OSCR

AMPKγ2 Regulates Cardiac Hypertrophy and Arrhythmias via Interacting With Myosin.

Overview

Authors: Qianyun Ge1,2, Kusumika Saha3,4, Micah L Burch3,4, Willow H Battista3, Ashmita KC3, Max Homilius3,4, Rachelle A Victorio3, Dajun Quan3, Hsiang-Ling Huang5,2, Joseph M Hazel5,2, Alex Williams3, Emily Pan3,4, Krishna Chinthalapudi5,2, Sarah M Heissler5,2, Calum A MacRae3,4, Wandi Zhu1,2
ORCID iDs: Qianyun Ge, Kusumika Saha, Max Homilius, Rachelle A Victorio, Dajun Quan, Hsiang-Ling Huang, Krishna Chinthalapudi, Sarah M Heissler, Calum A MacRae, Wandi Zhu
  1. Department of Molecular Medicine and Therapeutics (Q.G., W.Z.), The Ohio State University, College of Medicine, Columbus
  2. Dorothy M. Davis Heart and Lung Research Institute (Q.G., H.-L.H., J.M.H., K.C., S.M.H., W.Z.), The Ohio State University, College of Medicine, Columbus
  3. Department of Medicine, Brigham and Women’s Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.)
  4. Harvard Medical School, Boston, MA (K.S., M.L.B., M.H., E.P., C.A.M.)
  5. Department of Physiology and Cell Biology (H.-L.H., J.M.H., K.C., S.M.H.), The Ohio State University, College of Medicine, Columbus
Institutions: The Ohio State University (United States); Brigham and Women's Hospital (United States)
Journal: Circulation research, volume 139, issue 5, article e328910
Dates: received 20 April 2026; accepted 18 June 2026; published online 9 July 2026; in print 14 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1161/circresaha.126.328910 · PMID 42422944 · PMCID PMC13475725 · OpenAlex W7167792124
Open access: hybrid, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), zebrafish (organism), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials
Keywords: arrhythmias, cardiac, cardiomyopathy, hypertrophic, electrophysiology, glycogen, hypertrophy, myocytes, myosins
MeSH: AMP-Activated Protein Kinases*, Arrhythmias, Cardiac*, Cardiomegaly*, Zebrafish Proteins*, Action Potentials, Animals, Animals, Genetically Modified, Glycogen, Humans, Myocardial Contraction, Myocytes, Cardiac, Phosphorylation, Zebrafish (* major topic)
Topic: Metabolism, Diabetes, and Cancer (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: NHLBI NIH HHS (R01 HL181868, R01 HL164675); NIH HHS (R24 OD035402)
Citations: cited by 1 paper (Europe PMC); 30 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: NCBI GEO GSE333349
  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1161/circresaha.126.328910.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Lippincott Williams & Wilkins

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 9 keywords, 13 MeSH terms, 2 funders, 30 references.

Cite

This paper

Ge, Q., Saha, K., Burch, M. L., Battista, W. H., KC, A., Homilius, M., Victorio, R. A., Quan, D., Huang, H.-L., Hazel, J. M., Williams, A., Pan, E., Chinthalapudi, K., Heissler, S. M., MacRae, C. A., & Zhu, W. (2026). AMPKγ2 Regulates Cardiac Hypertrophy and Arrhythmias via Interacting With Myosin. Circulation research, 139(5), e328910. https://doi.org/10.1161/circresaha.126.328910

BibTeX

@article{ge2026ampk2,
author = {Ge, Qianyun and Saha, Kusumika and Burch, Micah L and Battista, Willow H and KC, Ashmita and Homilius, Max and Victorio, Rachelle A and Quan, Dajun and Huang, Hsiang-Ling and Hazel, Joseph M and Williams, Alex and Pan, Emily and Chinthalapudi, Krishna and Heissler, Sarah M and MacRae, Calum A and Zhu, Wandi},
title = {{AMPKγ2 Regulates Cardiac Hypertrophy and Arrhythmias via Interacting With Myosin}},
journal = {Circulation research},
year = {2026},
month = jul,
volume = {139},
number = {5},
pages = {e328910},
publisher = {Lippincott Williams \& Wilkins},
issn = {0009-7330},
doi = {10.1161/circresaha.126.328910},
url = {https://doi.org/10.1161/circresaha.126.328910},
pmid = {42422944},
pmcid = {PMC13475725}
}

RIS

TY - JOUR
AU - Ge, Qianyun
AU - Saha, Kusumika
AU - Burch, Micah L
AU - Battista, Willow H
AU - KC, Ashmita
AU - Homilius, Max
AU - Victorio, Rachelle A
AU - Quan, Dajun
AU - Huang, Hsiang-Ling
AU - Hazel, Joseph M
AU - Williams, Alex
AU - Pan, Emily
AU - Chinthalapudi, Krishna
AU - Heissler, Sarah M
AU - MacRae, Calum A
AU - Zhu, Wandi
TI - AMPKγ2 Regulates Cardiac Hypertrophy and Arrhythmias via Interacting With Myosin
T2 - Circulation research
J2 - Circ Res
PY - 2026
DA - 2026/07/09
VL - 139
IS - 5
SP - e328910
SN - 0009-7330
PB - Lippincott Williams & Wilkins
DO - 10.1161/circresaha.126.328910
UR - https://doi.org/10.1161/circresaha.126.328910
LA - en
ER -

CSL-JSON

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"container-title-short": "Circ Res",
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"PMID": "42422944",
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"language": "en",
"issued": {
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