Intracranial biomarkers for anterior thalamic deep brain stimulation in epilepsy: a long-term observational study.
Overview
- Department of Health Science and Technology, ETH Zurich, Zurich 8092, Switzerland
- Department of Epileptology, Swiss Epilepsy Center Klinik Lengg, Zurich 8008, Switzerland
- Department of Neurosurgery, University Hospital Zurich, Zurich 8091, Switzerland
- Institute for Neuroscience, ETH Zurich, Zurich 8057, Switzerland
Abstract
Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is an established treatment for patients with drug-refractory epilepsy, yet long-term therapeutic outcomes are highly variable and challenging to predict. This variability is compounded by the delayed and gradual effects of DBS, the difficulty of consistent seizure monitoring, and the absence of physiological biomarkers to inform treatment. In this study, we analysed longitudinal intracranial recordings over an observational period of 4 years from a cohort of 22 patients with ANT DBS. Our primary goal is the identification of neurophysiological signatures that could predict and track clinical DBS response.
Our results show that DBS responders and non-responders exhibit distinct ANT spectral trajectories over time, with responders showing a progressive increase in higher frequencies (β1 and γ) and decreased lower-frequency (δ and θ) activity in comparison to non-responders. Notably, these dynamic biomarkers, particularly high- to low-frequency ratios (e.g. β1/
Together, these findings propose ANT spectral dynamics in outpatient settings as a promising tool for early prediction of therapeutic efficacy and pave the way for biomarker-guided optimization of DBS therapy in epilepsy.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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According to the subjects’ consent, which did not include a provision stating that individual raw data can be made accessible, the data supporting the findings of this study are not included. The code that supports the findings of this study is available from the corresponding author, upon reasonable request.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Version 1, 4 November 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 14 MeSH terms, 1 funder, 1 references.
Cite
This paper
Aiello, G., Elshahabi, A., Stieglitz, L., Belvedere, A., Dubcek, T., Polania, R., & Imbach, L. (2026). Intracranial biomarkers for anterior thalamic deep brain stimulation in epilepsy: a long-term observational study. Brain : a journal of neurology, 149(11), 3806-3820. https://
BibTeX
@article{aiello2026intra
author = {Aiello, Giovanna and Elshahabi, Adham and Stieglitz, Lennart and Belvedere, Anina and Dubcek, Tena and Polania, Rafael and Imbach, Lukas},
title = {{Intracranial biomarkers for anterior thalamic deep brain stimulation in epilepsy: a long-term observational study}},
journal = {Brain : a journal of neurology},
year = {2026},
month = nov,
volume = {149},
number = {11},
pages = {3806--3820},
publisher = {Oxford University Press},
issn = {0006-8950},
doi = {10.1093/
url = {https://
pmid = {41934257},
pmcid = {PMC13730554}
}
RIS
TY - JOUR
AU - Aiello, Giovanna
AU - Elshahabi, Adham
AU - Stieglitz, Lennart
AU - Belvedere, Anina
AU - Dubcek, Tena
AU - Polania, Rafael
AU - Imbach, Lukas
TI - Intracranial biomarkers for anterior thalamic deep brain stimulation in epilepsy: a long-term observational study
T2 - Brain : a journal of neurology
J2 - Brain
PY - 2026
DA - 2026/
VL - 149
IS - 11
SP - 3806
EP - 3820
SN - 0006-8950
PB - Oxford University Press
DO - 10.1093/
UR - https://
LA - en
ER -
CSL-JSON
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