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Who Falls After a Stroke? Evidence From a Prospective Stroke Cohort.

Code ↔ Paper

2 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 2 matches · 1 of them tie a paragraph to a whole file, not to given lines: a weak match, whose lines are not tinted
  1. [1] § Materials and Methods › Imaging ↔ ea_normalize_fsl.m, the whole file · a weak match · score 0.59 · FMRIB Software Library, SyN, FSL, ANTs, Tool, brain
  2. [2] § Materials and Methods › Data Preprocessing and Dimensionality Reduction ↔ explorers/networkmapping_explorer/ea_networkmapping.m, lines 1–74 · score 0.55 · lesion network mapping, sensitivity, redundancy, permutations, Horn, correlations

Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

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The authors' code

MATLAB · 59 lines · 2.9 KB · GPL-3.0 · 1 match

  1. function varargout=ea_normalize_fsl(options)
  2. % This is a function that normalizes both a copy of transversal and coronal
  3. % images into MNI-space. The goal was to make the procedure both robust and
  4. % automatic, but still, it must be said that normalization results should
  5. % be taken with much care because all reconstruction results heavily depend
  6. % on these results. Normalization of DBS-MR-images is especially
  7. % problematic since usually, the field of view doesn't cover the whole
  8. % brain (to reduce SAR-levels during acquisition) and since electrode
  9. % artifacts can impair the normalization process. Therefore, normalization
  10. % might be best archieved with other tools that have specialized on
  11. % normalization of such image data.
  12. %
  13. % The procedure used here uses the ANTs Syn approach to map a patient's
  14. % brain to MNI space directly.
  15. % __________________________________________________________________________________
  16. % Copyright (C) 2015 Charite University Medicine Berlin, Movement Disorders Unit
  17. % Andreas Horn
  18. if ischar(options) % return name of method.
  19. varargout{1}='FNIRT (Andersson 2010)';
  20. varargout{2}=1; % dummy output
  21. varargout{3}=1; % hassettings.
  22. varargout{4}=0; % is multispectral
  23. return
  24. end
  25. % FSL FNIRT nonlinear registration
  26. ea_fnirt([ea_space, options.primarytemplate, '.nii'],...
  27. options.subj.coreg.anat.preop.(options.subj.AnchorModality),...
  28. options.subj.norm.anat.preop.(options.subj.AnchorModality));
  29. % Clean up FNIRT log file
  30. logFileBase = ea_niifileparts(options.subj.coreg.anat.preop.(options.subj.AnchorModality));
  31. ea_delete([logFileBase, '_to_*.log']);
  32. % Move transformation file
  33. transformBase = ea_niifileparts(options.subj.norm.anat.preop.(options.subj.AnchorModality));
  34. transform = dir([transformBase, 'WarpField*']);
  35. ext = regexp(transform(end).name, '(?<=WarpField)\.nii(\.gz)?$', 'match', 'once');
  36. movefile([transformBase, 'WarpField', ext], [options.subj.norm.transform.forwardBaseName, 'fnirt', ext]);
  37. movefile([transformBase, 'InverseWarpField', ext], [options.subj.norm.transform.inverseBaseName, 'fnirt', ext]);
  38. % Apply registration
  39. ea_apply_normalization(options)
  40. %% add methods dump:
  41. [scit, lcit] = ea_getspacedefcit;
  42. cits = {
  43. 'Andersson JLR, Jenkinson M, Smith S (2010) Non-linear registration, aka spatial normalisation. FMRIB technical report TR07JA2'
  44. 'Woolrich MW, Jbabdi S, Patenaude B, Chappell M, Makni S, Behrens T, Beckmann C, Jenkinson M, Smith SM (2009) Bayesian analysis of neuroimaging data in FSL. NeuroImage, 45:S173-86'
  45. };
  46. if ~isempty(lcit)
  47. cits = [cits;{lcit}];
  48. end
  49. ea_methods(options,['Pre- (and post-) operative acquisitions were spatially normalized into ',ea_getspace,' space ',scit,' based on the preoperative acquisition (',options.subj.AnchorModality,') using the'...
  50. ' FNIRT approach as implemented in the FMRIB Software Library (Andersson 2010; Woolrich 2009 https://fsl.fmrib.ox.ac.uk/).'],cits);

ea_normalize_fsl.m at commit 5b1008d, under GPL-3.0 · at the source

Overview

Authors: Anna Kufner1,2, Yunyou Tang1,2, Uchralt Temuulen1,2, Ghadir Abbas3, Torsten Rackoll1,4,5, Ulrike Grittner1,6, Daniel Kroneberg1, Benedikt Weigl3, Andrea A Kühn1,4,7,8, Martin Reich3, Alexander H Nave1,2,4,9, Matthias Endres1,2,7,8,9
  1. Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin, Klinik Für Neurologie Mit Experimenteller Neurologie, Berlin, Germany
  2. Charité ‐ Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin, Center for Stroke Research Berlin (CSB), Berlin, Germany
  3. Department of Neurology, University Hospital and Julius‐Maximilians‐University, Würzburg, Germany
  4. Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
  5. QUEST Center for Responsible Research, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
  6. Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin, Institut für Biometrie und Klinische Epidemiologie, Berlin, Germany
  7. Partner Site Berlin, German Center for Neurodegenerative Diseases (Deutsches Zentrum Für Neurodegenerative Erkrankungen, DZNE), Berlin, Germany
  8. Partner Site Berlin, German Center for Mental Health (Deutsches Zentrum Für Psychische Gesundheit, DZPG), Berlin, Germany
  9. Partner Site Berlin, German Centre for Cardiovascular Research (Deutsches Zentrum Für Herz‐Kreislauferkrankungen, DZHK), Berlin, Germany
Journal: European journal of neurology, volume 33, issue 6, article e70678
Dates: received 15 January 2026; accepted 12 June 2026; published online 24 June 2026; in print June 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1111/ene.70678 · PMID 42340058 · PMCID PMC13292268 · OpenAlex W7165793062
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: human (organism), stroke (population), clinical / translational (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity
Keywords: falls, gait, lesion network mapping, mobility, stroke
MeSH: Accidental Falls*, Gait Disorders, Neurologic*, Stroke*, Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Prospective Studies (* major topic)
Topic: Balance, Gait, and Falls Prevention (Physical Therapy, Sports Therapy and Rehabilitation, Health Professions), according to OpenAlex
Funding: The Collaborative Research Center ReTune Transregional Collaborative Research Centre (295-424778381, B07 Project); Gemeinnützige Hertie-Stiftung (Hertie Foundation); Deutsche Forschungsgemeinschaft (EXC-2049-390688087, EXC‐2049‐390688087); Corona-Stiftung; Else Kröner-Fresenius-Stiftung; Bundesministerium für Forschung, Technologie und Raumfahrt; Berlin Institute of Health; Bundesministerium für Bildung und Forschung; Deutsches Zentrum für Herz-Kreislauferkrankungen, DZHK; NeuroCure Exzellenzcluster
Citations: not cited yet (Europe PMC); 53 references in the paper

Abstract

Background: Falls affect over 30% of stroke survivors within the first year, yet lesion‐related mobility and gait impairments underlying fall risk remain poorly understood. This study aimed to identify lesion‐derived functional networks associated with impaired mobility, gait, and fall risk in subacute stroke, and to determine whether disruption to these networks is associated with falls during the six‐month follow‐up.

Methods: We analyzed data from 94 patients with disabling subacute ischemic stroke from the prospective Baptize cohort, an imaging sub‐cohort of the multicenter PHYS‐STROKE trial. Principal component (PC) analysis reduced seven mobility‐related and four gait‐related baseline variables into two composites: PC1‐Mobility and PC1‐Gait, explaining 56% and 82% of variance, respectively. PC1‐Mobility indexed global disability, whereas PC1‐Gait reflected spatiotemporal walking capacity. Lesion network mapping (LNM) identified functional networks associated with each domain. Patient‐reported falls up to six months post‐enrollment were the primary endpoint.

Results: LNM revealed that the mobility‐related network predominantly involved cortical regions, whereas the gait‐related network was linked to subcortical and infratentorial connectivity. In binary multivariable logistic regression, network similarity scores were not associated with falls; only older age was significant (adjusted OR 1.08, 95% CI 1.02–1.16, p = 0.01). LNM of fall occurrence identified a cortical network with significant spatial overlap with the mobility‐related network (p < 0.001).

Conclusion: This exploratory, hypothesis‐generating study identified distinct functional networks for post‐stroke mobility and gait impairment. Falls may be more closely linked to disruptions in cortical networks supporting voluntary motor control and whole‐body coordination than to subcortical gait‐modulating structures, potentially informing fall risk stratification and targeted prevention.

Trial Registration: ClinicalTrials.gov identifiers: BAPTISe: NCT01954797, PHYS‐STROKE: NCT01363856

Reproduced under the paper's license (CC BY), from the paper cited above.

Repositories

Its files are read in the Code ↔ Paper reader above, with 2 matches between paragraphs and lines of code.

netstim/leaddbs

License: GPL-3.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: 5b1008d705e97fe0c8f693dece14455607f4afac, 2 March 2026
Languages: MATLAB (2362), Python (101), C++ (30), C (29), Shell (10), C/C++ (4), Java (3)
Size: 6,260 files, 2,539 scripts
Software Heritage: archived
Found in: “Data Availability Statement”
Holds: README, license file, CITATION.cff, environment (ext_libs/PaCER/docs/requirements.txt), documentation
Not found: tests, continuous integration
Tools: SPM (121 files), Statistics and Machine Learning Toolbox (84 files), Tools for NIfTI and ANALYZE image (MATLAB) (38 files), Image Processing Toolbox (36 files), NumPy (35 files), FieldTrip (24 files), h5py (12 files), SciPy (8 files), FreeSurfer (7 files), cifti-matlab (6 files), Signal Processing Toolbox (6 files), Matplotlib (6 files), Parallel Computing Toolbox (5 files), pandas (5 files), TensorFlow (4 files), Keras (3 files), Optimization Toolbox (3 files), ANTs (2 files), export_fig (2 files), GIfTI library for MATLAB (2 files), NiBabel (2 files), Psychtoolbox (2 files), CAT12 (1 file), Curve Fitting Toolbox (1 file), pydicom (1 file), seaborn (1 file)
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
2,000 files

dorianps/LESYMAP

License: Apache-2.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: f9e84486f0bb88f583f771a4c216f6d215ad8f3b, 22 May 2024
Languages: R (31), C++ (7)
Size: 226 files, 38 scripts
Software Heritage: not archived
Found in: “Data Availability Statement”
Holds: README, license file, environment (DESCRIPTION), continuous integration, documentation
Not found: CITATION.cff, tests
Tools: ANTs (1 file)
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
40 files

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 2,036 scripts, each with its path and the digest of its content;
  • 2 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Open source softwares were used for the pre‐processing and analysis of the data, including: Lead‐DBS (https://github.com/netstim/leaddbs), LESYMAP package in R version 4.2.0 (https://github.com/dorianps/LESYMAP), FSL version 6.0.6.4 (https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/) and ANTsPy (https://github.com/ANTsX/ANTsPy).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 5 keywords, 10 MeSH terms, 10 funders, 53 references.

Cite

This paper

Kufner, A., Tang, Y., Temuulen, U., Abbas, G., Rackoll, T., Grittner, U., Kroneberg, D., Weigl, B., Kühn, A. A., Reich, M., Nave, A. H., & Endres, M. (2026). Who Falls After a Stroke? Evidence From a Prospective Stroke Cohort. European journal of neurology, 33(6), e70678. https://doi.org/10.1111/ene.70678

BibTeX

@article{kufner2026who,
author = {Kufner, Anna and Tang, Yunyou and Temuulen, Uchralt and Abbas, Ghadir and Rackoll, Torsten and Grittner, Ulrike and Kroneberg, Daniel and Weigl, Benedikt and Kühn, Andrea A and Reich, Martin and Nave, Alexander H and Endres, Matthias},
title = {{Who Falls After a Stroke? Evidence From a Prospective Stroke Cohort}},
journal = {European journal of neurology},
year = {2026},
month = jun,
volume = {33},
number = {6},
pages = {e70678},
publisher = {Wiley},
issn = {1351-5101},
doi = {10.1111/ene.70678},
url = {https://doi.org/10.1111/ene.70678},
pmid = {42340058},
pmcid = {PMC13292268}
}

RIS

TY - JOUR
AU - Kufner, Anna
AU - Tang, Yunyou
AU - Temuulen, Uchralt
AU - Abbas, Ghadir
AU - Rackoll, Torsten
AU - Grittner, Ulrike
AU - Kroneberg, Daniel
AU - Weigl, Benedikt
AU - Kühn, Andrea A
AU - Reich, Martin
AU - Nave, Alexander H
AU - Endres, Matthias
TI - Who Falls After a Stroke? Evidence From a Prospective Stroke Cohort
T2 - European journal of neurology
J2 - Eur J Neurol
PY - 2026
DA - 2026/06/01
VL - 33
IS - 6
SP - e70678
SN - 1351-5101
PB - Wiley
DO - 10.1111/ene.70678
UR - https://doi.org/10.1111/ene.70678
LA - en
ER -

CSL-JSON

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