Orbitofrontal PV interneurons modulate social interaction via default mode network dynamics.
Overview
- Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany
- Institute for Applied Physiology, Ulm University, Ulm, Germany
Abstract
Social interactions are critical for mental health and are frequently disrupted in neuropsychiatric disorders. Clinical data suggest a link between dysfunction of the default mode network (DMN) and social impairment. To advance our understanding of the neurobiological mechanisms underlying social dysfunction, we back-translate these clinical findings into a preclinical setup, demonstrating that impaired DMN connectivity - achieved through activation of Parvalbumin interneurons in the orbitofrontal cortex (OFC) reduces normal social behaviour.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:30278836, at figshare; found in “Data availability”
Data availability
The experimental data that support the findings of this study are available in Figshare. 10.6084/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 2 keywords, 9 MeSH terms, 2 funders, 68 references.
Cite
This paper
Khatamsaz, E., Ionescu, T. M., Keppler, K., Stoller, F., Kätzel, D., Marston, H. M., & Hengerer, B. (2026). Orbitofrontal PV interneurons modulate social interaction via default mode network dynamics. Communications biology, 9(1), 573. https://
BibTeX
@article{khatamsaz2026or
author = {Khatamsaz, Elmira and Ionescu, Tudor M and Keppler, Katja and Stoller, Franziska and Kätzel, Dennis and Marston, Hugh M and Hengerer, Bastian},
title = {{Orbitofrontal PV interneurons modulate social interaction via default mode network dynamics}},
journal = {Communications biology},
year = {2026},
month = apr,
volume = {9},
number = {1},
pages = {573},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/
url = {https://
pmid = {42032120},
pmcid = {PMC13109428}
}
RIS
TY - JOUR
AU - Khatamsaz, Elmira
AU - Ionescu, Tudor M
AU - Keppler, Katja
AU - Stoller, Franziska
AU - Kätzel, Dennis
AU - Marston, Hugh M
AU - Hengerer, Bastian
TI - Orbitofrontal PV interneurons modulate social interaction via default mode network dynamics
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/
VL - 9
IS - 1
SP - 573
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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"URL": "https://
"language": "en",
"issued": {
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