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Efficient and specific selection of high-affinity DNA aptamers targeting μ-opioid receptor via functional extracellular vesicles.

Overview

Authors: Mitsushi J Ikemoto1,2,3, Yuji Kamikubo4, Daisuke Uta5, Kengo Kirinoki6, Mari Kiriyama7, Takumi Miyajima7, Hakushun Sakairi4, Masanobu Kano8, Takashi Sakurai4, Toshihide Tabata9
ORCID iDs: Mitsushi J Ikemoto, Yuji Kamikubo, Daisuke Uta, Mari Kiriyama, Masanobu Kano, Takashi Sakurai, Toshihide Tabata
  1. Department of Engineering, University of Toyama, Toyama, Japan
  2. Institute of Health and Sports Sciences, University of Tsukuba, Ibaraki, Japan
  3. Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan
  4. Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan
  5. Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan
  6. Graduate School of Science and Engineering, University of Toyama, Toyama, Japan
  7. Interdisciplinary Graduate School of Medicine, Pharmacy, Science and Engineering, University of Toyama, Toyama, Japan
  8. International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, Japan
  9. Faculty of Engineering, University of Toyama, Toyama, Japan
Institutions: University of Tsukuba (Japan); University of Toyama (Japan); National Institute of Advanced Industrial Science and Technology (Japan); Juntendo University (Japan); The University of Tokyo (Japan)
Journal: Communications biology, volume 9, issue 1, article 861
Dates: received 1 July 2025; accepted 11 June 2026; published online 7 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s42003-026-10525-0 · PMID 42414537 · PMCID PMC13342530 · OpenAlex W7167607546
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), pain (population), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials
Keywords: Nucleic-acid therapeutics
MeSH: Aptamers, Nucleotide*, Extracellular Vesicles*, Receptors, Opioid, mu*, SELEX Aptamer Technique*, Animals, Humans, Male, Mice, Neurons (* major topic)
Topic: Advanced biosensing and bioanalysis techniques (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: MEXT | Japan Society for the Promotion of Science (JSPS) (KAKENHI 19K09323, KAKENHI 23K06170, KAKENHI 15K14985, KAKENHI 22K07319, KAKENHI 25K10602)
Citations: not cited yet (Europe PMC); 49 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s42003-026-10525-0.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 1 keyword, 9 MeSH terms, 1 funder, 49 references.

Cite

This paper

Ikemoto, M. J., Kamikubo, Y., Uta, D., Kirinoki, K., Kiriyama, M., Miyajima, T., Sakairi, H., Kano, M., Sakurai, T., & Tabata, T. (2026). Efficient and specific selection of high-affinity DNA aptamers targeting μ-opioid receptor via functional extracellular vesicles. Communications biology, 9(1), 861. https://doi.org/10.1038/s42003-026-10525-0

BibTeX

@article{ikemoto2026efficient,
author = {Ikemoto, Mitsushi J and Kamikubo, Yuji and Uta, Daisuke and Kirinoki, Kengo and Kiriyama, Mari and Miyajima, Takumi and Sakairi, Hakushun and Kano, Masanobu and Sakurai, Takashi and Tabata, Toshihide},
title = {{Efficient and specific selection of high-affinity DNA aptamers targeting μ-opioid receptor via functional extracellular vesicles}},
journal = {Communications biology},
year = {2026},
month = jul,
volume = {9},
number = {1},
pages = {861},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/s42003-026-10525-0},
url = {https://doi.org/10.1038/s42003-026-10525-0},
pmid = {42414537},
pmcid = {PMC13342530}
}

RIS

TY - JOUR
AU - Ikemoto, Mitsushi J
AU - Kamikubo, Yuji
AU - Uta, Daisuke
AU - Kirinoki, Kengo
AU - Kiriyama, Mari
AU - Miyajima, Takumi
AU - Sakairi, Hakushun
AU - Kano, Masanobu
AU - Sakurai, Takashi
AU - Tabata, Toshihide
TI - Efficient and specific selection of high-affinity DNA aptamers targeting μ-opioid receptor via functional extracellular vesicles
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/07/07
VL - 9
IS - 1
SP - 861
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/s42003-026-10525-0
UR - https://doi.org/10.1038/s42003-026-10525-0
LA - en
ER -

CSL-JSON

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