OSCR

Loss of astrocytic Bmal1 promotes blood-brain barrier disruption and synaptic dysfunction during systemic inflammation.

Overview

Authors: Changjun Lee1, Yelin Lee2, Woo Chan Jeong2, Inhwa Hwang1, Harin Bae1, Do-Wan Shim1, Hyeji Jung2,3, Ji Won Um2,3, Je-Wook Yu1
ORCID iDs: Je-Wook Yu
  1. Department of Microbiology and Immunology, Brain Korea 21 Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, 03722 Republic of Korea
  2. Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988 Republic of Korea
  3. Center for Synapse Diversity and Specificity, DGIST, Daegu, 42988 Republic of Korea
Institutions: Yonsei University (South Korea); Yonsei University Health System (South Korea); Daegu Gyeongbuk Institute of Science and Technology (South Korea)
Journal: Journal of neuroinflammation, volume 23, issue 1, article 220
Dates: received 11 November 2025; accepted 24 April 2026; published online 6 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03841-z · PMID 42093016 · PMCID PMC13317409 · OpenAlex W7160403897
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Connectivity
Keywords: Bmal1, Blood-brain barrier, circadian rhythm, astrocyte, CXCL5
MeSH: ARNTL Transcription Factors*, Astrocytes*, Blood-Brain Barrier*, Circadian Rhythm*, Neuroinflammatory Diseases*, Animals, Chemokine CXCL5, Circadian Clocks, Female, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Interleukin-8B, Synaptic Transmission (* major topic)
Topic: Barrier Structure and Function Studies (Neurology, Neuroscience), according to OpenAlex
Funding: Korea Health Industry Development Institute (RS-2024-00405260); National Research Foundation of Korea (RS-2023-00207834, RS-2023-NR076948)
Citations: cited by 2 papers (Europe PMC); 44 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1186/s12974-026-03841-z.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 15 MeSH terms, 2 funders, 43 references.

Cite

This paper

Lee, C., Lee, Y., Jeong, W. C., Hwang, I., Bae, H., Shim, D.-W., Jung, H., Um, J. W., & Yu, J.-W. (2026). Loss of astrocytic Bmal1 promotes blood-brain barrier disruption and synaptic dysfunction during systemic inflammation. Journal of neuroinflammation, 23(1), 220. https://doi.org/10.1186/s12974-026-03841-z

BibTeX

@article{lee2026loss,
author = {Lee, Changjun and Lee, Yelin and Jeong, Woo Chan and Hwang, Inhwa and Bae, Harin and Shim, Do-Wan and Jung, Hyeji and Um, Ji Won and Yu, Je-Wook},
title = {{Loss of astrocytic Bmal1 promotes blood-brain barrier disruption and synaptic dysfunction during systemic inflammation}},
journal = {Journal of neuroinflammation},
year = {2026},
month = may,
volume = {23},
number = {1},
pages = {220},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03841-z},
url = {https://doi.org/10.1186/s12974-026-03841-z},
pmid = {42093016},
pmcid = {PMC13317409}
}

RIS

TY - JOUR
AU - Lee, Changjun
AU - Lee, Yelin
AU - Jeong, Woo Chan
AU - Hwang, Inhwa
AU - Bae, Harin
AU - Shim, Do-Wan
AU - Jung, Hyeji
AU - Um, Ji Won
AU - Yu, Je-Wook
TI - Loss of astrocytic Bmal1 promotes blood-brain barrier disruption and synaptic dysfunction during systemic inflammation
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/05/06
VL - 23
IS - 1
SP - 220
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03841-z
UR - https://doi.org/10.1186/s12974-026-03841-z
LA - en
ER -

CSL-JSON

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"ISSN": "1742-2094",
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"language": "en",
"issued": {
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