Barbara Borroni2,11, Enrico Premi8, Roberta Rossi4, CLIMAMITHE Study Group12,13,14,15,16,17,18
ORCID iDs: Valeria Bracca
18 affiliations
  1. Laboratory of Alzheimer’s Neuroimaging and Epidemiology (LANE), IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni, 4, Brescia, 25125 Italy
  2. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
  3. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
  4. Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
  5. Third Centre of Cognitive Psychotherapy-Italian School of Cognitive Psychotherapy (SICC), Rome, Italy
  6. Guglielmo Marconi University, Rome, Italy
  7. Neuroradiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy
  8. Stroke Unit, ASST Spedali Civili Brescia, Brescia, Italy
  9. Institute of Neurosciences and Medicine, Brain & Behaviour (INM-7), Research Centre Juelich, Juelich, Germany
  10. Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
  11. Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
  12. IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
  13. Third Centre of Cognitive Psychotherapy, Rome, Italy
  14. Third Center of Cognitive Psychotherapy and Dipartimento Salute Mentale Roma 5, Rome, Italy
  15. Department of Mental Health, ASST Spedali Civili of Brescia, Brescia, Italy
  16. eCampus University, Novedrate, Como Italy
  17. ASST Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
  18. ASST Spedali Civili, Brescia, Italy
Institutions: Centro San Giovanni di Dio Fatebenefratelli (Italy); University of Brescia (Italy); Marconi University (Italy); Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Italy); Forschungszentrum Jülich (Germany); Heinrich Heine University Düsseldorf (Germany)
Journal: Scientific reports, volume 16, issue 1, article 25406
Dates: received 19 December 2025; accepted 29 May 2026; published online 4 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-56165-6 · PMID 42236891 · PMCID PMC13473668 · OpenAlex W7163373452
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: structural MRI / diffusion (modality), human (organism), clinical / translational (subfield)
Methods: Connectivity, Statistics, Preprocessing, fMRI & imaging
Keywords: Borderline personality disorder, Structural magnetic resonance imaging, Neurotransmitter systems, Diseases, Medical research, Neurology, Neuroscience
MeSH: Borderline Personality Disorder*, Brain*, Gray Matter*, Magnetic Resonance Imaging*, Neurotransmitter Agents*, Adult, Case-Control Studies, Female, Humans, Male, Young Adult (* major topic)
Topic: Personality Disorders and Psychopathology (Clinical Psychology, Psychology), according to OpenAlex
Funding: Ministero della Salute (Ricerca Corrente 2025-2027); Deutsche Forschungsgemeinschaft (549186835)
Citations: not cited yet (Europe PMC); 69 references in the paper
Research resources: org/) and the R studio GUI RRID:SCR_001905

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41598-026-56165-6.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 18 authors, 7 keywords, 11 MeSH terms, 2 funders, 63 references, 1 RRID.

Cite

This paper

Pievani, M., Gatti, E., Bracca, V., Meloni, S., Pedrini, L., Lanfredi, M., Bianchetti, G., Carcione, A., Nicolò, G., Semerari, A., Gasparotti, R., Corbo, D., Magoni, M., Dukart, J., Borroni, B., Premi, E., Rossi, R., & CLIMAMITHE Study Group. (2026). Assessment of neurotransmitter-related structural brain changes in borderline personality disorder: an MRI study. Scientific reports, 16(1), 25406. https://doi.org/10.1038/s41598-026-56165-6

BibTeX

@article{pievani2026assessment,
author = {Pievani, Michela and Gatti, Elena and Bracca, Valeria and Meloni, Serena and Pedrini, Laura and Lanfredi, Mariangela and Bianchetti, Giada and Carcione, Antonino and Nicolò, Giuseppe and Semerari, Antonino and Gasparotti, Roberto and Corbo, Daniele and Magoni, Mauro and Dukart, Juergen and Borroni, Barbara and Premi, Enrico and Rossi, Roberta and {CLIMAMITHE Study Group}},
title = {{Assessment of neurotransmitter-related structural brain changes in borderline personality disorder: an MRI study}},
journal = {Scientific reports},
year = {2026},
month = jun,
volume = {16},
number = {1},
pages = {25406},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-56165-6},
url = {https://doi.org/10.1038/s41598-026-56165-6},
pmid = {42236891},
pmcid = {PMC13473668}
}

RIS

TY - JOUR
AU - Pievani, Michela
AU - Gatti, Elena
AU - Bracca, Valeria
AU - Meloni, Serena
AU - Pedrini, Laura
AU - Lanfredi, Mariangela
AU - Bianchetti, Giada
AU - Carcione, Antonino
AU - Nicolò, Giuseppe
AU - Semerari, Antonino
AU - Gasparotti, Roberto
AU - Corbo, Daniele
AU - Magoni, Mauro
AU - Dukart, Juergen
AU - Borroni, Barbara
AU - Premi, Enrico
AU - Rossi, Roberta
AU - CLIMAMITHE Study Group
TI - Assessment of neurotransmitter-related structural brain changes in borderline personality disorder: an MRI study
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/06/04
VL - 16
IS - 1
SP - 25406
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-56165-6
UR - https://doi.org/10.1038/s41598-026-56165-6
LA - en
ER -

CSL-JSON

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