OSCR

Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spines.

Overview

Authors: Gisela Besa-Selva1,2,3, Esther García-García1,2,3, Alba Ramón-Lainez1,2,3, Georgia Escaramis1, Pol Garcia-Segura1,3, Cristina Malagelada1,2,3, Eulàlia Martí1,2, Jordi Alberch1,2,3,4, Mercè Masana1,2,3, Manuel J Rodríguez1,2,3
  1. Department of Biomedical Sciences, School of Medicine and Health Sciences, Institute of Neurosciences, Universitat de Barcelona, C/Casanova 143, Barcelona, 08036 Spain
  2. August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, 08036 Spain
  3. Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED), Ministerio de Ciencia e Innovación, Madrid, Spain
  4. Production and Validation Center of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, University of Barcelona, Barcelona, 08036 Spain
Institutions: Biomedical Research Networking Center on Neurodegenerative Diseases (Spain); Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (Spain); Ministerio de Ciencia, Innovación y Universidades (Spain); Universitat de Barcelona (Spain)
Journal: BMC biology, volume 24, issue 1, article 180
Dates: received 2 July 2025; accepted 27 May 2026; published online 3 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12915-026-02649-w · PMID 42237281 · PMCID PMC13450030 · OpenAlex W7163356899
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Preprocessing, Connectivity
Keywords: VPS13A disease, Basal ganglia disorders, Lipidomics, DAG, Glycerophospholipids, Synapse
MeSH: Diglycerides*, Neurons*, Protein Kinase C*, Signal Transduction*, Vesicular Transport Proteins*, Animals, Gene Knockdown Techniques, Mice (* major topic)
Topic: Genetic Neurodegenerative Diseases (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Citations: not cited yet (Europe PMC); 67 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: figshare 32083563
  • it says that the data are available on request

Read it in the paper: doi.org/10.1186/s12915-026-02649-w.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 6 keywords, 8 MeSH terms, 67 references.

Cite

This paper

Besa-Selva, G., García-García, E., Ramón-Lainez, A., Escaramis, G., Garcia-Segura, P., Malagelada, C., Martí, E., Alberch, J., Masana, M., & Rodríguez, M. J. (2026). Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spines. BMC biology, 24(1), 180. https://doi.org/10.1186/s12915-026-02649-w

BibTeX

@article{besaselva2026neuronal,
author = {Besa-Selva, Gisela and García-García, Esther and Ramón-Lainez, Alba and Escaramis, Georgia and Garcia-Segura, Pol and Malagelada, Cristina and Martí, Eulàlia and Alberch, Jordi and Masana, Mercè and Rodríguez, Manuel J},
title = {{Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spines}},
journal = {BMC biology},
year = {2026},
month = jun,
volume = {24},
number = {1},
pages = {180},
publisher = {BMC},
issn = {1741-7007},
doi = {10.1186/s12915-026-02649-w},
url = {https://doi.org/10.1186/s12915-026-02649-w},
pmid = {42237281},
pmcid = {PMC13450030}
}

RIS

TY - JOUR
AU - Besa-Selva, Gisela
AU - García-García, Esther
AU - Ramón-Lainez, Alba
AU - Escaramis, Georgia
AU - Garcia-Segura, Pol
AU - Malagelada, Cristina
AU - Martí, Eulàlia
AU - Alberch, Jordi
AU - Masana, Mercè
AU - Rodríguez, Manuel J
TI - Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spines
T2 - BMC biology
J2 - BMC Biol
PY - 2026
DA - 2026/06/03
VL - 24
IS - 1
SP - 180
SN - 1741-7007
PB - BMC
DO - 10.1186/s12915-026-02649-w
UR - https://doi.org/10.1186/s12915-026-02649-w
LA - en
ER -

CSL-JSON

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