OSCR

Early life stress induces brain-wide electrical network predisposition to migraine.

Overview

Authors: Micah Johnson1,2, Maureen Eberle1,2, Ian Hultman3, Xinyu Zhang3,4, Yassine Filali1,2, Benjamin Hing1, Molly Matkovich1, Alli Jimenez1,5, Sara Mitchell1,2, Anjayooluwa Adegboyo6, Radha Velamuri1, Julia Miller1,7, Kung-Sik Chan3, Sanvesh Srivastava3, Rainbo Hultman1,8,9
ORCID iDs: Sara Mitchell, Julia Miller
  1. Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA USA
  2. Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA USA
  3. Department of Statistics and Actuarial Science, University of Iowa, Iowa City, IA USA
  4. Present Address: School of Statistics, East China Normal University, Shanghai, China
  5. Present Address: University of North Carolina at Chapel Hill, Chapel Hill, NC USA
  6. University of Maryland Baltimore County, Baltimore, MD USA
  7. Present Address: University of California, Los Angeles, Los Angeles, CA USA
  8. Department of Psychiatry, University of Iowa, Iowa City, IA USA
  9. Department of Molecular Physiology & Biophysics, Iowa Neuroscience Institute, 51 Newton Rd., 6–510 Bowen Science Building, Iowa City, IA 52242 USA
Institutions: University of Iowa (United States); East China Normal University (China); University of North Carolina at Chapel Hill (United States); University of Maryland, Baltimore County (United States); University of California, Los Angeles (United States)
Journal: The journal of headache and pain, volume 27, issue 1, article 177
Dates: received 27 August 2025; accepted 18 May 2026; published online 13 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s10194-026-02399-8 · PMID 42288719 · PMCID PMC13352996 · OpenAlex W7164650689
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: extracellular electrophysiology (units, LFP) (modality), mouse (organism), pain (population)
Methods: Spectral & time-frequency, Statistics, Machine learning, Connectivity, Physiology & signal measures
Keywords: Migraine, CGRP (calcitonin gene-related peptide), Brain networks, Early life stress, Local field potentials (LFPs)
MeSH: Brain*, Migraine Disorders*, Nerve Net*, Stress, Psychological*, Animals, Calcitonin Gene-Related Peptide, Disease Models, Animal, Disease Susceptibility, Male, Mice (* major topic)
Topic: Migraine and Headache Studies (Psychiatry and Mental health, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 143 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1186/s10194-026-02399-8.

Tracing map

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Data

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Availability statements

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  • they say that the data are available on request
  • they say that the code is available on request

Read them in the paper: doi.org/10.1186/s10194-026-02399-8.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 5 keywords, 10 MeSH terms, 138 references.

Cite

This paper

Johnson, M., Eberle, M., Hultman, I., Zhang, X., Filali, Y., Hing, B., Matkovich, M., Jimenez, A., Mitchell, S., Adegboyo, A., Velamuri, R., Miller, J., Chan, K.-S., Srivastava, S., & Hultman, R. (2026). Early life stress induces brain-wide electrical network predisposition to migraine. The journal of headache and pain, 27(1), 177. https://doi.org/10.1186/s10194-026-02399-8

BibTeX

@article{johnson2026early,
author = {Johnson, Micah and Eberle, Maureen and Hultman, Ian and Zhang, Xinyu and Filali, Yassine and Hing, Benjamin and Matkovich, Molly and Jimenez, Alli and Mitchell, Sara and Adegboyo, Anjayooluwa and Velamuri, Radha and Miller, Julia and Chan, Kung-Sik and Srivastava, Sanvesh and Hultman, Rainbo},
title = {{Early life stress induces brain-wide electrical network predisposition to migraine}},
journal = {The journal of headache and pain},
year = {2026},
month = jun,
volume = {27},
number = {1},
pages = {177},
publisher = {BMC},
issn = {1129-2369},
doi = {10.1186/s10194-026-02399-8},
url = {https://doi.org/10.1186/s10194-026-02399-8},
pmid = {42288719},
pmcid = {PMC13352996}
}

RIS

TY - JOUR
AU - Johnson, Micah
AU - Eberle, Maureen
AU - Hultman, Ian
AU - Zhang, Xinyu
AU - Filali, Yassine
AU - Hing, Benjamin
AU - Matkovich, Molly
AU - Jimenez, Alli
AU - Mitchell, Sara
AU - Adegboyo, Anjayooluwa
AU - Velamuri, Radha
AU - Miller, Julia
AU - Chan, Kung-Sik
AU - Srivastava, Sanvesh
AU - Hultman, Rainbo
TI - Early life stress induces brain-wide electrical network predisposition to migraine
T2 - The journal of headache and pain
J2 - J Headache Pain
PY - 2026
DA - 2026/06/13
VL - 27
IS - 1
SP - 177
SN - 1129-2369
PB - BMC
DO - 10.1186/s10194-026-02399-8
UR - https://doi.org/10.1186/s10194-026-02399-8
LA - en
ER -

CSL-JSON

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