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Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence.

Overview

Authors: Allison H. Kao1,2, Biswa P. Mishra3, Mitchell Sorbello4, Wenbin Zhang5, Qinyi Zhou5, Yuefeng Jiang6, Veronika Masic3, Paige Harten3, Weixi Gu4, Jian Yuan Yang7, A. Joseph Bloom2,8, Robi D. Mitra2, Zhe Zhang6, Yong Juan Zhao7, Giuseppe Orsomando9, Xiaodong Wang5, Jeffrey Milbrandt2,8, Bostjan Kobe4, Thomas Ve3, Aaron DiAntonio1,8
ORCID iDs: Biswa P. Mishra, Robi D. Mitra, Zhe Zhang, Yong Juan Zhao, Xiaodong Wang, Jeffrey Milbrandt, Bostjan Kobe, Aaron DiAntonio
  1. Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110
  2. Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110
  3. Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD 4222, Australia
  4. School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD 4072, Australia
  5. National Institute of Biological Sciences, Beijing 102206, China
  6. State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
  7. Division of Biomedical Health Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China
  8. Needleman Center for Neurometabolism and Axonal Therapeutics, St. Louis, MO 63110
  9. Department of Clinical Sciences, Section of Biochemistry, Polytechnic University of Marche, Ancona 60131, Italy
Institutions: Washington University in St. Louis (United States); Griffith University (Australia); Institute for Molecular Bioscience (Australia); National Institute of Biological Sciences, Beijing (China); Center for Life Sciences (China); Chinese University of Hong Kong, Shenzhen (China); Marche Polytechnic University (Italy)
Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 37, article e2620112123
Dates: received 14 June 2026; accepted 5 August 2026; published online 11 September 2026; in print 15 September 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2620112123 · PMID 42726653 · PMCID PMC13578336 · OpenAlex W7212273714
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), cellular / molecular (subfield)
Methods: Evoked potentials
Keywords: SARM1, NADase, axon degeneration, DNA, neurodegeneration
MeSH: Armadillo Domain Proteins*, Cytoskeletal Proteins*, DNA*, Animals, Humans, Mice, NAD, Neurons (* major topic)
Journal subjects: Biological Sciences, Biochemistry
Topic: Sirtuins and Resveratrol in Medicine (Geriatrics and Gerontology, Medicine), according to OpenAlex
Funding: National Institutes of Health (NS087632); National Health and Medical Research Council (1196590 and 2042089 and 2025931); Ministry of Science and Technology of China (Insititutional); Beijing Municipal Natural Science Foundation (Institutional); National Natural Science Foundation of China (32470755 to Y.J.Z, 32471252)
Citations: cited by 1 paper (Europe PMC); 50 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1073/pnas.2620112123.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 5 keywords, 8 MeSH terms, 5 funders, 50 references.

Cite

This paper

Kao, A. H., Mishra, B. P., Sorbello, M., Zhang, W., Zhou, Q., Jiang, Y., Masic, V., Harten, P., Gu, W., Yang, J. Y., Bloom, A. J., Mitra, R. D., Zhang, Z., Zhao, Y. J., Orsomando, G., Wang, X., Milbrandt, J., Kobe, B., Ve, T., & DiAntonio, A. (2026). Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence. Proceedings of the National Academy of Sciences of the United States of America, 123(37), e2620112123. https://doi.org/10.1073/pnas.2620112123

BibTeX

@article{kao2026direct,
author = {Kao, Allison H. and Mishra, Biswa P. and Sorbello, Mitchell and Zhang, Wenbin and Zhou, Qinyi and Jiang, Yuefeng and Masic, Veronika and Harten, Paige and Gu, Weixi and Yang, Jian Yuan and Bloom, A. Joseph and Mitra, Robi D. and Zhang, Zhe and Zhao, Yong Juan and Orsomando, Giuseppe and Wang, Xiaodong and Milbrandt, Jeffrey and Kobe, Bostjan and Ve, Thomas and DiAntonio, Aaron},
title = {{Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = sep,
volume = {123},
number = {37},
pages = {e2620112123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2620112123},
url = {https://doi.org/10.1073/pnas.2620112123},
pmid = {42726653},
pmcid = {PMC13578336}
}

RIS

TY - JOUR
AU - Kao, Allison H.
AU - Mishra, Biswa P.
AU - Sorbello, Mitchell
AU - Zhang, Wenbin
AU - Zhou, Qinyi
AU - Jiang, Yuefeng
AU - Masic, Veronika
AU - Harten, Paige
AU - Gu, Weixi
AU - Yang, Jian Yuan
AU - Bloom, A. Joseph
AU - Mitra, Robi D.
AU - Zhang, Zhe
AU - Zhao, Yong Juan
AU - Orsomando, Giuseppe
AU - Wang, Xiaodong
AU - Milbrandt, Jeffrey
AU - Kobe, Bostjan
AU - Ve, Thomas
AU - DiAntonio, Aaron
TI - Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/09/11
VL - 123
IS - 37
SP - e2620112123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2620112123
UR - https://doi.org/10.1073/pnas.2620112123
LA - en
ER -

CSL-JSON

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