White matter functional connectome topology and its clinical correlations in adolescent major depressive disorder.
Overview
- The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, P.R. China
- Brain-Computer Interface and Brain-Inspired Intelligence Key Laboratory of Sichuan Province, Chengdu 611731, P.R. China
- Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
- Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
- Department of Psychological and Sleep Psychosomatic Center, The Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing 402360, P.R. China
- Department of Radiology, The Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing 402360, P.R. China
Abstract
Background: Adolescence is a critical period for brain network remodeling and the onset of major depressive disorder (MDD); however, white matter (WM) functional topology in adolescent MDD remains underexplored. Given that WM functional signals reflect meaningful neural activity and are disrupted in psychiatric disorders, this study aimed to characterize WM functional connectome alterations in adolescents with MDD and examine their clinical associations.
Methods: Resting-state fMRI data were obtained from a cohort of adolescents with MDD (n = 320) and healthy controls (HCs, n = 144), as well as from an independent replication cohort. Following the construction of thresholded WM functional networks, graph-theoretical analyses were used to calculate global topological properties. Canonical correlation analysis (CCA) was used to examine associations between topology and clinical symptoms, while exploratory classification assessed their discriminative information and generalizability. Furthermore, subgroup analyses were conducted to evaluate the effects of a history of suicide attempt, non-suicidal self-injury, childhood trauma, and sex.
Results: Compared with HCs, adolescent MDD exhibited significant reductions in the clustering coefficient, characteristic path length, and local efficiency. CCA identified distinct covariation patterns: reduced global integration was linked to severe suicidal ideation and depressed mood, while impaired local segregation was associated with vegetative symptoms such as weight loss and insomnia. Subgroup analyses revealed significant sexual dimorphism, with male patients demonstrating more severe topological impairments than females. A similar pattern was observed in the independent replication cohort. The classification analysis achieved above-chance accuracy (69.6 and 60% in the two cohorts).
Conclusions: Our results reveal a topologically shifted WM functional connectome structure in adolescent MDD, providing new clues to aid in understanding the pathophysiology of its pathophysiology.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Datasets cited
- doi:10.18112/
openneuro.ds004627.v1.1. , at OpenNeuro; found in the references0 - openneuro:ds004627, at OpenNeuro; found in “Data availability”
Data availability
The data of the discovery cohort can be obtained from the corresponding author, and the replication cohort data can be found on OpenNeuro (https://
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Funding: added National Natural Science Foundation of China: 62571105, 62333003, 62473082, 82121003; University of Electronic Science and Technology of China: ZYGX2021YGLH201; Fundamental Research Funds for the Central Universities: ZYGX2022YGRH008, ZYGX2024XJ054
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 16 authors, 5 keywords, 54 references.
Cite
This paper
Chen, K., Li, X., Chen, H., He, Y., Huang, Y., Wang, W., Ran, S., Huang, Z., Qiu, K., Shu, X., Jiang, X., Long, X., Li, W., Liao, W., Zhou, X., & Li, J. (2026). White matter functional connectome topology and its clinical correlations in adolescent major depressive disorder. Psychoradiology, 6, kkag025. https://
BibTeX
@article{chen2026white,
author = {Chen, Kangjia and Li, Xuemei and Chen, Hongyi and He, Yaohui and Huang, Yang and Wang, Wenjing and Ran, Shenglan and Huang, Zhiqiang and Qiu, Kangyu and Shu, Xin and Jiang, Xiaocong and Long, Xianghua and Li, Wei and Liao, Wei and Zhou, Xinyu and Li, Jiao},
title = {{White matter functional connectome topology and its clinical correlations in adolescent major depressive disorder}},
journal = {Psychoradiology},
year = {2026},
month = jul,
volume = {6},
pages = {kkag025},
publisher = {Oxford University Press},
issn = {2634-4416},
doi = {10.1093/
url = {https://
pmid = {42518885},
pmcid = {PMC13384069}
}
RIS
TY - JOUR
AU - Chen, Kangjia
AU - Li, Xuemei
AU - Chen, Hongyi
AU - He, Yaohui
AU - Huang, Yang
AU - Wang, Wenjing
AU - Ran, Shenglan
AU - Huang, Zhiqiang
AU - Qiu, Kangyu
AU - Shu, Xin
AU - Jiang, Xiaocong
AU - Long, Xianghua
AU - Li, Wei
AU - Liao, Wei
AU - Zhou, Xinyu
AU - Li, Jiao
TI - White matter functional connectome topology and its clinical correlations in adolescent major depressive disorder
T2 - Psychoradiology
J2 - Psychoradiology
PY - 2026
DA - 2026/
VL - 6
SP - kkag025
SN - 2634-4416
PB - Oxford University Press
DO - 10.1093/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1093/
"type": "article-journal",
"title": "White matter functional connectome topology and its clinical correlations in adolescent major depressive disorder",
"container-title": "Psychoradiology",
"author": [
{
"family": "Chen",
"given": "Kangjia"
},
{
"family": "Li",
"given": "Xuemei"
},
{
"family": "Chen",
"given": "Hongyi"
},
{
"family": "He",
"given": "Yaohui"
},
{
"family": "Huang",
"given": "Yang"
},
{
"family": "Wang",
"given": "Wenjing"
},
{
"family": "Ran",
"given": "Shenglan"
},
{
"family": "Huang",
"given": "Zhiqiang"
},
{
"family": "Qiu",
"given": "Kangyu"
},
{
"family": "Shu",
"given": "Xin"
},
{
"family": "Jiang",
"given": "Xiaocong"
},
{
"family": "Long",
"given": "Xianghua"
},
{
"family": "Li",
"given": "Wei"
},
{
"family": "Liao",
"given": "Wei"
},
{
"family": "Zhou",
"given": "Xinyu"
},
{
"family": "Li",
"given": "Jiao"
}
],
"container-title-short":
"volume": "6",
"page": "kkag025",
"DOI": "10.1093/
"PMID": "42518885",
"PMCID": "PMC13384069",
"ISSN": "2634-4416",
"publisher": "Oxford University Press",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
7,
6
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1002/gps3.70014 [code]
- Correspondence between morphological similarity of the left lateral orbitofrontal cortex and neurotransmitter systems in adolescent males with autism.Journal: General psychiatryIn common: developmental, 5 references
- [2] doi:10.1038/s41398-026-04025-2 [code]
- Brain energetic landscapes shape state dysregulation in major depressive disorder: a morphological network controllability perspective.Journal: Translational psychiatryIn common: depression, author Wei Liao
- [3] doi:10.1017/s0033291726104711
- Cell-type and spatiotemporal transcriptional signatures of white matter morphometric similarity network alterations in major depressive disorder.Journal: Psychological medicineIn common: depression, 3 references
- [4] doi:10.1038/s42003-026-10237-5 [code]
- Shared subcortical-default mode morphological dysconnectivity in adolescent bipolar disorder, major depressive disorder and schizophrenia.Journal: Communications biologyIn common: depression, developmental, 2 references
- [5] doi:10.31083/ap48336
- Brain Functional Network Alterations in Adolescents With Major Depressive Disorder and Suicidal Attempt: A Resting-State fMRI Study.Journal: Alpha psychiatryIn common: depression, developmental, 2 references
- [6] doi:10.1038/s41398-026-04130-2 [code]
- White matter structure-function coupling in neonatal brain and its association with Autism-related traits in early childhood.Journal: Translational psychiatryIn common: developmental, 2 references
- [7] doi:10.1016/j.isci.2026.117012 [code]
- Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates.Journal: iScienceIn common: developmental, 3 references
- [8] doi:10.1038/s41398-026-03965-z [code]
- Disentangling individual heterogeneity reveals robust network and molecular signatures of major depressive disorder with suicidal ideation.Journal: Translational psychiatryIn common: depression, 2 references
- [9] doi:10.1093/sleep/zsag030 [code]
- Divergent disruption of brain networks following total and chronic sleep loss: a longitudinal fMRI study.Journal: SleepIn common: 3 references
- [10] doi:10.1007/s12311-026-02042-x
- The Cerebellar Connectome.Journal: Cerebellum (London, England)In common: 3 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.