OSCR

First-principles multiscale modeling of cerebral hemodynamics enables personalized predictions of human brain temperature.

Overview

Authors: Dongsuk Sung1,2,3, Peter A. Kottke4, Benjamin B. Risk5, Jason W. Allen6, Fadi Nahab7, Andrei G. Fedorov4,8, Candace C. Fleischer1,2,8
ORCID iDs: Candace C. Fleischer
  1. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University,Atlanta, GA USA
  2. Department of Radiology and Imaging Sciences, Emory University School of Medicine,Health Sciences Research Building II, 1750 Haygood Dr NE, Atlanta, GA 30322 USA
  3. Present Address: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School,Charlestown, MA USA
  4. Woodruff School of Mechanical Engineering, Georgia Institute of Technology,771 Ferst Dr, Atlanta, GA 30332 USA
  5. Department of Biostatistics and Bioinformatics, Emory University,Atlanta, GA USA
  6. Department of Radiology and Imaging Sciences, Indiana University School of Medicine,Indianapolis, IN USA
  7. Department of Neurology, Emory University School of Medicine,Atlanta, GA USA
  8. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology,Atlanta, GA USA
Institutions: Emory University (United States); Massachusetts General Hospital (United States); Georgia Institute of Technology (United States); Indiana University School of Medicine
Journal: Scientific reports, volume 16, issue 1, article 24183
Dates: received 8 October 2025; accepted 3 June 2026; published online 15 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-56922-7 · PMID 42297991 · PMCID PMC13443945 · OpenAlex W7164816325
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), stroke (population), clinical / translational (subfield)
Methods: Connectivity, fMRI & imaging
Keywords: Biomarkers, Computational biology and bioinformatics, Engineering, Neurology, Neuroscience, Physics
MeSH: Body Temperature*, Brain*, Cerebrovascular Circulation*, Hemodynamics*, Adult, Female, Humans, Magnetic Resonance Imaging, Male, Young Adult (* major topic)
Topic: Thermal Regulation in Medicine (Critical Care and Intensive Care Medicine, Medicine), according to OpenAlex
Funding: American Heart Association; Georgia Institute of Technology; NIH
Citations: not cited yet (Europe PMC); 75 references in the paper
Research resources: RRID:SCR_023522

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41598-026-56922-7.

Tracing map

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Data

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Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41598-026-56922-7.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 6 keywords, 10 MeSH terms, 3 funders, 70 references, 1 RRID.

Cite

This paper

Sung, D., Kottke, P. A., Risk, B. B., Allen, J. W., Nahab, F., Fedorov, A. G., & Fleischer, C. C. (2026). First-principles multiscale modeling of cerebral hemodynamics enables personalized predictions of human brain temperature. Scientific reports, 16(1), 24183. https://doi.org/10.1038/s41598-026-56922-7

BibTeX

@article{sung2026first,
author = {Sung, Dongsuk and Kottke, Peter A. and Risk, Benjamin B. and Allen, Jason W. and Nahab, Fadi and Fedorov, Andrei G. and Fleischer, Candace C.},
title = {{First-principles multiscale modeling of cerebral hemodynamics enables personalized predictions of human brain temperature}},
journal = {Scientific reports},
year = {2026},
month = jun,
volume = {16},
number = {1},
pages = {24183},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-56922-7},
url = {https://doi.org/10.1038/s41598-026-56922-7},
pmid = {42297991},
pmcid = {PMC13443945}
}

RIS

TY - JOUR
AU - Sung, Dongsuk
AU - Kottke, Peter A.
AU - Risk, Benjamin B.
AU - Allen, Jason W.
AU - Nahab, Fadi
AU - Fedorov, Andrei G.
AU - Fleischer, Candace C.
TI - First-principles multiscale modeling of cerebral hemodynamics enables personalized predictions of human brain temperature
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/06/15
VL - 16
IS - 1
SP - 24183
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-56922-7
UR - https://doi.org/10.1038/s41598-026-56922-7
LA - en
ER -

CSL-JSON

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"title": "First-principles multiscale modeling of cerebral hemodynamics enables personalized predictions of human brain temperature",
"container-title": "Scientific reports",
"author": [
{
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"given": "Dongsuk"
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"DOI": "10.1038/s41598-026-56922-7",
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"ISSN": "2045-2322",
"publisher": "Nature Publishing Group",
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"language": "en",
"issued": {
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}

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