OSCR

Sustained Notch activation depletes adult neural stem cells and impairs cognitive function.

Overview

Authors: Nur Azrah Fazera Mohd Ariffin1, Naoko Morimura1, Kenny Daun1,2, Seiji Hitoshi1
ORCID iDs: Nur Azrah Fazera Mohd Ariffin, Kenny Daun
  1. Department of Integrative Physiology, Shiga University of Medical Science,Otsu, Japan
  2. Faculty of Resource Science and Technology, Universiti Malaysia Sarawak,Kota Samarahan, Malaysia
Institutions: Shiga University of Medical Science (Japan); Universiti Malaysia Sarawak (Malaysia)
Journal: Scientific reports, volume 16, issue 1, article 27476
Dates: received 25 February 2026; accepted 4 June 2026; published online 16 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-56980-x · PMID 42303665 · PMCID PMC13534449 · OpenAlex W7164938967
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: behavior only (modality), mouse (organism)
Methods: Statistics, Evoked potentials
Keywords: Notch signaling, Adult neurogenesis, Self-renewal, Olfactory bulb, Dentate gyrus, Developmental biology, Neuroscience, Stem cells
MeSH: Adult Stem Cells*, Cognition*, Neural Stem Cells*, Receptors, Notch*, Animals, Cell Differentiation, Dentate Gyrus, Hippocampus, Male, Mice, Mice, Transgenic, Nestin, Neurogenesis, Olfactory Bulb, Signal Transduction (* major topic)
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: Ministry of Education, Culture, Sports, Science, and Technology of Japan (16H04671, 22K19359); SENSHIN Medical Research Foundation
Citations: not cited yet (Europe PMC); 62 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41598-026-56980-x.

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Data

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Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41598-026-56980-x.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 8 keywords, 15 MeSH terms, 2 funders, 60 references.

Cite

This paper

Mohd Ariffin, N. A. F., Morimura, N., Daun, K., & Hitoshi, S. (2026). Sustained Notch activation depletes adult neural stem cells and impairs cognitive function. Scientific reports, 16(1), 27476. https://doi.org/10.1038/s41598-026-56980-x

BibTeX

@article{mohdariffin2026sustained,
author = {Mohd Ariffin, Nur Azrah Fazera and Morimura, Naoko and Daun, Kenny and Hitoshi, Seiji},
title = {{Sustained Notch activation depletes adult neural stem cells and impairs cognitive function}},
journal = {Scientific reports},
year = {2026},
month = jun,
volume = {16},
number = {1},
pages = {27476},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-56980-x},
url = {https://doi.org/10.1038/s41598-026-56980-x},
pmid = {42303665},
pmcid = {PMC13534449}
}

RIS

TY - JOUR
AU - Mohd Ariffin, Nur Azrah Fazera
AU - Morimura, Naoko
AU - Daun, Kenny
AU - Hitoshi, Seiji
TI - Sustained Notch activation depletes adult neural stem cells and impairs cognitive function
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/06/16
VL - 16
IS - 1
SP - 27476
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-56980-x
UR - https://doi.org/10.1038/s41598-026-56980-x
LA - en
ER -

CSL-JSON

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