Incidence of silent cerebral lesions during pulsed field ablation for paroxysmal atrial fibrillation.
Overview
- Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
- Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Abstract
Background: Radiofrequency catheter ablation (RFCA) is a first-line treatment for paroxysmal atrial fibrillation (PAF). Complications such as silent cerebral lesion (SCL) may occur during ablation. Pulsed field ablation (PFA) is a non-thermal method thatablates cardiac tissue via irreversible electroporation. Limited studies have reported the incidence of SCL during PFA, with highly variable results. However, randomized controlled trials (RCTs) remain scarce. The objective of this study was to compare perioperative SCL incidence between PFA and RFCA, and to identify risk factors for SCL during PFA.
Methods: In this prospective pilot RCT (ChiCTR2400088774), 62 patients with PAF were randomized 1:1 to undergo PFA or RFCA. Cerebral MRI (3.0 T) was performed preoperatively and 24–48h postoperatively. SCL was defined as a new acute brain lesion on MRI without neurological deficits. Baseline and surgical data of the patients were collected.
Results: SCL was detected post-procedure in 6.45% (2/
Conclusions: SCL incidence was 12.90% in the PFA group versus 6.45% in the RFCA group. While no statistically significant difference was detected between two groups, the numerically higher rate in the PFA group warrants larger studies to evaluate cerebral safety associated with PFA.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Data
Datasets cited
- figshare:31457454, at figshare; found in DataCite
Data availability statement
The original contributions presented in this study are included in the article supplementary material, which includes all tables (Tables 1–5). Further inquiries can be directed to the corresponding author.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 4 keywords, 13 MeSH terms, 1 funder, 42 references.
Cite
This paper
Ding, P., Chen, W., Shen, J., Qiu, B., Hu, X., Xie, L., Liu, Z., Li, F., Ge, L., Wei, H., Zhang, B., Zhang, Q., Wang, Z., Chen, M., Li, C., & Zhang, C. (2026). Incidence of silent cerebral lesions during pulsed field ablation for paroxysmal atrial fibrillation. Annals of medicine, 58(1), 2634472. https://
BibTeX
@article{ding2026inciden
author = {Ding, Peiqi and Chen, Wensu and Shen, Jianfan and Qiu, Bowen and Hu, Xiaoqin and Xie, Lixiang and Liu, Zhongxiao and Li, Fei and Ge, Liqi and Wei, Hui and Zhang, Baixiang and Zhang, Quan and Wang, Zhirong and Chen, Minglong and Li, Chengzong and Zhang, Chaoqun},
title = {{Incidence of silent cerebral lesions during pulsed field ablation for paroxysmal atrial fibrillation}},
journal = {Annals of medicine},
year = {2026},
month = mar,
volume = {58},
number = {1},
pages = {2634472},
publisher = {Taylor \& Francis},
issn = {0785-3890},
doi = {10.1080/
url = {https://
pmid = {41774050},
pmcid = {PMC12958377}
}
RIS
TY - JOUR
AU - Ding, Peiqi
AU - Chen, Wensu
AU - Shen, Jianfan
AU - Qiu, Bowen
AU - Hu, Xiaoqin
AU - Xie, Lixiang
AU - Liu, Zhongxiao
AU - Li, Fei
AU - Ge, Liqi
AU - Wei, Hui
AU - Zhang, Baixiang
AU - Zhang, Quan
AU - Wang, Zhirong
AU - Chen, Minglong
AU - Li, Chengzong
AU - Zhang, Chaoqun
TI - Incidence of silent cerebral lesions during pulsed field ablation for paroxysmal atrial fibrillation
T2 - Annals of medicine
J2 - Ann Med
PY - 2026
DA - 2026/
VL - 58
IS - 1
SP - 2634472
SN - 0785-3890
PB - Taylor & Francis
DO - 10.1080/
UR - https://
LA - en
ER -
CSL-JSON
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