OSCR

Inhibition of endocannabinoid degradation in astrocytes reprograms glial reactivity and prevents seizure sequelae.

Overview

Authors: Chudai Zeng1,2, Fei Gao1, Mei Hu1, Jian Zhang1, Dexiao Zhu1, Li Sun1, Jianlu Lyu1, Mingzhe Pan1, Chu Chen1
  1. Department of Cellular and Integrative Physiology, Joe R. & Teresa Lozano Long School of Medicine, University of Texas at San Antonio Health Science Center, San Antonio, Texas, 78229 USA
  2. Xiangya Hospital, Xiangya School of Medicine, Central South University, Changsha, 410011 Hunan China
Institutions: Central South University (China); The University of Texas at San Antonio Health Science Center (United States); Xiangya Hospital Central South University (China)
Journal: Journal of neuroinflammation, volume 23, issue 1, article 256
Dates: received 4 February 2026; accepted 18 May 2026; published online 27 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03883-3 · PMID 42192420 · PMCID PMC13393616 · OpenAlex W7162458595
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), epilepsy (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Preprocessing, Evoked potentials, Connectivity, Spectral & time-frequency
Keywords: Epilepsy, 2-arachidonylglycerol, Monoacylglycerol lipase, Cannabinoid receptor, Astrocyte, Neuroinflammation
MeSH: Astrocytes*, Endocannabinoids*, Neuroglia*, Seizures*, Animals, Arachidonic Acids, Glycerides, Kainic Acid, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Monoacylglycerol Lipases, Status Epilepticus (* major topic)
Topic: Cannabis and Cannabinoid Research (Pharmacology, Medicine), according to OpenAlex
Funding: Joe R. & Teresa Lozano Long School of Medicine at UT Health San Antonio
Citations: not cited yet (Europe PMC); 83 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1186/s12974-026-03883-3.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 6 keywords, 14 MeSH terms, 1 funder, 78 references.

Cite

This paper

Zeng, C., Gao, F., Hu, M., Zhang, J., Zhu, D., Sun, L., Lyu, J., Pan, M., & Chen, C. (2026). Inhibition of endocannabinoid degradation in astrocytes reprograms glial reactivity and prevents seizure sequelae. Journal of neuroinflammation, 23(1), 256. https://doi.org/10.1186/s12974-026-03883-3

BibTeX

@article{zeng2026inhibition,
author = {Zeng, Chudai and Gao, Fei and Hu, Mei and Zhang, Jian and Zhu, Dexiao and Sun, Li and Lyu, Jianlu and Pan, Mingzhe and Chen, Chu},
title = {{Inhibition of endocannabinoid degradation in astrocytes reprograms glial reactivity and prevents seizure sequelae}},
journal = {Journal of neuroinflammation},
year = {2026},
month = may,
volume = {23},
number = {1},
pages = {256},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03883-3},
url = {https://doi.org/10.1186/s12974-026-03883-3},
pmid = {42192420},
pmcid = {PMC13393616}
}

RIS

TY - JOUR
AU - Zeng, Chudai
AU - Gao, Fei
AU - Hu, Mei
AU - Zhang, Jian
AU - Zhu, Dexiao
AU - Sun, Li
AU - Lyu, Jianlu
AU - Pan, Mingzhe
AU - Chen, Chu
TI - Inhibition of endocannabinoid degradation in astrocytes reprograms glial reactivity and prevents seizure sequelae
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/05/27
VL - 23
IS - 1
SP - 256
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03883-3
UR - https://doi.org/10.1186/s12974-026-03883-3
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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