Diverse ancestral myosin motors generate and segregate distinct types of nanocluster-rich domains at the plasma membrane.
Overview
- National Centre for Biological Sciences, Bangalore, India
- Fundación Agencia Aragonesa para la Investigación y el Desarrollo (ARAID), Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza and CIBER-BBN, Zaragoza, Spain
- Warwick Medical School, University of Warwick, Coventry, UK
- Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, Bangalore, India
- School of Life Sciences and Department of Chemistry, University of Warwick, Coventry, UK
- Trans-disciplinary University, Bangalore, India
- CSIR–Indian Institute of Integrative Medicine, Jammu, India
Abstract
Molecular organization of the plasma membrane at nano- and micrometer scales is critical for its function in all living cells. This emerges not only from the self-assembly of lipids and proteins but also from active forces originating in the underlying cytoskeletal cortex. These forces drive membrane molecules into nonequilibrium steady-state patterns such as nanoclusters. However, the molecular agents connecting membrane organization with cytoskeletal dynamics and stresses have remained unknown. Here, we show that two classes of ubiquitous ancestral nonmuscle myosins are deployed for the organization of different types of membrane components. Inner leaflet–localized class I myosins link outerleaflet glycosylphosphatidylinos
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Zenodo 21241290
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Data
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All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 5 MeSH terms, 1 funder, 66 references.
Cite
This paper
Sil, P., van Zanten, T. S., Jahnavi, S., Bansal, A., Razmazma, H., Saha, S., Mahajan, B., Kumar, M., Stansfeld, P. J., Singh, P. P., Rao, M., & Mayor, S. (2026). Diverse ancestral myosin motors generate and segregate distinct types of nanocluster-rich domains at the plasma membrane. Science advances, 12(37), eaeb8889. https://
BibTeX
@article{sil2026diverse,
author = {Sil, Parijat and van Zanten, Thomas S and Jahnavi, Sowmya and Bansal, Ajay and Razmazma, Hafez and Saha, Suvrajit and Mahajan, Bhagyashri and Kumar, Mukesh and Stansfeld, Phillip J and Singh, Parvinder Pal and Rao, Madan and Mayor, Satyajit},
title = {{Diverse ancestral myosin motors generate and segregate distinct types of nanocluster-rich domains at the plasma membrane}},
journal = {Science advances},
year = {2026},
month = sep,
volume = {12},
number = {37},
pages = {eaeb8889},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/
url = {https://
pmid = {42726867},
pmcid = {PMC13564907}
}
RIS
TY - JOUR
AU - Sil, Parijat
AU - van Zanten, Thomas S
AU - Jahnavi, Sowmya
AU - Bansal, Ajay
AU - Razmazma, Hafez
AU - Saha, Suvrajit
AU - Mahajan, Bhagyashri
AU - Kumar, Mukesh
AU - Stansfeld, Phillip J
AU - Singh, Parvinder Pal
AU - Rao, Madan
AU - Mayor, Satyajit
TI - Diverse ancestral myosin motors generate and segregate distinct types of nanocluster-rich domains at the plasma membrane
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/
VL - 12
IS - 37
SP - eaeb8889
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/
UR - https://
LA - en
ER -
CSL-JSON
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