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Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment.

Overview

Authors: Aikaterini Lampada1, Chiara Rolando1, Nigel Whittle2, Anna Engler1, Jens Tillmann3, Joana Amorim Freire1, Claudio Giachino1, Elena Parmigiani1, Ichiko Saotome4, Angeliki Louvi4, Jan Gründemann1,3,5, Andreas Lüthi2,6, Verdon Taylor1
ORCID iDs: Aikaterini Lampada, Nigel Whittle, Anna Engler, Jens Tillmann, Claudio Giachino, Elena Parmigiani, Angeliki Louvi, Jan Gründemann, Andreas Lüthi, Verdon Taylor
  1. Department of Biomedicine, University of Basel, Basel, 4058, Switzerland
  2. Friedrich Miescher Institute for Biomedical Research, Basel, 4056, Switzerland
  3. DZNE, Bonn, 53127, Germany
  4. Departments of Neurosurgery and Neuroscience, Yale School of Medicine, New Haven, CT 06520, USA
  5. Medical Faculty, University of Bonn, Bonn, Germany
  6. University of Basel, Basel, Switzerland
Institutions: University of Basel (Switzerland); Friedrich Miescher Institute (Switzerland); German Center for Neurodegenerative Diseases (Germany); Yale University (United States); University of Bonn (Germany)
Journal: Science advances, volume 12, issue 24, article eaed3625
Dates: received 24 October 2025; accepted 4 May 2026; published online 10 June 2026; in print June 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1126/sciadv.aed3625 · PMID 42268980 · PMCID PMC13251870 · OpenAlex W7164187092
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), depression (population), developmental (subfield)
Methods: Preprocessing, Statistics, Machine learning, Evoked potentials, Connectivity, fMRI & imaging
MeSH: Antidepressive Agents*, Interneurons*, Septum of Brain*, Animals, Cell Proliferation, Fear, Fluoxetine, GABAergic Neurons, Male, Mice, Neural Stem Cells, Neurogenesis, Serotonin (* major topic)
Journal subjects: Neuroscience
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: Land Nordrhein-Westfalen (iBehave); Deutsche Forschungsgemeinschaft (German Research Foundation) (SFB1089, SPP2411); Swiss National Science Foundation (310030_143767, 31003A_162609, PP00P3_170672, 320030-227905)
Citations: not cited yet (Europe PMC); 104 references in the paper

Abstract

Adult neurogenesis sustains olfactory function, facilitates the acquisition of new memories, and provides resilience against depression in mice. Neural stem cells (NSCs) elicit selective responses to different physiological and pathological stimuli, thereby modulating neuron production. Here, we show that fear conditioning stimulates neurogenesis in the adult mouse brain septum by activating NSCs in the dorsal septum (dsNSCs) situated near a plexus of serotonergic axons originating from raphe nucleus neurons—key regulators of mood, anxiety, and stress responses. Elevation of serotonin (5HT) levels with the antidepressant and anxiolytic drug fluoxetine similarly promoted dsNSC proliferation and neurogenesis. The adult-born GABAergic interneurons integrate into septal nuclei. These findings suggest a potential adaptive response in mice to stress-inducing aversive experiences and elevated 5HT in the adult septum.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Data, code, and materials availability

This study did not generate new materials. All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/or the Supplementary Materials. Requests for resources and reagents should be directed to and will be fulfilled by the corresponding author, V.T. ().

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 13 MeSH terms, 3 funders, 102 references.

Cite

This paper

Lampada, A., Rolando, C., Whittle, N., Engler, A., Tillmann, J., Freire, J. A., Giachino, C., Parmigiani, E., Saotome, I., Louvi, A., Gründemann, J., Lüthi, A., & Taylor, V. (2026). Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment. Science advances, 12(24), eaed3625. https://doi.org/10.1126/sciadv.aed3625

BibTeX

@article{lampada2026mice,
author = {Lampada, Aikaterini and Rolando, Chiara and Whittle, Nigel and Engler, Anna and Tillmann, Jens and Freire, Joana Amorim and Giachino, Claudio and Parmigiani, Elena and Saotome, Ichiko and Louvi, Angeliki and Gründemann, Jan and Lüthi, Andreas and Taylor, Verdon},
title = {{Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment}},
journal = {Science advances},
year = {2026},
month = jun,
volume = {12},
number = {24},
pages = {eaed3625},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/sciadv.aed3625},
url = {https://doi.org/10.1126/sciadv.aed3625},
pmid = {42268980},
pmcid = {PMC13251870}
}

RIS

TY - JOUR
AU - Lampada, Aikaterini
AU - Rolando, Chiara
AU - Whittle, Nigel
AU - Engler, Anna
AU - Tillmann, Jens
AU - Freire, Joana Amorim
AU - Giachino, Claudio
AU - Parmigiani, Elena
AU - Saotome, Ichiko
AU - Louvi, Angeliki
AU - Gründemann, Jan
AU - Lüthi, Andreas
AU - Taylor, Verdon
TI - Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/06/10
VL - 12
IS - 24
SP - eaed3625
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/sciadv.aed3625
UR - https://doi.org/10.1126/sciadv.aed3625
LA - en
ER -

CSL-JSON

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