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Identification of the adhesion GPCR ADGRL4/ELTD1 as a novel potential prognostic biomarker for cerebral cavernous malformation disease.

Overview

Authors: Andrea Perrelli1,2,3, Ashraqat Ahmed4, Anna Onisiforou5, Gwenola Boulday6, Juan Zalvide7, Celia M Pombo7, José E Martínez7, Alessio Paolini8, Salim Abdelilah-Seyfried8, Ioannis Petrakakis4, Wolfram S Kunz9, Robert Geffers10, Christian Hartmann11, Walter Bini4, Gerasimos Baltsavias4, Amir Samii4, Helmut Bertalanffy4, Saverio F Retta2,3, Angela J Glading1, Souvik Kar4
  1. Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642 USA
  2. Department of Clinical and Biological Sciences, University of Torino, Orbassano, Turin, 10043 Italy
  3. CCM Italia Research Network, National Coordination Center at the Department of Clinical and Biological Sciences, University of Torino, Orbassano, Turin, 10043 Italy
  4. International Neuroscience Institute, Rudolf-Pichlmayr-Strasse 4, Hannover, 30625 Germany
  5. Department of Psychology, University of Cyprus, Nicosia, 1057 Cyprus
  6. Institut du Cerveau Et de La Moelle Épinière, ICM, Inserm U1127, CNRS UMR 7225, Sorbonne Université, Paris, 75013 France
  7. Department of Physiology, Centro Singular de Medicina Molecular E Enfermedades Crónicas (CiMUS), Instituto Sanitario de Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, A Coruña, Spain
  8. Institute of Biochemistry and Biology, Universität Potsdam, Karl-Liebknecht Strasse 24-25, Potsdam-Golm, 14476 Germany
  9. Institute of Experimental Epileptology and Cognition Research and Department of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127 Germany
  10. Genome Analytics, Helmholtz Centre for Infection Research, Brunswick, 38124 Germany
  11. Department of Neuropathology, Institute of Pathology, Hannover Medical School, Carl-Neuberg-Straße 1, Hannover, 30625 Germany
Institutions: University of Rochester Medicine (United States); University of Rochester (United States); University of Turin (Italy); International Neuroscience Institute (Germany); University of Cyprus (Cyprus); Centre National de la Recherche Scientifique (France); Inserm (France); Sorbonne Université (France); Institut du Cerveau (France); Universidade de Santiago de Compostela (Spain); Center for Research in Molecular Medicine and Chronic Diseases (Spain); Instituto de Investigación Sanitaria de Santiago (Spain); University of Potsdam (Germany); University of Bonn (Germany); University Hospital Bonn (Germany); Helmholtz Centre for Infection Research (Germany); Medizinische Hochschule Hannover (Germany)
Journal: Molecular medicine (Cambridge, Mass.), volume 32, issue 1, article 98
Dates: received 5 August 2025; accepted 28 April 2026; published online 8 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s10020-026-01495-4 · PMID 42098603 · PMCID PMC13321542 · OpenAlex W7160531396
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), mouse (organism), clinical / translational (subfield)
Methods: Statistics, Machine learning, Connectivity, fMRI & imaging
Keywords: ADGRL4/ELTD1, Angiogenesis, Biomarkers, Cerebral Cavernous Malformation (CCM), Diagnostic biomarkers, Prognostic biomarkers, RNA transcriptome
MeSH: Hemangioma, Cavernous, Central Nervous System*, Receptors, G-Protein-Coupled*, Adult, Animals, Biomarkers, Female, Gene Expression Profiling, Humans, Male, Mice, Middle Aged, Prognosis (* major topic)
Topic: Vascular Malformations Diagnosis and Treatment (Neurology, Medicine), according to OpenAlex
Funding: Deutsche Forschungsgemeinschaft (SE2016/10-1); National Institutes of Health (1HL141131); American Heart Association (24POST1191892); Ministerio de Ciencia, Innovación y Universidades (PID2021-123365OB-I00); Fondation Leducq (21CVD03 - ReVAMP); Ministerio de Ciencia, Innovación y Universidades,Spain (SFB958); era-net Neuron (01EW2306); NIH HHS (1HL141131)
Citations: not cited yet (Europe PMC); 61 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1186/s10020-026-01495-4.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 7 keywords, 12 MeSH terms, 8 funders, 61 references.

Cite

This paper

Perrelli, A., Ahmed, A., Onisiforou, A., Boulday, G., Zalvide, J., Pombo, C. M., Martínez, J. E., Paolini, A., Abdelilah-Seyfried, S., Petrakakis, I., Kunz, W. S., Geffers, R., Hartmann, C., Bini, W., Baltsavias, G., Samii, A., Bertalanffy, H., Retta, S. F., Glading, A. J., & Kar, S. (2026). Identification of the adhesion GPCR ADGRL4/ELTD1 as a novel potential prognostic biomarker for cerebral cavernous malformation disease. Molecular medicine (Cambridge, Mass.), 32(1), 98. https://doi.org/10.1186/s10020-026-01495-4

BibTeX

@article{perrelli2026identification,
author = {Perrelli, Andrea and Ahmed, Ashraqat and Onisiforou, Anna and Boulday, Gwenola and Zalvide, Juan and Pombo, Celia M and Martínez, José E and Paolini, Alessio and Abdelilah-Seyfried, Salim and Petrakakis, Ioannis and Kunz, Wolfram S and Geffers, Robert and Hartmann, Christian and Bini, Walter and Baltsavias, Gerasimos and Samii, Amir and Bertalanffy, Helmut and Retta, Saverio F and Glading, Angela J and Kar, Souvik},
title = {{Identification of the adhesion GPCR ADGRL4/ELTD1 as a novel potential prognostic biomarker for cerebral cavernous malformation disease}},
journal = {Molecular medicine (Cambridge, Mass.)},
year = {2026},
month = may,
volume = {32},
number = {1},
pages = {98},
publisher = {The Feinstein Institute for Medical Research},
issn = {1076-1551},
doi = {10.1186/s10020-026-01495-4},
url = {https://doi.org/10.1186/s10020-026-01495-4},
pmid = {42098603},
pmcid = {PMC13321542}
}

RIS

TY - JOUR
AU - Perrelli, Andrea
AU - Ahmed, Ashraqat
AU - Onisiforou, Anna
AU - Boulday, Gwenola
AU - Zalvide, Juan
AU - Pombo, Celia M
AU - Martínez, José E
AU - Paolini, Alessio
AU - Abdelilah-Seyfried, Salim
AU - Petrakakis, Ioannis
AU - Kunz, Wolfram S
AU - Geffers, Robert
AU - Hartmann, Christian
AU - Bini, Walter
AU - Baltsavias, Gerasimos
AU - Samii, Amir
AU - Bertalanffy, Helmut
AU - Retta, Saverio F
AU - Glading, Angela J
AU - Kar, Souvik
TI - Identification of the adhesion GPCR ADGRL4/ELTD1 as a novel potential prognostic biomarker for cerebral cavernous malformation disease
T2 - Molecular medicine (Cambridge, Mass.)
J2 - Mol Med
PY - 2026
DA - 2026/05/08
VL - 32
IS - 1
SP - 98
SN - 1076-1551
PB - The Feinstein Institute for Medical Research
DO - 10.1186/s10020-026-01495-4
UR - https://doi.org/10.1186/s10020-026-01495-4
LA - en
ER -

CSL-JSON

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