DMRTA2 Regulates Radial Glial Maintenance and Tumorigenicity of Paediatric High-Grade Glioma.
Overview
- Center for Molecular Medicine, University of Georgia, Athens, Georgia, USA
- Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
- Institute of Bioinformatics, University of Georgia, Athens, Georgia, USA
- Cellular and Molecular Bioengineering Laboratory, Graduate School of Science and Engineering, Kindai University, Osaka, Japan
Abstract
DMRTA2 is a member of the evolutionarily conserved transcription factor family involved in various developmental processes including neurogenesis. However, the roles of DMRTA2 in human development and disease are not fully characterised. Single cell RNA‐seq data analysis showed that DMRTA2 is robustly expressed in neural progenitors, in particular radial glial (RG) cells, in the human fetal brain. Knockout of the DMRTA2 gene in human embryonic stem cell (hESC)‐derived cerebral organoids led to smaller organoid size and fewer RG cells. We also found that DMRTA2 is highly and specifically expressed in diffuse hemispheric gliomas, H3G34‐mutant (DHG‐H3G34), a malignant subtype of paediatric brain tumour. Loss of DMRTA2 resulted in enhanced neuronal differentiation, fewer RG‐like glioma cells and impaired tumorigenicity, suggesting its important role in both normal brain development and the formation of malignant brain tumours.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- figshare:29497694, at figshare; found in “Data Availability Statement”
- geo:GSE34824, at NCBI GEO; found in the text, “DMRTA2 KO Resulted in Fewer RG‐Like Cells in…”
Data Availability Statement
Data were deposited in Figshare.com (DOI: 10.6084/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 12 MeSH terms, 2 funders, 29 references.
Cite
This paper
Royston, H. N., Hampton, A. B., Oliver, E. G., Jackson, J., Tella, I., Emerson, M. D., Bhagat, D., Zimmerman, G. E., Konno, D., & Funato, K. (2026). DMRTA2 Regulates Radial Glial Maintenance and Tumorigenicity of Paediatric High-Grade Glioma. Journal of cellular and molecular medicine, 30(6), e71092. https://
BibTeX
@article{royston2026dmrt
author = {Royston, Hitomi N and Hampton, Autumn B and Oliver, Elissa G and Jackson, Jayden and Tella, Ibukunoluwa and Emerson, Miriam D and Bhagat, Dhruv and Zimmerman, Grace E and Konno, Daijiro and Funato, Kosuke},
title = {{DMRTA2 Regulates Radial Glial Maintenance and Tumorigenicity of Paediatric High-Grade Glioma}},
journal = {Journal of cellular and molecular medicine},
year = {2026},
month = mar,
volume = {30},
number = {6},
pages = {e71092},
publisher = {Wiley},
issn = {1582-1838},
doi = {10.1111/
url = {https://
pmid = {41844556},
pmcid = {PMC13098098}
}
RIS
TY - JOUR
AU - Royston, Hitomi N
AU - Hampton, Autumn B
AU - Oliver, Elissa G
AU - Jackson, Jayden
AU - Tella, Ibukunoluwa
AU - Emerson, Miriam D
AU - Bhagat, Dhruv
AU - Zimmerman, Grace E
AU - Konno, Daijiro
AU - Funato, Kosuke
TI - DMRTA2 Regulates Radial Glial Maintenance and Tumorigenicity of Paediatric High-Grade Glioma
T2 - Journal of cellular and molecular medicine
J2 - J Cell Mol Med
PY - 2026
DA - 2026/
VL - 30
IS - 6
SP - e71092
SN - 1582-1838
PB - Wiley
DO - 10.1111/
UR - https://
LA - en
ER -
CSL-JSON
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