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Distinct cortical spatial representations learned along disparate visual pathways.

Code ↔ Paper

3 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 3 matches · 1 of them tie a paragraph to a whole file, not to given lines: a weak match, whose lines are not tinted
  1. [1] § METHODS › Learning egocentric cells based on visual motion › Implementing the optic flow model and static feature model ↔ functions/sparse_coding_by_LCA.m, the whole file · a weak match · score 0.69 · membrane potential, model dynamics, LCA, sparse, firing rate, threshold
  2. [2] § METHODS › Learning egocentric cells based on visual motion › Implementing the optic flow model and static feature model ↔ main_V1_RSC.m, lines 107–153 · score 0.56 · membrane potential, LCA, V1, sparse, zero, firing rate
  3. [3] § RESULTS › Firing properties of experimental and model EB cells ↔ symmetry_analyses.py, lines 463–577 · score 0.52 · radial symmetry, correlation matrices, detrended, GLM, firing rate, rotational

Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

The paper is loaded when this pane is shown.

The authors' code

MATLAB · 63 lines · 2.2 KB · no license · 1 match

  1. function [S,U,S_history, U_history] = sparse_coding_by_LCA(...
  2. X, A, lambda, thresh_type, eta, s_max, n_iter, history_flag, S_past, U_past)
  3. % Implement sparse coding using local competition algorithm, i.e. LCA (Rozzel et al. 2008)
  4. % X: input matrix where each column is one example of the input
  5. % A: the columns of A are basis vectors; the number of columns are the
  6. % number of input neurons
  7. % lambda: threshold of thresholding function
  8. % tau: time constant
  9. % n_iter: maximum number of iteration
  10. % thresh_type: thresh_type of thresholding function
  11. % history_flag: record the trajectories or not
  12. % S_past, U_past: previous firing rates and membrane potentials
  13. % s_max = 300; % Maximum of neuronal response
  14. S_history = []; % Dynamics of the firing rates; each row is the responses of all neurons for the current iteration
  15. U_history = []; % Dynamics of the membrane potentials
  16. W = A' * A - eye(size(A, 2));
  17. U_init = A' * X; % Initial membrane potentials of the neuron
  18. if exist('S_past','var') && exist('U_past','var')
  19. S = S_past;
  20. U = U_past;
  21. else
  22. U = zeros(size(U_init));
  23. S = zeros(size(U_init));
  24. end
  25. % The process of computing neuronal responses
  26. for i = 1 : n_iter
  27. % Save the history (trajectory) of model dynamics
  28. if exist('history_flag','var') && (history_flag == 1)
  29. S_history(i,:) = S(:, 1); % Record the history of the first input
  30. U_history(i,:) = U(:, 1); % Record the history of the first input
  31. end
  32. % Compute the membrane potential, U, of the neuron
  33. delta_U = eta * (U_init - U - W*S);
  34. U = U + delta_U;
  35. % Get firing rate, S, of the neuron by thresholding the membrane, U
  36. if isequal(thresh_type, 'soft')
  37. S = wthresh(U, 's', lambda);
  38. elseif isequal(thresh_type, 'hard')
  39. S = wthresh(U, 'h', lambda);
  40. elseif isequal(thresh_type,'hard-non-negative')
  41. S = max(wthresh(U, 'h', lambda), 0);
  42. elseif isequal(thresh_type, 'soft-non-negative')
  43. S = max(U - lambda, 0);
  44. elseif isequal(thresh_type, 'sigmoid')
  45. alpha = 0;% [0,1]
  46. gamma = 5;
  47. lambda = 1;
  48. S = (U - alpha*lambda) ./ (1 + exp(-gamma * (U-lambda)));
  49. else
  50. error('Not a suitable threshold type. Check thresh_type');
  51. end
  52. S = min(S, s_max);
  53. end

sparse_coding_by_LCA.m at commit 2c30bbf, no license · at the source

Overview

  1. Department of Biomedical Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia
  2. Center for Systems Neuroscience, Department of Psychological and Brain Sciences, Boston University, Boston, MA 02215, USA
  3. Graeme Clark Institute for Biomedical Engineering, University of Melbourne, Melbourne, VIC 3010, Australia
Institutions: The University of Melbourne (Australia); Boston University (United States)
Journal: Science advances, volume 12, issue 33, article eaea1037
Dates: received 26 June 2025; accepted 7 July 2026; published online 14 August 2026; in print August 2026
Type: Research article · Language: English
License: CC BY-NC
Identifiers: DOI 10.1126/sciadv.aea1037 · PMID 42600021 · PMCID PMC13475576 · OpenAlex W4403361334
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: human (organism), systems (subfield)
Methods: Statistics, Machine learning, Preprocessing, fMRI & imaging, Single-unit activity, calcium imaging, Connectivity
MeSH: Learning*, Visual Cortex*, Visual Pathways*, Animals, Humans, Models, Neurological, Neurons, Superior Colliculi (* major topic)
Journal subjects: Neuroscience, Computational Biology
Topic: Memory and Neural Mechanisms (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: NIH (NIH NIMH F32 MH139270); United States Department of Defense | United States Navy | Office of Naval Research (ONR) (ONR MURI grant N00014-19-1-2571, DURIP N00014-17-1-2304); HHS | NIH | National Institute of Mental Health (NIMH) (NIMH R01 MH120073); Australian Government (AUSMURIB000001)
Citations: not cited yet (Europe PMC); 88 references in the paper

Abstract

Recent experimental studies have found diverse spatial properties, such as head direction tuning and egocentric tuning, of neurons in the postrhinal cortex (POR) and revealed how the POR spatial representations are distinct from the retrosplenial cortex (RSC). However, how these spatial properties of POR neurons emerge is unknown, and the cause of distinct cortical spatial representations is also unclear. We have previously modeled spatial tuning in RSC based on processing of static visual features originating from the LGN-V1 pathway. However, recent studies have indicated that visual inputs to POR primarily reflect motion processing originating in the superior colliculus (SC). Here, we build a new learning model based on the computation of optic flow information in the SC. This SC-based optic flow model produces simulated neurons with spatial tuning that reflects the diverse spatial properties of POR neurons. Moreover, comparing the new optic flow model with our previously proposed static feature model, we show that distinct cortical spatial representations similar to those found in POR and RSC can be learned along disparate visual pathways (originating in SC and V1), suggesting that the varying features encoded in different visual pathways contribute to the distinct spatial properties in downstream cortical areas.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Repositories

Its files are read in the Code ↔ Paper reader above, with 3 matches between paragraphs and lines of code.

Zenodo 21088614

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 1 file
Software Heritage: not checked
Found in: “Data, code, and materials availability:”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
695 files

Zenodo 13502205

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 1 file
Software Heritage: not checked
Found in: “Data, code, and materials availability:”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)

hasselmonians/lachance_hasselmo_por_rsc

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: 0cc93e729f43f252700e45e2b4905b83865bdee5, 29 August 2024
Languages: Python (4)
Size: 94 files, 4 scripts
Software Heritage: not archived
Found in: the Zenodo archive record
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: NumPy (3 files), Matplotlib (2 files), Numba (1 file), pandas (1 file), SciPy (1 file), seaborn (1 file)
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
5 files

yanbolian/learning-distinct-egocentric-cells

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: 2c30bbf6f8597d3760f8f7d54d59698b73663197, 29 May 2026
Languages: MATLAB (658), C (23), C/C++ (13)
Size: 1,428 files, 694 scripts
Software Heritage: not archived
Found in: the Zenodo archive record
Holds: README, tests, documentation
Not found: license file, CITATION.cff, environment file, continuous integration
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
695 files

The paper's code and data availability statement is in the Data section.

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  • 4 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 1,392 scripts, each with its path and the digest of its content;
  • 3 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data, code, and materials availability

All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/or the Supplementary Materials. Code for implementing the model and model data are available at https://zenodo.org/records/21088614. Example experimental data and analysis code for data from LaChance and Hasselmo (16) are available at https://doi.org/10.5281/zenodo.13502205. This study did not generate new materials.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 8 MeSH terms, 4 funders, 84 references.

Cite

This paper

Lian, Y., LaChance, P. A., Malmberg, S., Hasselmo, M. E., & Burkitt, A. N. (2026). Distinct cortical spatial representations learned along disparate visual pathways. Science advances, 12(33), eaea1037. https://doi.org/10.1126/sciadv.aea1037

BibTeX

@article{lian2026distinct,
author = {Lian, Yanbo and LaChance, Patrick A. and Malmberg, Samantha and Hasselmo, Michael E. and Burkitt, Anthony N.},
title = {{Distinct cortical spatial representations learned along disparate visual pathways}},
journal = {Science advances},
year = {2026},
month = aug,
volume = {12},
number = {33},
pages = {eaea1037},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/sciadv.aea1037},
url = {https://doi.org/10.1126/sciadv.aea1037},
pmid = {42600021},
pmcid = {PMC13475576}
}

RIS

TY - JOUR
AU - Lian, Yanbo
AU - LaChance, Patrick A.
AU - Malmberg, Samantha
AU - Hasselmo, Michael E.
AU - Burkitt, Anthony N.
TI - Distinct cortical spatial representations learned along disparate visual pathways
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/08/14
VL - 12
IS - 33
SP - eaea1037
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/sciadv.aea1037
UR - https://doi.org/10.1126/sciadv.aea1037
LA - en
ER -

CSL-JSON

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"PMCID": "PMC13475576",
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