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Transcranial direct current stimulation improves reduced global BOLD-CSF coupling in patients with insomnia disorder and comorbid anxiety: a resting-state functional MRI study.

Overview

Authors: Yanan Zhang1,2, Qingqing Sun1,2, Xiaotong Zhang1,2, Wanru Li1,2, Yaru Wang1,2, Lijia Cai1,2, Zan Wang1,2
  1. Sleep Center, Department of Neurology, The First Hospital of Jilin University, Xinmin Street No. 1, Changchun, 130021 China
  2. Stroke Center, Department of Neurology, The First Hospital of Jilin University, Xinmin Street No. 1, Changchun, 130021 China
Journal: BMC psychiatry, volume 26, issue 1, article 670
Dates: received 1 February 2026; accepted 11 June 2026; published online 17 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12888-026-08304-6 · PMID 42310658 · PMCID PMC13508550 · OpenAlex W7165033293
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: EEG (modality), fMRI (modality), other (modality), human (organism), other condition (population), sleep disorders (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Statistics, Machine learning, Preprocessing, Connectivity, fMRI & imaging, Single-unit activity, calcium imaging
Keywords: Insomnia disorder, Anxiety, Transcranial direct current stimulation, Resting-state functional magnetic resonance imaging, Glymphatic-related neurofluid dynamics
MeSH: Anxiety*, Anxiety Disorders*, Cerebrospinal Fluid*, Sleep Initiation and Maintenance Disorders*, Transcranial Direct Current Stimulation*, Adult, Comorbidity, Double-Blind Method, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Polysomnography, Treatment Outcome (* major topic)
Topic: Transcranial Magnetic Stimulation Studies (Neurology, Neuroscience), according to OpenAlex
Funding: National Key Research and Development Program of China; Brain Science and Brain-like Intelligence Technology - National Science and Technology Major Project
Citations: not cited yet (Europe PMC); 55 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1186/s12888-026-08304-6.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 16 MeSH terms, 2 funders, 55 references.

Cite

This paper

Zhang, Y., Sun, Q., Zhang, X., Li, W., Wang, Y., Cai, L., & Wang, Z. (2026). Transcranial direct current stimulation improves reduced global BOLD-CSF coupling in patients with insomnia disorder and comorbid anxiety: a resting-state functional MRI study. BMC psychiatry, 26(1), 670. https://doi.org/10.1186/s12888-026-08304-6

BibTeX

@article{zhang2026transcranial,
author = {Zhang, Yanan and Sun, Qingqing and Zhang, Xiaotong and Li, Wanru and Wang, Yaru and Cai, Lijia and Wang, Zan},
title = {{Transcranial direct current stimulation improves reduced global BOLD-CSF coupling in patients with insomnia disorder and comorbid anxiety: a resting-state functional MRI study}},
journal = {BMC psychiatry},
year = {2026},
month = jun,
volume = {26},
number = {1},
pages = {670},
publisher = {BMC},
issn = {1471-244X},
doi = {10.1186/s12888-026-08304-6},
url = {https://doi.org/10.1186/s12888-026-08304-6},
pmid = {42310658},
pmcid = {PMC13508550}
}

RIS

TY - JOUR
AU - Zhang, Yanan
AU - Sun, Qingqing
AU - Zhang, Xiaotong
AU - Li, Wanru
AU - Wang, Yaru
AU - Cai, Lijia
AU - Wang, Zan
TI - Transcranial direct current stimulation improves reduced global BOLD-CSF coupling in patients with insomnia disorder and comorbid anxiety: a resting-state functional MRI study
T2 - BMC psychiatry
J2 - BMC Psychiatry
PY - 2026
DA - 2026/06/17
VL - 26
IS - 1
SP - 670
SN - 1471-244X
PB - BMC
DO - 10.1186/s12888-026-08304-6
UR - https://doi.org/10.1186/s12888-026-08304-6
LA - en
ER -

CSL-JSON

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"title": "Transcranial direct current stimulation improves reduced global BOLD-CSF coupling in patients with insomnia disorder and comorbid anxiety: a resting-state functional MRI study",
"container-title": "BMC psychiatry",
"author": [
{
"family": "Zhang",
"given": "Yanan"
},
{
"family": "Sun",
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{
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}
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"container-title-short": "BMC Psychiatry",
"volume": "26",
"issue": "1",
"page": "670",
"DOI": "10.1186/s12888-026-08304-6",
"PMID": "42310658",
"PMCID": "PMC13508550",
"ISSN": "1471-244X",
"publisher": "BMC",
"URL": "https://doi.org/10.1186/s12888-026-08304-6",
"language": "en",
"issued": {
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]
}
}

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