OSCR

Translational evidence for increased central amygdala IL-6 activity in alcohol dependence.

Overview

Authors: Celsey M. St. Onge1, Chloe Erikson1, Bryan Cruz1,2, Vittoria Borgonetti1,3, Joel G. Hashimoto4,5, Jessica A. Cucinello-Ragland6, Taylor Fitzpatrick-Schmidt6, Larry Rodriguez1, Sophia Khom1,7, Michela Palmisano1, Roman Vlkolinsky1, Christopher S. Oleata1, Tali Nadav8, Nihal A. Salem9, Scott Edwards6, R. Dayne Mayfield9, Marina Guizzetti4,5, Amanda J. Roberts8, Michal Bajo1, Marisa Roberto1,8
ORCID iDs: Sophia Khom, Michela Palmisano, Roman Vlkolinsky
  1. Department of Translational Medicine, The Scripps Research Institute,10550 N. Torrey Pines Rd, La Jolla, CA USA
  2. Department of Pharmacology, Addiction Science, and Toxicology, The University of Tennessee Health Science Center,Memphis, TN USA
  3. Department of Molecular and Developmental Medicine, University of Siena,Siena, Italy
  4. Department of Behavioral Neuroscience, Oregon Health & Science University,Portland, OR USA
  5. VA Portland Health Care System,Portland, OR USA
  6. Department of Physiology and Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health,New Orleans, LA USA
  7. Department of Pharmaceutical Sciences, University of Vienna,Vienna, Austria
  8. Animal Models Core Facility, The Scripps Research Institute,La Jolla, CA USA
  9. Department of Neuroscience and Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin,Austin, TX USA
Institutions: Scripps Research Institute (United States); University of Tennessee Health Science Center (United States); University of Siena (Italy); Oregon Health & Science University (United States); VA Portland Health Care System (United States); Louisiana State University (United States); University of Vienna (Austria); The University of Texas at Austin (United States)
Journal: Journal of neuroinflammation, volume 23, issue 1, article 211
Dates: received 3 March 2026; accepted 7 May 2026; published online 22 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03868-2 · PMID 42174622 · PMCID PMC13292440 · OpenAlex W7162130838
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), histology / microscopy (modality), human (organism), mouse (organism), other condition (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Statistics, Preprocessing, Evoked potentials
Keywords: Human, Mouse, Cytokine, Ethanol, Electrophysiology, Gene expression, RNA-seq, RNAscope, Brain, Neuroimmune
MeSH: Alcoholism*, Central Amygdaloid Nucleus*, Interleukin-6*, Translational Research, Biomedical*, Animals, Ethanol, Female, Humans, Male, Mice, Mice, Inbred C57BL (* major topic)
Topic: Neurotransmitter Receptor Influence on Behavior (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; U.S. Department of Veterans Affairs
Citations: not cited yet (Europe PMC); 133 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Data links

Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1186/s12974-026-03868-2.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 10 keywords, 11 MeSH terms, 3 funders, 129 references.

Cite

This paper

St. Onge, C. M., Erikson, C., Cruz, B., Borgonetti, V., Hashimoto, J. G., Cucinello-Ragland, J. A., Fitzpatrick-Schmidt, T., Rodriguez, L., Khom, S., Palmisano, M., Vlkolinsky, R., Oleata, C. S., Nadav, T., Salem, N. A., Edwards, S., Mayfield, R. D., Guizzetti, M., Roberts, A. J., Bajo, M., & Roberto, M. (2026). Translational evidence for increased central amygdala IL-6 activity in alcohol dependence. Journal of neuroinflammation, 23(1), 211. https://doi.org/10.1186/s12974-026-03868-2

BibTeX

@article{stonge2026translational,
author = {St. Onge, Celsey M. and Erikson, Chloe and Cruz, Bryan and Borgonetti, Vittoria and Hashimoto, Joel G. and Cucinello-Ragland, Jessica A. and Fitzpatrick-Schmidt, Taylor and Rodriguez, Larry and Khom, Sophia and Palmisano, Michela and Vlkolinsky, Roman and Oleata, Christopher S. and Nadav, Tali and Salem, Nihal A. and Edwards, Scott and Mayfield, R. Dayne and Guizzetti, Marina and Roberts, Amanda J. and Bajo, Michal and Roberto, Marisa},
title = {{Translational evidence for increased central amygdala IL-6 activity in alcohol dependence}},
journal = {Journal of neuroinflammation},
year = {2026},
month = may,
volume = {23},
number = {1},
pages = {211},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03868-2},
url = {https://doi.org/10.1186/s12974-026-03868-2},
pmid = {42174622},
pmcid = {PMC13292440}
}

RIS

TY - JOUR
AU - St. Onge, Celsey M.
AU - Erikson, Chloe
AU - Cruz, Bryan
AU - Borgonetti, Vittoria
AU - Hashimoto, Joel G.
AU - Cucinello-Ragland, Jessica A.
AU - Fitzpatrick-Schmidt, Taylor
AU - Rodriguez, Larry
AU - Khom, Sophia
AU - Palmisano, Michela
AU - Vlkolinsky, Roman
AU - Oleata, Christopher S.
AU - Nadav, Tali
AU - Salem, Nihal A.
AU - Edwards, Scott
AU - Mayfield, R. Dayne
AU - Guizzetti, Marina
AU - Roberts, Amanda J.
AU - Bajo, Michal
AU - Roberto, Marisa
TI - Translational evidence for increased central amygdala IL-6 activity in alcohol dependence
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/05/22
VL - 23
IS - 1
SP - 211
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03868-2
UR - https://doi.org/10.1186/s12974-026-03868-2
LA - en
ER -

CSL-JSON

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