OSCR

Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter.

Overview

Authors: Chase M Carver1,2, Paul T Gomez1,2, Sonia L Rodriguez1,2, James T Redden1,2, Amanda S Latham1,2, Yooree Ha1,2, Jennifer M Kachergus3, Yi Liu4, Ji Shi3, Tommy Tran5, Liguo Wang6, Simon Melov5, E A Thompson3, Marissa J Schafer1,2,7,8
ORCID iDs: Chase M Carver, Paul T Gomez, Yi Liu, Simon Melov, E A Thompson, Marissa J Schafer
  1. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN USA
  2. Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN USA
  3. Department of Cancer Biology, Mayo Clinic, Jacksonville, FL USA
  4. Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL USA
  5. Buck Institute for Research on Aging, Novato, CA USA
  6. Division of Computational Biology, Mayo Clinic College of Medicine, Rochester, MN USA
  7. Department of Neurology, Mayo Clinic, Rochester, MN USA
  8. Department of Neuroscience, Mayo Clinic, Rochester, MN USA
Institutions: Mayo Clinic (United States); Mayo Clinic in Florida (United States); Mayo Clinic Comprehensive Cancer Center (Florida); Buck Institute for Research on Aging (United States)
Journal: Nature aging, volume 6, issue 7, pages 1417-1436
Dates: received 20 December 2023; accepted 28 May 2026; published online 13 July 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s43587-026-01154-7 · PMID 42443609 · PMCID PMC13375653 · OpenAlex W7168121294
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions, Connectivity, Machine learning
Keywords: Microglia, Ageing, Cellular neuroscience
MeSH: Aging*, Microglia*, Senotherapeutics*, White Matter*, Animals, Brain, Galectin 3, Gene Expression Profiling, Male, Mice, Spatial Transcriptomics (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: NIA NIH HHS (U54 AG079779, U54 AG079754, P30 AG068345, R00 AG058798); U.S. Department of Health & Human Services | National Institutes of Health (NIH) (UH3/UG3 CA275669); NIGMS NIH HHS (T32 GM145408); NCI NIH HHS (UH3 CA275669)
Citations: cited by 1 paper (Europe PMC); 75 references in the paper
Research resources: goat polyclonal anti-IBA1 RRID:AB_2224402, RRID:AB_2832971, RRID:AB_837133, rabbit polyclonal anti-IBA1 RRID:AB_839504, goat polyclonal anti-GFAP RRID:AB_880202

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s43587-026-01154-7.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Nature Portfolio

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 3 keywords, 11 MeSH terms, 4 funders, 74 references, 5 RRIDs.

Cite

This paper

Carver, C. M., Gomez, P. T., Rodriguez, S. L., Redden, J. T., Latham, A. S., Ha, Y., Kachergus, J. M., Liu, Y., Shi, J., Tran, T., Wang, L., Melov, S., Thompson, E. A., & Schafer, M. J. (2026). Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter. Nature aging, 6(7), 1417-1436. https://doi.org/10.1038/s43587-026-01154-7

BibTeX

@article{carver2026spatial,
author = {Carver, Chase M and Gomez, Paul T and Rodriguez, Sonia L and Redden, James T and Latham, Amanda S and Ha, Yooree and Kachergus, Jennifer M and Liu, Yi and Shi, Ji and Tran, Tommy and Wang, Liguo and Melov, Simon and Thompson, E A and Schafer, Marissa J},
title = {{Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter}},
journal = {Nature aging},
year = {2026},
month = jul,
volume = {6},
number = {7},
pages = {1417--1436},
publisher = {Nature Portfolio},
issn = {2662-8465},
doi = {10.1038/s43587-026-01154-7},
url = {https://doi.org/10.1038/s43587-026-01154-7},
pmid = {42443609},
pmcid = {PMC13375653}
}

RIS

TY - JOUR
AU - Carver, Chase M
AU - Gomez, Paul T
AU - Rodriguez, Sonia L
AU - Redden, James T
AU - Latham, Amanda S
AU - Ha, Yooree
AU - Kachergus, Jennifer M
AU - Liu, Yi
AU - Shi, Ji
AU - Tran, Tommy
AU - Wang, Liguo
AU - Melov, Simon
AU - Thompson, E A
AU - Schafer, Marissa J
TI - Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter
T2 - Nature aging
J2 - Nat Aging
PY - 2026
DA - 2026/07/13
VL - 6
IS - 7
SP - 1417
EP - 1436
SN - 2662-8465
PB - Nature Portfolio
DO - 10.1038/s43587-026-01154-7
UR - https://doi.org/10.1038/s43587-026-01154-7
LA - en
ER -

CSL-JSON

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