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Thalamic organization differentially contributes to clinical conditions in epilepsy.

Code ↔ Paper

8 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 8 matches · 3 of them tie a paragraph to a whole file without given lines: weak matches, whose lines are not tinted
  1. [1] § Materials and methods › Resting-state fMRI measures ↔ Coinfluence_Maps_Analysis.m, lines 71 to 98 · score 0.75 · LocE, PartC, ReHo, redundancy, focal, recruitment · Report a mismatch
  2. [2] § Materials and methods › Resting-state fMRI measures ↔ Measurements/efficiency_wei.m, lines 1 to 106 · score 0.72 · clustering coefficient, adjacency matrices, local efficiency, algorithm, node, network · Report a mismatch
  3. [3] § Materials and methods › Resting-state fMRI measures ↔ Coinfluence_Maps_Analysis.m, lines 71 to 98 · score 0.70 · LocE, PartC, ReHo, recruitment, DC, MC · Report a mismatch
  4. [4] § Materials and methods › Resting-state fMRI measures ↔ Energy Efficiency/pipelineCompareStaticDynamicEnergy.m, the whole file · a weak match · score 0.67 · control nodes, functional connectivity, static, energy, dynamic, window · Report a mismatch
  5. [5] § Materials and methods › Resting-state fMRI measures ↔ Measurements/regional_activation_energy.m, the whole file · a weak match · score 0.57 · regional activation energy, efficiency, brain, matrix, connectome · Report a mismatch
  6. [6] § Materials and methods › Resting-state fMRI measures ↔ Measurements/regional_activation_energy.m, the whole file · a weak match · score 0.53 · Regional activation energy, brain · Report a mismatch
  7. [7] § Materials and methods › Statistics and reproducibility › Statistical determination of co-influences across TLE clinical “conditions” ↔ permutools/booteffectsize.m, lines 1 to 60 · score 0.52 · pooled standard deviation, confidence intervals, Hedges, Permutools · Report a mismatch
  8. [8] § Materials and methods › Data preprocessing ↔ Coinfluence_Maps_Analysis.m, lines 103 to 220 · score 0.51 · head motion, atlas, AAL, parcel, metrics, pre · Report a mismatch

Paper

Loaded from Europe PMC by your browser; OSCR does not store it: doi.org · Europe PMC

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The authors' code

MATLAB · 264 lines · 10 KB · no license · 3 matches

  1. %% =========================================================================
  2. % Coinfluence Maps Analysis Pipeline
  3. % Temporal Lobe Epilepsy – Multicondition Effect-Size Mapping
  4. % Author: Qirui Zhang
  5. %
  6. % Requirements:
  7. % - PERMUTOOLS: https://github.com/mickcrosse/PERMUTOOLS
  8. % - SurfStat: https://math.mcgill.ca/keith/surfstat/
  9. %
  10. % Input:
  11. % - TLE_Pre_Post_Dataset_Anonymous (Excel)
  12. % - measures.mat (contains Data_pre, Data_post, Data_delta)
  13. % - AAL atlas NIfTI
  14. % =========================================================================
  15. clear; clc;
  16. %% -------------------------------------------------------------------------
  17. % 0. Paths & Output Directories
  18. %% -------------------------------------------------------------------------
  19. result_dir = './Coinfluence_Maps/';
  20. dir_each = fullfile(result_dir, 'condition_level_maps');
  21. dir_summary = fullfile(result_dir, 'summary_maps');
  22. if ~exist(result_dir, 'dir'); mkdir(result_dir); end
  23. if ~exist(dir_each, 'dir'); mkdir(dir_each); end
  24. if ~exist(dir_summary, 'dir'); mkdir(dir_summary); end
  25. %% -------------------------------------------------------------------------
  26. % 1. Load Subject Information
  27. %% -------------------------------------------------------------------------
  28. [NUM,TXT,RAW] = xlsread('./TLE_Pre_Post_Dataset_Anonymous','include_pre');
  29. SUB = unique(RAW(2:end,1)); % subject ID
  30. group = RAW(2:end,6); % overall group
  31. group_TLE = RAW(2:end,7); % TLE vs HC
  32. age = cell2mat(RAW(2:end,9));
  33. sex = RAW(2:end,3);
  34. hm = cell2mat(RAW(2:end,2)); % head motion
  35. outcome = RAW(2:end,20); % Engel (G1 poor, G2 good)
  36. pathology = RAW(2:end,19); % HS vs non-HS
  37. focality = RAW(2:end,17); % focal vs FBTCS
  38. ALL_index = 1:length(SUB);
  39. TLE_index = find(strcmp(group_TLE,'G1'));
  40. HC_index = find(strcmp(group_TLE,'G2'));
  41. good_idx = find(strcmp(outcome,'G2'));
  42. poor_idx = find(strcmp(outcome,'G1'));
  43. %% -------------------------------------------------------------------------
  44. % 2. Load imaging measures (structures)
  45. %% -------------------------------------------------------------------------
  46. load('./measures.mat'); % Data_pre, Data_post, Data_delta (each has .AAL and .combine)
  47. %% -------------------------------------------------------------------------
  48. % 3. Atlas information
  49. %% -------------------------------------------------------------------------
  50. atlas_nii = './aal193_229_193.nii';
  51. aal_order = 1:116;
  52. exclude_ROI = load('.\exculde_ROI_FILP.txt');
  53. %% -------------------------------------------------------------------------
  54. % 4. Define Measures & Clinical Conditions
  55. %% -------------------------------------------------------------------------
  56. % Nine non-redundant imaging metrics
  57. measure_list = {'ALFF','ReHo','GM','Intergration','Recruitment','DC','LocE','PartC','MC'};
  58. % Six conditions
  59. condition_labels = { ...
  60. 'P1_TLE_vs_HC', ... % pre-surgical organization: TLE vs HC
  61. 'P2_Post_vs_Pre', ... % post-surgical organization: post vs pre
  62. 'Outcome_Poor_vs_Good', ... % seizure outcome
  63. 'Seizure_Focality', ... % focal vs FBTCS
  64. 'Pathology', ... % HS vs non-HS
  65. 'Laterality'}; % seizure onset lateralization
  66. condition_var = { ...
  67. 'group_TLE', ... % P1: TLE vs HC
  68. 'group_TLE', ... % P2: paired TLE pre/post
  69. 'outcome', ... % poor vs good
  70. 'focality', ... % focal vs FBTCS
  71. 'pathology', ... % HS vs non-HS
  72. 'group'}; % left vs right
  73. condition_index = { ...
  74. ALL_index, ... % P1: all (TLE+HC)
  75. TLE_index, ... % P2: only TLE with pre/post
  76. TLE_index, ... % outcome: TLE only
  77. TLE_index, ... % focality: TLE only
  78. TLE_index, ... % pathology: TLE only
  79. TLE_index}; % lateralization: TLE only
  80. %% -------------------------------------------------------------------------
  81. % 5. Main Loop – Condition × Measure
  82. %% -------------------------------------------------------------------------
  83. n_roi = 116;
  84. n_cond = numel(condition_labels);
  85. n_measure = numel(measure_list);
  86. D_all = zeros(n_roi, n_cond, n_measure);
  87. P_all = zeros(n_roi, n_cond, n_measure);
  88. for ci = 1:n_cond
  89. idx_cond = condition_index{ci};
  90. % covariates for current condition
  91. ageI = age(idx_cond);
  92. sexI = sex(idx_cond);
  93. hmI = hm(idx_cond);
  94. AgeTerm = term(ageI);
  95. SexTerm = term(sexI);
  96. HMTerm = term(hmI);
  97. cond_raw = eval(condition_var{ci});
  98. cond_raw = cond_raw(idx_cond);
  99. CondTerm = term(cond_raw);
  100. % for independent-sample comparisons, define G1/G2
  101. G1_idx = find(strcmp(cond_raw,'G1'));
  102. if ci ~= 2 % P2 is paired, no G2
  103. G2_idx = find(strcmp(cond_raw,'G2'));
  104. end
  105. for mi = 1:n_measure
  106. metric_name = measure_list{mi};
  107. % -----------------------------------------------------------------
  108. % 5.1 Select data matrix used in linear model
  109. % P2(Post_vs_Pre) uses Data_delta, others use Data_pre
  110. % -----------------------------------------------------------------
  111. if ci == 2
  112. data_model = Data_delta.AAL.(metric_name); % 116 × subj
  113. else
  114. data_model = Data_pre.AAL.(metric_name); % 116 × subj
  115. end
  116. data_model = data_model(:, idx_cond); % 116 × nCondSubj
  117. % -----------------------------------------------------------------
  118. % 5.2 Fit linear model and compute t-map
  119. % -----------------------------------------------------------------
  120. if ci == 2
  121. % Paired design (post – pre)
  122. M = CondTerm; % dummy term for completeness
  123. slm = SurfStatLinMod(data_model', M);
  124. slmp = SurfStatT(slm, CondTerm); % not actually used for contrast coding
  125. % ---- effect size: post vs pre (paired) ----
  126. data_pre_roi = Data_pre.AAL.(metric_name);
  127. data_post_roi = Data_post.AAL.(metric_name);
  128. data_pre_roi = data_pre_roi(:, idx_cond);
  129. data_post_roi = data_post_roi(:, idx_cond);
  130. data_post_roi(exclude_ROI==1,:) = 0;
  131. data_pre_roi(exclude_ROI==1,:) = 0;
  132. [d, d_ci] = booteffectsize( ...
  133. data_post_roi', data_pre_roi', ...
  134. 'effect','cohen','paired',1,'correct',1);
  135. [~, p_val] = ttest(data_post_roi', data_pre_roi');
  136. % mask out resected temporal parcels
  137. slmp.t(exclude_ROI==1) = 0;
  138. slmp.p = p_val(:)';
  139. slmp.p(exclude_ROI==1) = 1;
  140. else
  141. % Independent-sample tests with covariates
  142. M_full = 1 + CondTerm + AgeTerm + SexTerm + HMTerm;
  143. slm = SurfStatLinMod(data_model', M_full);
  144. slmp = SurfStatT(slm, CondTerm.G1 - CondTerm.G2);
  145. % residuals after regressing out age, sex, head motion
  146. M_cov = 1 + AgeTerm + SexTerm + HMTerm;
  147. slm_cov = SurfStatLinMod(data_model', M_cov);
  148. residuals = data_model' - slm_cov.X * slm_cov.coef;
  149. res_G1 = residuals(G1_idx,:);
  150. res_G2 = residuals(G2_idx,:);
  151. [d, d_ci] = booteffectsize( ...
  152. res_G1, res_G2, ...
  153. 'effect','cohen','paired',0,'correct',1);
  154. slmp.p = 2 * (1 - tcdf(abs(slmp.t), slmp.df));
  155. end
  156. slmp.d = d;
  157. slmp.d_ci = d_ci;
  158. % -----------------------------------------------------------------
  159. % 5.3 Save NIfTI and .mat for this condition × metric
  160. % -----------------------------------------------------------------
  161. out_nii = fullfile(dir_each, ...
  162. sprintf('%s_%s_d.nii', condition_labels{ci}, metric_name));
  163. parcel_to_volume(slmp.d, atlas_nii, out_nii, aal_order);
  164. out_mat = fullfile(dir_each, ...
  165. sprintf('%s_%s_stats.mat', condition_labels{ci}, metric_name));
  166. save(out_mat, 'slmp');
  167. % collect into big arrays for summary maps
  168. D_all(:, ci, mi) = slmp.d(:);
  169. P_all(:, ci, mi) = slmp.p(:);
  170. end
  171. end
  172. save(fullfile(result_dir, 'D_all.mat'), 'D_all', 'P_all');
  173. %% -------------------------------------------------------------------------
  174. % 6. Summary Maps – Mean Absolute Effect Size Across Measures
  175. % --------------------------------------------------------------------------
  176. % 6.1 All 6 conditions × 9 measures
  177. D_flat = reshape(D_all, [n_roi, numel(D_all)/n_roi]);
  178. mean_d_all = mean(abs(D_flat), 2, 'omitnan');
  179. parcel_to_volume(mean_d_all, atlas_nii, ...
  180. fullfile(dir_summary, 'Mean_d_all_conditions.nii'), aal_order);
  181. % 6.2 Pre-surgical conditions only (exclude P2 Post_vs_Pre)
  182. D_sel = D_all(:, [1 3 4 5 6], :); % 5 conditions × 9 measures
  183. D_sel_flat = reshape(D_sel, [n_roi, numel(D_sel)/n_roi]);
  184. mean_d_pre = mean(abs(D_sel_flat), 2, 'omitnan');
  185. parcel_to_volume(mean_d_pre, atlas_nii, ...
  186. fullfile(dir_summary, 'Mean_d_pre_surgical_conditions.nii'), aal_order);
  187. % 6.3 Condition-specific summary maps – Mean |d| across metrics (per condition)
  188. % Naming convention for each clinical condition (used in output filenames)
  189. condition_type_name = {'P1_TLE_HC', ...
  190. 'P2_Post_Pre', ...
  191. 'Outcome_poor_good', ...
  192. 'Seizure_Focality_FBTCS+_FBTCS-', ...
  193. 'Pathology_HS_nHS', ...
  194. 'Laterality_Left_Right'};
  195. mean_d_each = zeros(n_roi, n_cond);
  196. for ci = 1:n_cond
  197. % Mean absolute effect size across all 9 metrics for this condition
  198. mean_d_each(:, ci) = mean(abs(D_all(:, ci, :)), 3, 'omitnan');
  199. % Save condition-specific mean |d| map to summary_maps/
  200. out_nii = fullfile(dir_summary, ...
  201. sprintf('%s_Mean_d.nii', condition_type_name{ci}));
  202. parcel_to_volume(mean_d_each(:, ci), atlas_nii, out_nii, aal_order);
  203. end

Coinfluence_Maps_Analysis.m, no license · at the source

Overview

Authors: Qirui Zhang1, Sam S. Javidi1, Ankeeta Ankeeta1, Michael R. Sperling1, Zhiqiang Zhang2, Joseph I. Tracy1
  1. Farber Institute for Neuroscience, Department of Neurology, Thomas Jefferson University,Philadelphia, PA USA
  2. Department of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University,Nanjing, Jiangsu China
Institutions: Thomas Jefferson University (United States); Nanjing University (China)
Journal: Communications medicine, volume 6, issue 1, article 281
Dates: received 7 July 2025; accepted 10 March 2026; published online 24 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s43856-026-01530-9 · PMID 41876841 · PMCID PMC13183871 · OpenAlex W7140193856
Open access: gold, a free copy (OpenAlex)
Status: code verified (how the code is found and verified)
Categories: structural MRI / diffusion (modality), human (organism), epilepsy (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Connectivity, Statistics, Machine learning, Preprocessing, Graphs, fMRI & imaging, Smoothing, state filtering, decompositions
Keywords: Epilepsy, Cognitive neuroscience
Topic: Functional Brain Connectivity Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: Epilepsy Society; National Institutes of Health
Citations: cited by 1 paper (Europe PMC); 67 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repositories

Its files are read in the Code ↔ Paper reader above, with 8 matches between paragraphs and lines of code.

OSF 49xde

License: none: the authors keep all their rights
State: the link answers, verified on 30 September 2026
Evidence: files inventoried
Languages: MATLAB (2)
Size: 9 files, 2 scripts
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: the link answers (HTTP 200)
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2 files
At the source: osf.io/49xde/

xiaosonghe/DynamicFunctionalConnectivity

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State: the link answers, verified on 30 September 2026
Evidence: files inventoried
Commit: 79bda4f73695624314a4a9699856e20ac551ef25, 2 May 2020
Languages: MATLAB (8)
Size: 9 files, 8 scripts
Software Heritage: not archived
Found in: “Code availability”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: Wavelet Toolbox (3 files), SPM (3 files), Brain Connectivity Toolbox (1 file)
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9 files

brain-intelligence-lab/functional_controllability

License: MIT
State: the link answers, verified on 30 September 2026
Evidence: files inventoried
Commit: 323786d6f1249205bed2a3614818dc646a5ae1d5, 2 July 2022
Languages: MATLAB (17), Python (2)
Size: 27 files, 19 scripts
Software Heritage: archived
Found in: “Code availability”
Holds: README, license file
Not found: CITATION.cff, environment file, tests, continuous integration, documentation
Tools: Statistics and Machine Learning Toolbox (2 files), NumPy (2 files), scikit-learn (2 files), SciPy (2 files)
Availability: 1 check, the latest on 30 September 2026: the link answers
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21 files

mickcrosse/PERMUTOOLS

License: BSD-3-Clause
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Evidence: files inventoried
Commit: 3ef0667900e4ee93bb3b0543078c6dd2702c3ade, 21 August 2026
Languages: MATLAB (65)
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Software Heritage: not archived
Found in: “Code availability”
Holds: README, license file, tests, documentation
Not found: CITATION.cff, environment file, continuous integration
Availability: 1 check, the latest on 30 September 2026: the link answers
  • 30 September 2026: the link answers
67 files

Code availability statement

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Read it in the paper: doi.org/10.1038/s43856-026-01530-9.

Tracing map

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  • 4 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
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Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 2 keywords, 2 funders, 65 references.

Cite

This paper

Zhang, Q., Javidi, S. S., Ankeeta, A., Sperling, M. R., Zhang, Z., & Tracy, J. I. (2026). Thalamic organization differentially contributes to clinical conditions in epilepsy. Communications medicine, 6(1), 281. https://doi.org/10.1038/s43856-026-01530-9

BibTeX

@article{zhang2026thalamic,
author = {Zhang, Qirui and Javidi, Sam S. and Ankeeta, Ankeeta and Sperling, Michael R. and Zhang, Zhiqiang and Tracy, Joseph I.},
title = {{Thalamic organization differentially contributes to clinical conditions in epilepsy}},
journal = {Communications medicine},
year = {2026},
month = mar,
volume = {6},
number = {1},
pages = {281},
publisher = {Nature Publishing Group},
issn = {2730-664X},
doi = {10.1038/s43856-026-01530-9},
url = {https://doi.org/10.1038/s43856-026-01530-9},
pmid = {41876841},
pmcid = {PMC13183871}
}

RIS

TY - JOUR
AU - Zhang, Qirui
AU - Javidi, Sam S.
AU - Ankeeta, Ankeeta
AU - Sperling, Michael R.
AU - Zhang, Zhiqiang
AU - Tracy, Joseph I.
TI - Thalamic organization differentially contributes to clinical conditions in epilepsy
T2 - Communications medicine
J2 - Commun Med (Lond)
PY - 2026
DA - 2026/03/24
VL - 6
IS - 1
SP - 281
SN - 2730-664X
PB - Nature Publishing Group
DO - 10.1038/s43856-026-01530-9
UR - https://doi.org/10.1038/s43856-026-01530-9
LA - en
ER -

CSL-JSON

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"container-title": "Communications medicine",
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"given": "Qirui"
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{
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"page": "281",
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"PMCID": "PMC13183871",
"ISSN": "2730-664X",
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"date-parts": [
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   :alt: OSCR

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