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3D epithelial cell topology tunes signaling range to promote precise patterning.

Code ↔ Paper

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Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

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The authors' code

Python · 31 lines · 661 B · MIT

  1. from datetime import datetime
  2. import os
  3. import sys
  4. sys.path.insert(0, os.path.abspath("../../src"))
  5. project = "MultiLayer-NotchDelta"
  6. author = "Francisco Berkemeier"
  7. copyright = f"{datetime.now().year}, {author}"
  8. release = "0.1.0"
  9. extensions = [
  10. "sphinx.ext.autodoc",
  11. "sphinx.ext.napoleon",
  12. "sphinx.ext.viewcode",
  13. "sphinx_copybutton",
  14. "myst_parser",
  15. ]
  16. templates_path = ["_templates"]
  17. exclude_patterns = [".ipynb_checkpoints", "**/.ipynb_checkpoints"]
  18. html_theme = "sphinx_rtd_theme"
  19. html_static_path = ["_static"]
  20. html_theme_options = {
  21. "version_selector": False,
  22. "language_selector": False,
  23. "flyout_display": "hidden",
  24. }

conf.py at commit 3b57131, under MIT · at the source

Overview

  1. Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
  2. Institute for the Physics of Living Systems, University College London, London WC1E 6BT, United Kingdom
  3. Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
  4. Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
  5. Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
  6. Department of Mathematics, University College London, London WC1E 6BT, United Kingdom
Institutions: University College London (United Kingdom); University of Cambridge (United Kingdom); MRC Laboratory of Molecular Biology (United Kingdom); Medical Research Council (United Kingdom)
Dates: received 18 August 2025; accepted 30 March 2026; published online 6 May 2026; in print 12 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2522727123 · PMID 42090248 · PMCID PMC13167770 · OpenAlex W7160383207
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Categories: drosophila (organism), cellular / molecular (subfield)
Methods: Preprocessing, Evoked potentials, Machine learning, fMRI & imaging
Keywords: patterning, 3D cell shapes, Notch signaling, development, mathematical modeling
MeSH: Body Patterning*, Epithelial Cells*, Signal Transduction*, Animals, Cell Communication, Drosophila, Drosophila melanogaster, Drosophila Proteins, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Models, Biological, Receptors, Notch, Wings, Animal (* major topic)
Topic: Developmental Biology and Gene Regulation (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Leverhulme Trust (RPG-2022-028); European Molecular Biology Organization (ALTF 786-2020); UKRI | MRC | Medical Research Council Laboratory of Molecular Biology (LMB) (MC_UP_1201/27); Medical Research Council (MR/W027437/1); UKRI | Medical Research Council (MR/W027437/1)
Citations: cited by 2 papers (Europe PMC); 35 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repositories

Its files are read in the Code ↔ Paper reader above.

Zenodo 19385318

License: CC-BY-4.0
State: the link answers, verified on 28 September 2026
Evidence: files inventoried
Size: 2 files
Software Heritage: not checked
Found in: “Data, Materials, and Software Availability”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers (HTTP 200)
  • 28 September 2026: the link answers (HTTP 200)
1 file

fberkemeier/MultiLayer-NotchDelta

License: MIT
State: the link answers, verified on 28 September 2026
Evidence: files inventoried
Commit: 3b57131a149ff4723dbdf43e401c0ee2cbb141af, 8 May 2026
Languages: Python (3), Jupyter (1)
Size: 38 files, 4 scripts
Software Heritage: not archived
Found in: “Data, Materials, and Software Availability”
Holds: README, license file, environment (requirements.txt, docs/requirements.txt), documentation, 1 notebook
Not found: CITATION.cff, tests, continuous integration
Tools: Matplotlib (1 file), NumPy (1 file), pandas (1 file), SciPy (1 file)
Availability: 1 check, the latest on 28 September 2026: the link answers
  • 28 September 2026: the link answers
6 files

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 4 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1073/pnas.2522727123.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 5 keywords, 13 MeSH terms, 5 funders, 32 references.

Cite

This paper

Paci, G., Berkemeier, F., Baum, B., Page, K. M., & Mao, Y. (2026). 3D epithelial cell topology tunes signaling range to promote precise patterning. Proceedings of the National Academy of Sciences of the United States of America, 123(19), e2522727123. https://doi.org/10.1073/pnas.2522727123

BibTeX

@article{paci20263d,
author = {Paci, Giulia and Berkemeier, Francisco and Baum, Buzz and Page, Karen M and Mao, Yanlan},
title = {{3D epithelial cell topology tunes signaling range to promote precise patterning}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = may,
volume = {123},
number = {19},
pages = {e2522727123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2522727123},
url = {https://doi.org/10.1073/pnas.2522727123},
pmid = {42090248},
pmcid = {PMC13167770}
}

RIS

TY - JOUR
AU - Paci, Giulia
AU - Berkemeier, Francisco
AU - Baum, Buzz
AU - Page, Karen M
AU - Mao, Yanlan
TI - 3D epithelial cell topology tunes signaling range to promote precise patterning
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/05/06
VL - 123
IS - 19
SP - e2522727123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2522727123
UR - https://doi.org/10.1073/pnas.2522727123
LA - en
ER -

CSL-JSON

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"id": "10.1073/pnas.2522727123",
"type": "article-journal",
"title": "3D epithelial cell topology tunes signaling range to promote precise patterning",
"container-title": "Proceedings of the National Academy of Sciences of the United States of America",
"author": [
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"family": "Paci",
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"given": "Francisco"
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{
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"container-title-short": "Proc Natl Acad Sci U S A",
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"issue": "19",
"page": "e2522727123",
"DOI": "10.1073/pnas.2522727123",
"PMID": "42090248",
"PMCID": "PMC13167770",
"ISSN": "0027-8424",
"publisher": "National Academy of Sciences",
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"language": "en",
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"date-parts": [
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}
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