OSCR

Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions.

Overview

Authors: Kelly N Barko1,2, Micah A Shelton1, Dawson R Kropp3, Thien Quy Pham4, Jennifer R Rainville3, Xiangning Xue4, George C Tseng4, Georgia E Hodes3, Marianne L Seney1,2
  1. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
  2. Center for Neuroscience at University of Pittsburgh, Pittsburgh, PA 15261
  3. School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061
  4. Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261
Institutions: University of Pittsburgh (United States); Virginia Tech (United States)
Dates: received 7 November 2025; accepted 24 April 2026; published online 26 May 2026; in print 2 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2531920123 · PMID 42189975 · PMCID PMC13229181 · OpenAlex W7162400637
Open access: hybrid, a free copy (OpenAlex)
Categories: genetics / omics (modality), mouse (organism), depression (population), systems (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Preprocessing, Connectivity
Keywords: sex differences, transcriptomics, stress susceptibility, corticolimbic
MeSH: Major Depressive Disorder*, Prefrontal Cortex*, Sex Chromosomes*, Stress, Psychological*, Animals, Brain, Female, Male, Mice, Mice, Inbred C57BL, Nucleus Accumbens, Sex Characteristics (* major topic)
Topic: Stress Responses and Cortisol (Behavioral Neuroscience, Neuroscience), according to OpenAlex
Funding: Brain and Behavior Research Foundation (BBRF) (N/A); HHS | NIH | National Institute of Mental Health (NIMH) (MH120066)
Citations: cited by 1 paper (Europe PMC); 80 references in the paper
Research resources: RRID:SCR_023116

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1073/pnas.2531920123.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 4 keywords, 12 MeSH terms, 2 funders, 78 references, 1 RRID.

Cite

This paper

Barko, K. N., Shelton, M. A., Kropp, D. R., Pham, T. Q., Rainville, J. R., Xue, X., Tseng, G. C., Hodes, G. E., & Seney, M. L. (2026). Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions. Proceedings of the National Academy of Sciences of the United States of America, 123(22), e2531920123. https://doi.org/10.1073/pnas.2531920123

BibTeX

@article{barko2026impact,
author = {Barko, Kelly N and Shelton, Micah A and Kropp, Dawson R and Pham, Thien Quy and Rainville, Jennifer R and Xue, Xiangning and Tseng, George C and Hodes, Georgia E and Seney, Marianne L},
title = {{Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = may,
volume = {123},
number = {22},
pages = {e2531920123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2531920123},
url = {https://doi.org/10.1073/pnas.2531920123},
pmid = {42189975},
pmcid = {PMC13229181}
}

RIS

TY - JOUR
AU - Barko, Kelly N
AU - Shelton, Micah A
AU - Kropp, Dawson R
AU - Pham, Thien Quy
AU - Rainville, Jennifer R
AU - Xue, Xiangning
AU - Tseng, George C
AU - Hodes, Georgia E
AU - Seney, Marianne L
TI - Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/05/26
VL - 123
IS - 22
SP - e2531920123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2531920123
UR - https://doi.org/10.1073/pnas.2531920123
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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