Genome-wide association studies identify 77 loci for suicidality and provide novel biological insights

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sarahcolbert/PGC_SUI_PRS

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OverviewAuthors: Sarah MC Colbert, Maria Koromina, Alexander S Hatoum, Mallory Stephenson, Alexis C Edwards, Emma C Johnson, Xuejun Qin, Andrey A Shabalin, Lucas T Ito, Kevin S O'Connell, Arvid Harder, Jens Hjerling-Leffler, Min Ji Kim, Ikuo Otsuka, Laura Vilar-Ribó, Arpana Agrawal, Martin Alda, Lars Alfredsson, Fazil Aliev, Till FM Andlauerand 227 other authorsCelso Arango, Arnoud Arntz, Swapnil Awasthi, Olatunde O Ayinde, Silviu-Alin Bacanu, Peter B Barr, Claiton HD Bau, Bernhard T Baune, Jean C Beckham, Cosmin A Bejan, Sintia Belangero, Klaus Berger, Joanna M Biernacka, Ryan Bogdan, Dorret I Boomsma, Anders D Børglum, Kyle J Bourassa, David L Braff, Alice Braun, Rodrigo A Bressan, Tanja M Brueckl, Monika Budde, Brenda Cabrera-Mendoza, Bernardo Carpiniello, Zuriel Ceja, Jorge A Cervilla, Chiao-Erh Chang, Boris Chaumette, Myeong Jae Cheon, Sven Cichon, Jonathan RI Coleman, Hilary Coon, William E Copeland, Darina Czamara, Nina Dalkner, Udo Dannlowski, Friederike S David, Ditte Demontis, Arianna Di Florio, Carmen C Diaconu, Danielle M Dick, Dimitris Dikeos, Srdjan Djurovic, Howard J Edenberg, Annette Erlangsen, Sebastian Euler, Peter Falkai, Giuseppe Fanelli, Frederike T Fellendorf, Panagiotis Ferentinos, Fernando Fernandez-Aranda, Andreas J Forstner, Oleksandr Frei, Gabriel R Fries, Janice M Fullerton, Marie E Gaine, Hanga C Galfalvy, Marco Galimberti, Judith Garcia-Aymerich, Melanie E Garrett, Micha Gawlik, Joel Gelernter, Katherine Gordon-Smith, Aaron J Gorelik, Philip Gorwood, Hans J Grabe, Melissa J Green, Maria Grigoroiu-Serbanescu, Priya Gupta, Blanca Gutiérrez, Jose Guzman-Parra, Seonggyun Han, Marit Haram, Elizabeth R Hauser, Urs Heilbronner, Sabine C Herpertz, Jesús Herrera-Imbroda, Victor M Hesselbrock, Akitoyo Hishimoto, Bharath Holla, Anastasia Izotova, Yoonjeong Jang, Susana Jimenez-Murcia, Lisa A Jones, Lina Jonsson, Joo Eun Kang, Joon Ho Kang, Pamela K Keel, Jaeyoung Kim, Dongjun Kim, Tilo Kircher, George Kirov, Julia Kraft, John Kramer, Henry R Kranzler, Po-Hsiu Kuo, Siim Kurvits, Dongbing Lai, Marilyn T Lake, Mikael Landén, Séverine Lannoy, Matthew H Law, Byung-Chul Lee, Young Kee Lee, Kelli Lehto, Daniel F Levey, Cathryn M Lewis, Qingqin S Li, Calwing Liao, Penelope A Lind, Christine Lochner, Adriana Lori, Hermine HM Maes, Jayant Mahadevan, Mirko Manchia, Becky Mars, Nicholas G Martin, Lourdes Martorell, Andrew M McIntosh, Shelley F McMain, Andrew McQuillin, Sarah E Medland, Philip B Mitchell, Esther Molina, Eric T Monson, Mary S Mufford, Gerard Muntané, Richard Musil, Woojae Myung, Ana Iulia Neagu, Trine T Nielsen, Markus M Nöthen, Yaira Z Nunez, John I Nurnberger, Satoshi Okazaki, Catherine M Olsen, Roel A Ophoff, Michael J Owen, Pedro M Pan, Sergi Papiol, Juan C Pascual, George P Patrinos, Joanna M Pawlak, Brenda WJH Penninx, Ana M Pérez-Gutiérrez, Nader Perroud, Roseann E Peterson, Claudia Pisanu, Giorgio Pistis, Bernice Porjesz, Danielle Posthuma, Abigail Powers, Martin Preisig, Meera Purushottam, Andreas Reif, Eva Z Reininghaus, Miguel E Rentería, Stephan Ripke, Michael A Ripperger, Margarita Rivera, Emily K Roberts, Gloria Roberts, Linn Rødevand, Stefan Roepke, Diego L Rovaris, Giovanni A Salum, Alan R Sanders, Marcos L Santoro, Chelsea Sawyers, Stephen W Scherer, Claudia Schilling, Christian Schmahl, Peter R Schofield, Thomas G Schulze, Laura J Scott, Alessandro Serretti, Alexey Shadrin, Toshiyuki Shirai, Olav B Smeland, Jordan W Smoller, Marcus Sokolowski, Edmund J Sonuga-Barke, Alessio Squassina, Anna Starnawska, Nils Eiel Steen, Dan J Stein, Frederike Stein, Murray B Stein, Fabian Streit, Reeteka Sud, Patrick F Sullivan, Chikashi Terao, Claudio Toma, Leonardo Tondo, Gustavo Turecki, Rudolf Uher, Robert J Ursano, Sandra Van der Auwera, Marquis P Vawter, Alja Videtic Paska, Elisabet Vilella, John B Vincent, Biju Viswanath, Vladimir Vladimirov, Danuta E Wasserman, Thomas W Weickert, David C Whiteman, Virginia L Willour, Erik D Wiström, Stephanie H Witt, Hong-Hee Won, Robyn E Wootton, Clement C Zai, Jian Zhang, Lea Zillich, CVEDA and MGL, Genoplan Research Team, International Borderline Genomics Consortium, Ole A Andreassen, Abraham A Palmer, Sandra Sanchez-Roige, J John Mann, Nathan A Kimbrel, Allison E Ashley-Koch, Douglas M Ruderfer, Anna R Docherty, Niamh Mullins
Journal: medRxiv (preprint)
Published: 23 October 2025
Type: Preprint
Status: code verified (how the code is found and verified)
DOI: 10.1101/2025.10.22.25338076
License: CC BY-NC-ND
Institutions: Icahn School of Medicine at Mount Sinai (United States), Taylor Family Institute for Innovative Psychiatric Research (United States), Virginia Commonwealth University (United States), Durham VA Health Care System (United States), University of Utah (United States), Universidade Federal de São Paulo (Brazil), University of Oslo (Norway), Oslo University Hospital (Norway), Karolinska Institutet (Sweden), Columbia University (United States), Kobe University (Japan), RIKEN Center for Integrative Medical Sciences (Japan), University of California San Diego (United States), Dalhousie University (Canada), National Institute of Mental Health (Czechia), Rutgers, The State University of New Jersey (United States), Technical University of Munich (Germany), Hospital Universitario La Paz (Spain), Universidad Autónoma de Madrid (Spain), Centro de Investigación Biomédica en Red de Salud Mental (Spain), University of Amsterdam (Netherlands), Charité – Universitätsmedizin Berlin (Germany), Stanley Center for Psychiatric Research (United States), Broad Institute (United States), University of Ibadan (Nigeria), SUNY Downstate Health Sciences University (United States), Universidade Federal do Rio Grande do Sul (Brazil), University of Münster (Germany), The University of Melbourne (Australia), Mental Illness Research, Education and Clinical Centers (United States), Duke University (United States), Vanderbilt University Medical Center (United States), Mayo Clinic (United States), Washington University in St. Louis (United States), Vrije Universiteit Amsterdam (Netherlands), Aarhus University (Denmark), Durham VA Medical Center (United States), Georgetown University (United States), Max Planck Institute of Psychiatry (Germany), Institut für Psychiatrische Phänomik und Genomik (Germany), Ludwig-Maximilians-Universität München (Germany), Yale University (United States), VA Connecticut Healthcare System (United States), University of Cagliari (Italy), QIMR Berghofer Medical Research Institute (Australia), The University of Queensland (Australia), Universidad de Granada (Spain), National Taiwan University (Taiwan), Institut de Psychiatrie et Neurosciences de Paris (France), Université Paris Cité (France), GHU Paris psychiatrie & neurosciences (France), McGill University (Canada), University of Basel (Switzerland), Forschungszentrum Jülich (Germany), King's College London (United Kingdom), National Institute for Health and Care Research (United Kingdom), South London and Maudsley NHS Foundation Trust (United Kingdom), University of Vermont (United States), Medical University of Graz (Austria), Bielefeld University (Germany), University of Bonn (Germany), University Hospital Bonn (Germany), Philipps University of Marburg (Germany), Cardiff University (United Kingdom), Romanian Academy (Romania), Eginition Hospital (Greece), National and Kapodistrian University of Athens (Greece), Indiana University (United States), Australian National University (Australia), University Hospital Zurich (Switzerland), LMU Klinikum (Germany), Deutsches Zentrum für Psychische Gesundheit (Germany), University of Udine (Italy), Radboud University Medical Center (Netherlands), Institut d'Investigació Biomédica de Bellvitge (Spain), Universitat de Barcelona (Spain), Instituto de Salud Carlos III (Spain), The University of Texas Health Science Center at Houston (United States), Neuroscience Research Australia (Australia), UNSW Sydney (Australia), University of Iowa (United States), Barcelona Institute for Global Health (Spain), Universitat Pompeu Fabra (Spain), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (Spain), Universitätsklinikum Würzburg (Germany), University of Worcester (United Kingdom), Inserm (France), Universitätsmedizin Greifswald (Germany), Spitalul Clinic de Psihiatrie Alexandru Obregia (Romania), Instituto de Investigación Biosanitaria de Granada (Spain), Hospital Regional Universitario de Málaga (Spain), Department of General Psychiatry, Heidelberg University, Heidelberg, Germany, UConn Health (United States), National Institute of Mental Health and Neurosciences (India), Lovisenberg Diakonale Høgskole (Norway), Norwegian Institute of Public Health (Norway), Seoul National University (South Korea), Seoul National University Bundang Hospital (South Korea), University of Gothenburg (Sweden), Mass General Brigham (United States), Florida State University (United States), Sungkyunkwan University (South Korea), Samsung Medical Center (South Korea), University of Pennsylvania (United States), University of Tartu (Estonia), University of Cape Town (South Africa), South African Medical Research Council (South Africa), Queensland University of Technology (Australia), Janssen Research & Development (United States) (United States), Massachusetts General Hospital (United States), Stellenbosch University (South Africa), American Cancer Society (United States), VCU Massey Comprehensive Cancer Center (United States), University of Bristol (United Kingdom), University Hospitals Bristol and Weston NHS Foundation Trust (United Kingdom), Institut de Recerca Biomèdica Catalunya Sud (Spain), Universitat Rovira i Virgili (Spain), University of Edinburgh (United Kingdom), Centre for Addiction and Mental Health (Canada), University of Toronto (Canada), University College London (United Kingdom), University of the Witwatersrand (South Africa), Institut de Biologia Evolutiva (Spain), Consejo Superior de Investigaciones Científicas (Spain), Barcelona Biomedical Research Park (Spain), Carol Davila University of Medicine and Pharmacy (Romania), Indiana University School of Medicine (United States), University of California, Los Angeles (United States), University of Patras (Greece), United Arab Emirates University (United Arab Emirates), Erasmus MC (Netherlands), Pasteur Hellenic Institute (Greece), Poznan University of Medical Sciences (Poland), Amsterdam University Medical Centers (Netherlands), University of Geneva (Switzerland), Centre Hospitalier Universitaire Vaudois (Switzerland), University of Lausanne (Switzerland), Emory University (United States), University Hospital Frankfurt (Germany), Goethe University Frankfurt (Germany), Fraunhofer Institute for Translational Medicine and Pharmacology (Germany), Universidade de São Paulo (Brazil), Child Mind Institute (United States), University of Chicago (United States), Hospital for Sick Children (Canada), Heidelberg University (Germany), Central Institute of Mental Health (Germany), SUNY Upstate Medical University (United States), Johns Hopkins University (United States), University of Michigan (United States), Università degli Studi di Enna Kore (Italy), Istituti di Ricovero e Cura a Carattere Scientifico (Italy), Diakonhjemmet Hospital (Norway), Medizinische Fakultät Mannheim (Germany), University of North Carolina at Chapel Hill (United States), Shizuoka General Hospital (Japan), University of Shizuoka (Japan), Centro de Biología Molecular Severo Ochoa (Spain), Universidad Autónoma Metropolitana (Mexico), McLean Hospital (United States), Uniformed Services University of the Health Sciences (United States), University of California, Irvine (United States), University of Ljubljana (Slovenia), University of Arizona (United States), Lieber Institute for Brain Development (United States), Stockholm Health Care Services (Sweden), University Medical Center Freiburg (Germany)
Categories: genetics / omics (modality), human (organism), cellular / molecular (subfield)

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