OSCR

Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats.

Overview

Authors: Keelin Quirk1, Antonio Ladrón-de-Guevara2,3, Aditya Raghunandan4,5, Humberto Mestre6, Maiken Nedergaard3,7, Douglas H Kelley1
  1. Department of Mechanical Engineering, University of Rochester, Rochester, NY USA
  2. Department of Biomedical Engineering, University of Rochester, Rochester, NY USA
  3. Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY USA
  4. Department of Mechanical Engineering, University of Michigan-Dearborn, Dearborn, MI USA
  5. Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, MI 48109 USA
  6. Department of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston, MA USA
  7. Center for Translational Neuromedicine, University of Copenhagen, Copenhagen N, 2200 Denmark
Institutions: University of Rochester (United States); University of Rochester Medicine (United States); University of Michigan (United States); University of Michigan–Dearborn (United States); Harvard University (United States); Mass General Brigham (United States); University of Copenhagen (Denmark)
Journal: Fluids and barriers of the CNS, volume 23, issue 1, article 41
Dates: received 23 July 2025; accepted 18 February 2026; published online 7 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12987-026-00782-w · PMID 41794761 · PMCID PMC12980869 · OpenAlex W7134117879
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), rat (organism)
Methods: Spectral & time-frequency, Statistics, Physiology & signal measures
MeSH: Cerebrospinal Fluid*, Glymphatic System*, Pia Mater*, Animals, Male, Mice, Pulsatile Flow, Rats, Rats, Sprague-Dawley, Species Specificity (* major topic)
Topic: Cerebrospinal fluid and hydrocephalus (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: NINDS NIH HHS (U19 NS128613)
Citations: not cited yet (Europe PMC); 92 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1186/s12987-026-00782-w.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 10 MeSH terms, 1 funder, 88 references.

Cite

This paper

Quirk, K., Ladrón-de-Guevara, A., Raghunandan, A., Mestre, H., Nedergaard, M., & Kelley, D. H. (2026). Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats. Fluids and barriers of the CNS, 23(1), 41. https://doi.org/10.1186/s12987-026-00782-w

BibTeX

@article{quirk2026quantifying,
author = {Quirk, Keelin and Ladrón-de-Guevara, Antonio and Raghunandan, Aditya and Mestre, Humberto and Nedergaard, Maiken and Kelley, Douglas H},
title = {{Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats}},
journal = {Fluids and barriers of the CNS},
year = {2026},
month = mar,
volume = {23},
number = {1},
pages = {41},
publisher = {BMC},
issn = {2045-8118},
doi = {10.1186/s12987-026-00782-w},
url = {https://doi.org/10.1186/s12987-026-00782-w},
pmid = {41794761},
pmcid = {PMC12980869}
}

RIS

TY - JOUR
AU - Quirk, Keelin
AU - Ladrón-de-Guevara, Antonio
AU - Raghunandan, Aditya
AU - Mestre, Humberto
AU - Nedergaard, Maiken
AU - Kelley, Douglas H
TI - Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats
T2 - Fluids and barriers of the CNS
J2 - Fluids Barriers CNS
PY - 2026
DA - 2026/03/07
VL - 23
IS - 1
SP - 41
SN - 2045-8118
PB - BMC
DO - 10.1186/s12987-026-00782-w
UR - https://doi.org/10.1186/s12987-026-00782-w
LA - en
ER -

CSL-JSON

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"type": "article-journal",
"title": "Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats",
"container-title": "Fluids and barriers of the CNS",
"author": [
{
"family": "Quirk",
"given": "Keelin"
},
{
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"container-title-short": "Fluids Barriers CNS",
"volume": "23",
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"page": "41",
"DOI": "10.1186/s12987-026-00782-w",
"PMID": "41794761",
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"ISSN": "2045-8118",
"publisher": "BMC",
"URL": "https://doi.org/10.1186/s12987-026-00782-w",
"language": "en",
"issued": {
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]
}
}

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