OSCR

FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans.

Overview

Authors: Umer Saleem Bhat1,2, Siju Surendran1,3, Sharanya H1, Jun Liu4, Yun Xu4, Namra Tasnim1,3, Mohd Faraz Abbas1, Ashwani Bhardwaj2,5, Monika Scholz4, Kavita Babu1
ORCID iDs: Umer Saleem Bhat, Sharanya H, Jun Liu, Monika Scholz, Kavita Babu
  1. Centre for Neuroscience, Indian Institute of Science (IISc),Bangalore, India
  2. Department of Biological Sciences, Indian Institute of Science Education and Research (IISER),Mohali, India
  3. Université de Fribourg,Fribourg, Switzerland
  4. Max Planck Research Group Neural Information Flow, Max Planck Institute for Neurobiology of Behavior – Caesar,Bonn, Germany
  5. Regional Forensic Science Laboratory, Dharamshala, India
Institutions: Indian Institute of Science Bangalore (India); Indian Institute of Science Education and Research Mohali (India); University of Fribourg (Switzerland); Max Planck Institute for Neurobiology of Behavior – caesar (Germany)
Journal: Communications biology, volume 9, issue 1, article 923
Dates: received 22 September 2025; accepted 23 April 2026; published online 5 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s42003-026-10188-x · PMID 42082704 · PMCID PMC13346541 · OpenAlex W4410202958
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.05.02.651881
Status: data only (how the code is found and verified)
Categories: C. elegans (organism), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials
Keywords: Molecular neuroscience, Neurophysiology
MeSH: Behavior, Animal*, Caenorhabditis elegans*, Caenorhabditis elegans Proteins*, Neuropeptides*, Receptors, G-Protein-Coupled*, Receptors, Neuropeptide Y*, Animals, Dopamine, Feeding Behavior, Mutation (* major topic)
Topic: Genetics, Aging, and Longevity in Model Organisms (Aging, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Department of Biotechnology, Ministry of Science and Technology, India (BT/PR24038/BRB/10/1693/2018, BT/HRD-NBA-NWB/38/2019-20); Wellcome Trust DBT India Alliance (IA/S/19/2/504649); Science and Engineering Research Board (CRG/2023/001950, SPG/2022/000182)
Citations: cited by 2 papers (Europe PMC); 60 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data and to no code of its authors: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: OSF kbavs
  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s42003-026-10188-x.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 2 keywords, 10 MeSH terms, 3 funders, 60 references.

Cite

This paper

Bhat, U. S., Surendran, S., H, S., Liu, J., Xu, Y., Tasnim, N., Abbas, M. F., Bhardwaj, A., Scholz, M., & Babu, K. (2026). FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans. Communications biology, 9(1), 923. https://doi.org/10.1038/s42003-026-10188-x

BibTeX

@article{bhat2026flp,
author = {Bhat, Umer Saleem and Surendran, Siju and H, Sharanya and Liu, Jun and Xu, Yun and Tasnim, Namra and Abbas, Mohd Faraz and Bhardwaj, Ashwani and Scholz, Monika and Babu, Kavita},
title = {{FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans}},
journal = {Communications biology},
year = {2026},
month = may,
volume = {9},
number = {1},
pages = {923},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/s42003-026-10188-x},
url = {https://doi.org/10.1038/s42003-026-10188-x},
pmid = {42082704},
pmcid = {PMC13346541}
}

RIS

TY - JOUR
AU - Bhat, Umer Saleem
AU - Surendran, Siju
AU - H, Sharanya
AU - Liu, Jun
AU - Xu, Yun
AU - Tasnim, Namra
AU - Abbas, Mohd Faraz
AU - Bhardwaj, Ashwani
AU - Scholz, Monika
AU - Babu, Kavita
TI - FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/05/05
VL - 9
IS - 1
SP - 923
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/s42003-026-10188-x
UR - https://doi.org/10.1038/s42003-026-10188-x
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s42003-026-10188-x",
"type": "article-journal",
"title": "FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans",
"container-title": "Communications biology",
"author": [
{
"family": "Bhat",
"given": "Umer Saleem"
},
{
"family": "Surendran",
"given": "Siju"
},
{
"family": "H",
"given": "Sharanya"
},
{
"family": "Liu",
"given": "Jun"
},
{
"family": "Xu",
"given": "Yun"
},
{
"family": "Tasnim",
"given": "Namra"
},
{
"family": "Abbas",
"given": "Mohd Faraz"
},
{
"family": "Bhardwaj",
"given": "Ashwani"
},
{
"family": "Scholz",
"given": "Monika"
},
{
"family": "Babu",
"given": "Kavita"
}
],
"container-title-short": "Commun Biol",
"volume": "9",
"issue": "1",
"page": "923",
"DOI": "10.1038/s42003-026-10188-x",
"PMID": "42082704",
"PMCID": "PMC13346541",
"ISSN": "2399-3642",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s42003-026-10188-x",
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
5
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41586-025-10009-x [code]
Predatory aggression evolved through adaptations to noradrenergic circuits.
Journal: Nature
In common: 5 references, 2 authors
[2] doi:10.1093/genetics/iyae125
Adapting and optimizing GCaMP8f for use in Caenorhabditis elegans.
Journal: Genetics
In common: C. elegans, cellular / molecular, 2 references, 2 authors
[3] doi:10.1016/j.celrep.2023.113058
System-wide mapping of peptide-GPCR interactions in C. elegans.
Journal: Cell reports
In common: C. elegans, cellular / molecular, 8 references
[4] doi:10.1016/j.neuron.2023.09.043 [code]
The neuropeptidergic connectome of C. elegans.
Journal: Neuron
In common: C. elegans, cellular / molecular, 7 references
[5] doi:10.1038/s41467-024-53899-7 [code]
Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair.
Journal: Nature communications
In common: C. elegans, cellular / molecular, 7 references
[6] doi:10.1016/j.isci.2024.109390
CKR-1 orchestrates two motor states from a single motoneuron in <i>C. elegans</i>.
Journal: iScience
In common: C. elegans, 6 references
[7] doi:10.1126/sciadv.adu5829
Food sensing controls &lt;i&gt;C. elegans&lt;/i&gt; reproductive behavior by neuromodulatory disinhibition.
Journal: Science advances
In common: C. elegans, 7 references
[8] doi:10.64898/2026.01.09.698615 [code]
Autocrine feedback maintains homeostatic neuropeptide expression in a peptidergic hub neuron
Journal: bioRxiv (preprint)
In common: cellular / molecular, 7 references
[9] doi:10.1093/g3journal/jkaf086 [code]
Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans.
Journal: G3 (Bethesda, Md.)
In common: C. elegans, 7 references
[10] doi:10.1073/pnas.2219341120 [code]
A proprioceptive feedback circuit drives <i>Caenorhabditis elegans</i> locomotor adaptation through dopamine signaling.
Journal: Proceedings of the National Academy of Sciences of the United States of America
In common: C. elegans, 6 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: code errors and mismatches between the code and the paper about this paper and its code, from readers and its authors, beside the paper and its tracing map.

Reproductions: reports from readers who ran the authors' code and did not get the paper's result, what they ran, with which environment, commit and data.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.