Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA.
Overview
- Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Munich, Germany
- Laboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary
- Department of Systems Immunology and Proteomics, Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany
- Core Facility Translational Proteomics, Institute of innate Immunity, University Hospital Bonn, Bonn, Germany
- Julius-Maximilians University of Würzburg, Rudolf Virchow Center for Integrative and Translational Bioimaging and University Hospital Würzburg, Würzburg, Germany
- Medizinische Klinik und Poliklinik I, LMU University Hospital, Munich, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
- Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
- University of Gothenburg, The Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Mölndal and Gothenburg, Gothenburg, Sweden
- Mercator Fellow, Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany
Abstract
Our research presents a new animal model of transient ischemic attack (TIA) that mimics brief episodes without cell loss, but results in neuronal and behavioral deficits. We identified excessive microglial reactivity, driven by acute ATP release, as a key factor in post-TIA neurological deficits, which were ameliorated by inhibiting the P2Y12 receptor, a microglia-specific purinergic receptor in the brain parenchyma responsible for activity-dependent microglial cell-cell interactions. This finding suggests that modulation of microglial reactivity offers a promising strategy to prevent cognitive impairment in TIA patients, opening avenues for future research in this underexplored area.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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The paper's code and data availability statement is in the Data section.
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Data
Datasets cited
- biostudies:S-BIAD2496, at BioStudies; found in “Data availability”
- geo:GSE272954, at NCBI GEO; found in “Data availability”
Other data links
- ebi.ac.uk/
biostudies/ , EMBL-EBI; found in the text, “Author contributions”sourcedata
Data availability
The datasets and computer code produced in this study are available in the following databases: scRNAseq data: Gene Expression Omnibus GSE272954 (https://
The source data of this paper are collected in the following database record: biostudies:S-SCDT-10_103
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 6 keywords, 10 MeSH terms, 1 funder, 58 references.
Cite
This paper
Llovera, G., Heindl, S., Varga, D. P., Lenart, N., Kallabis, S., Göb, V., Stegner, D., Escaig, R., Nicolai, L., Franzmeier, N., Meissner, F., Denes, A., & Liesz, A. (2026). Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA. EMBO molecular medicine, 18(4), 1150-1173. https://
BibTeX
@article{llovera2026bloc
author = {Llovera, Gemma and Heindl, Steffanie and Varga, Daniel P and Lenart, Nikolett and Kallabis, Sebastian and Göb, Vanessa and Stegner, David and Escaig, Raphael and Nicolai, Leo and Franzmeier, Nicolai and Meissner, Felix and Denes, Adam and Liesz, Arthur},
title = {{Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA}},
journal = {EMBO molecular medicine},
year = {2026},
month = mar,
volume = {18},
number = {4},
pages = {1150--1173},
publisher = {Nature Publishing Group},
issn = {1757-4676},
doi = {10.1038/
url = {https://
pmid = {41862768},
pmcid = {PMC13083932}
}
RIS
TY - JOUR
AU - Llovera, Gemma
AU - Heindl, Steffanie
AU - Varga, Daniel P
AU - Lenart, Nikolett
AU - Kallabis, Sebastian
AU - Göb, Vanessa
AU - Stegner, David
AU - Escaig, Raphael
AU - Nicolai, Leo
AU - Franzmeier, Nicolai
AU - Meissner, Felix
AU - Denes, Adam
AU - Liesz, Arthur
TI - Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA
T2 - EMBO molecular medicine
J2 - EMBO Mol Med
PY - 2026
DA - 2026/
VL - 18
IS - 4
SP - 1150
EP - 1173
SN - 1757-4676
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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