Conservation of Human IgSF Proteins Throughout Eukaryotic Evolution.
The 2 matches
- [1] § Results › CD58 ↔ conservation-IgSFSize.py, lines 203–273 · score 0.88 · egg laying mammals, placental mammals, Dermoptera, Euarchontoglires, Eutheria, Lagomorpha
- [2] § Materials and Methods › Clustering of IgSF ↔ otherScripts/brotherhoodMethod.py, lines 80–91 · score 0.64 · squareform, weighted, correlation, linkage, metric, cut
Paper
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The authors' code
Python · 532 lines · 18 KB · no license · 1 match
conservation-IgSFSize.py at commit af03288, no license · at the source
Overview
- Department of Systems & Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
- Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Abstract
The human immunoglobulin superfamily (IgSF) encompasses hundreds of proteins involved in cell–cell adhesion, neural connectivity, junctional organization, and immune regulation, with many serving as key checkpoint proteins. To elucidate the evolutionary history of human IgSF members, we systematically analyzed all available eukaryotic reference genomes to determine when each IgSF subfamily first appeared. The human IgSF was partitioned into six major evolutionary timeframes: Metazoa, Vertebrata, Gnathostomata, Tetrapoda, Amniota, and Mammalia. Although proteins were grouped solely by their conservation across eukaryotes, their biological functions clustered naturally, reflecting how new physiological systems create selective pressures that drive the appearance, retention, and diversification of protein architectures suited to those functions. Conservation and functional analyses indicate that human IgSF members arising in tetrapods and amniotes primary regulate the strength and duration of immune responses and form many of the critical components of the immune synapse, while IgSF genes that appear first in mammals have evolved to fine-tune immune activation thresholds to support maternal–fetal tolerance. Case studies are provided to illustrate three key evolutionary themes: (i) highly conserved yet catalytically inactive proteins retain essential regulatory functions, (ii) functional convergence among evolutionarily distinct IgSF families, and (iii) compensatory evolution within adaptive immunity following a lineage-specific loss of an IgSF member. Together, these findings establish an evolutionary framework for organizing the human IgSF by both ancestry and function, providing a foundation for assessing IgSF importance. Notably, this study facilitates the identification of conserved but understudied proteins that emerged alongside the development of the adaptive immune system, highlighting them as promising candidates for future experimental investigation.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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StevenGrudman/IgSF-Conservation
af032888ebd9488e70430d119a5f9e2cb71bdd7c, 25 November 2025Availability: 1 check, the latest on 27 September 2026: the link answers
- 27 September 2026: the link answers
7 files, not copied: shown from their source
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- conservation-IgSFSize.py
— Python, 532 lines, 1 match, shown from its source - otherScripts/
assignOrthologs1.py — Python, 447 lines, shown from its source - otherScripts/
blastIgSF.py — Python, 24 lines, shown from its source - otherScripts/
brotherhoodMethod.py — Python, 102 lines, 1 match, shown from its source - otherScripts/
submit_orth_human_redo.s — Shell, 14 lines, shown from its sourceh - otherScripts/
submit_singleJob.sh — Shell, 9 lines, shown from its source - README.md — Text, 27 lines, shown from its source
The paper's code and data availability statement is in the Data section.
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The data underlying this article can be found in the online Supplementary material. In addition, all data and a program that can facilitate browsing results are publicly accessible at https://
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 2 authors, 4 keywords, 6 MeSH terms, 1 funder, 105 references.
Cite
This paper
Grudman, S., & Fiser, A. (2026). Conservation of Human IgSF Proteins Throughout Eukaryotic Evolution. Genome biology and evolution, 18(6), evag133. https://
BibTeX
@article{grudman2026cons
author = {Grudman, Steven and Fiser, Andras},
title = {{Conservation of Human IgSF Proteins Throughout Eukaryotic Evolution}},
journal = {Genome biology and evolution},
year = {2026},
month = jun,
volume = {18},
number = {6},
pages = {evag133},
publisher = {Oxford University Press},
issn = {1759-6653},
doi = {10.1093/
url = {https://
pmid = {42230317},
pmcid = {PMC13262535}
}
RIS
TY - JOUR
AU - Grudman, Steven
AU - Fiser, Andras
TI - Conservation of Human IgSF Proteins Throughout Eukaryotic Evolution
T2 - Genome biology and evolution
J2 - Genome Biol Evol
PY - 2026
DA - 2026/
VL - 18
IS - 6
SP - evag133
SN - 1759-6653
PB - Oxford University Press
DO - 10.1093/
UR - https://
LA - en
ER -
CSL-JSON
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