Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.
The 1 match
- [1] § Methods › Measurements › Cognitive reserve ↔ 2024_Liebscher_DELCODE_MusicalActivity_and_BrainConnectivity/R_scripts/09_alluvial_plot_musical_activity.R, lines 42–97 · score 0.59 · 13–30, 30–65, Lifetime, LEQ, DELCODE, activity
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The authors' code
R · 97 lines · 5 KB · no license · 1 match
- ################################################################################
- ###creator: Maxie Liebscher
- ###creation date: 03/04/2023
- ###content: This script was created to compute an alluvial plot for the MELODY
- ###paper.
- ################################################################################
- ###########################clear environment####################################
- rm(list = ls())
- ######################installation of all packages##############################
- install.packages("readxl") ##needed to import excel tables
- install.packages("ggplot2") ##needed for plots
- install.packages("ggalluvial") ##needed for plots
- install.packages("ggsci") ##needed for plots
- install.packages("dplyr") ##needed for renaming columns
- library(readxl)
- library(ggplot2)
- library(ggalluvial)
- library(ggsci)
- library(dplyr)
- ##########################import of data########################################
- #baseline table
- mydata <- read_excel("Z:/User/2021_LiebscherM/2022_MELODY/02_data/01_in_progress_data/03_tables/02_BA_tables/01_final_BA/01_sample_selfmade_match/20220329_final_sample.xlsx")
- View(mydata)
- #baseline table DELCODE
- DELCODE <- read_excel("Z:/User/2021_LiebscherM/2022_MELODY/02_data/02_original_data/01_tables/01_DELCODE_DZNE/20210104_Antrag 196_Wirth_MusicBrain_20200804_AD Biomarker_repseudonymisiert.xlsx")
- #############################preparation of sample##############################
- ###merge data to get information about musical activity in 3 lifestages (information from LEQ)
- all_data <- merge(mydata, DELCODE[, c("...1", "...460", "...513", "...591")], by.x="repseudonym", by.y="...1")
- ###rename some columns
- final_data <- all_data %>% rename("music_13_30" = "...460", "music_30_65" = "...513", "music_65" = "...591")
- View(final_data)
- ###recode musical activity (see Böttcher et al., 2022) > for classification in high or low musical activity-frequency
- ##explanation: 0 = 0 musical activity -> is needed for filtering of participants, who are not over 65 years
- ##1= answer options 1 & 2, because they are less than 2 times a month -> low frequency
- ##2= answer options 3, 4 & 5, because they are equal or more than 2 times a month -> high frequency
- final_data$music_13_30_recode <- as.numeric(recode(as.numeric(final_data$music_13_30), '0' = '0', '1' = '1', '2' = '1', '3' = '2', '4' = '2', '5' = '2'))
- final_data$music_30_65_recode <- as.numeric(recode(as.numeric(final_data$music_30_65), '0' = '0', '1' = '1', '2' = '1', '3' = '2', '4' = '2', '5' = '2'))
- final_data$music_65_recode <- as.numeric(recode(as.numeric(final_data$music_65), '0' = '0', '1' = '1', '2' = '1', '3' = '2', '4' = '2', '5' = '2'))
- ###set all values of participants <65 years in variable music_65_recoded to NA
- ##because they could not give an answer to that, when they are not at that age
- final_data$music_65_recode[final_data$age < 65] <- NA
- ###only include participants with music factor = 1 (with musical activity)
- musicians<- subset(final_data, music_factor == 1)
- ###tranform to lodes form -> needed for alluvial plot (axes: column numbers of variables for x-axis)
- musicians_lodes <- to_lodes_form(as.data.frame(musicians),
- axes=37:39,
- id = "Repseudonym")
- #############################plotting###########################################
- ###Böttcher et al. approach
- setwd("C:/Users/liebscherm/Nextcloud/AG_WIRTH_2021/08_MELODY_2023/02_figures/03_MS")
- png("20230314_MELODY_alluvial_plot_musical_activity.png", width=10, height=8, res=400, units = "in")
- ggplot(musicians_lodes,
- aes(x = x , stratum = stratum, alluvium = Repseudonym,
- fill = stratum)) +
- scale_y_continuous(expand = expansion(mult = c(0, 0.05)), breaks = seq(0, 70, by = 10)) +
- scale_x_discrete(breaks = c("music_13_30_recode", "music_30_65_recode", "music_65_recode"), labels = c("13-30 years", "30-65 years", "over 65 years")) +
- #scale_x_discrete(limits = c("13-30", "30-65", "over 65"), expand = c(.05, .05)) +
- labs(x = "Life stage", y = "Participants with lifetime musical activity") +
- geom_flow(stat = "alluvium", lode.guidance = "frontback",
- color = "darkgray", reverse = FALSE, na.rm =TRUE, cement.alluvia = FALSE) +
- geom_stratum(reverse = FALSE, na.rm = TRUE) +
- scale_fill_manual("Lifetime musical activity",limits = c("2", "1"), values = c("lightcyan4", "darkgoldenrod1"), labels = c ("Higher frequency", "Lower frequency")) +
- #geom_label(stat = "stratum", aes(label = after_stat(stratum))) +
- theme(legend.position = c(0.85, 0.9), legend.background = element_blank(), legend.title = element_text(size = 18), legend.text = element_text(size = 18), axis.ticks.x = element_blank(), text = element_text(size = 18), panel.grid.major = element_blank(), panel.grid.minor = element_blank(),
- panel.background = element_blank(), axis.line = element_line(colour = "black"), axis.text = element_text(size = 18, colour = "black"), plot.title = element_text(lineheight=.8, face="bold", size = 18))
- dev.off()
09_alluvial_plot_musical_activity.R, no license · at the source
Overview
and 24 other authors
Sophia Stoecklein26,10, Renat Yakupov7,13, Gabriel Ziegler7, Frederic Brosseron5, Katharina Buerger9,10, Julian Hellmann-Regen14,24,27, Christoph Laske22,28, Robert Perneczky15,10,29,30, Oliver Peters14,24,27, Josef Priller24,25,31,32, Alfredo Ramirez5,6,33,34,35, Anja Schneider5,6, Annika Spottke5,36, Stefan Teipel11,12, Jens Wiltfang19,20,37, Frank Jessen5,18,30, Emrah Düzel7,13, Sandra Röske5, Michael Wagner5,6, Franka Glöckner38, Natalie L Marchant39, Olga Klimecki40, Miranka Wirth1, DELCODE study group40 affiliations
- German Center for Neurodegenerative Diseases (DZNE), Standort Dresden, Tatzberg 41, Dresden, 01307 Germany
- Faculty of Medicine Carl Gustav Carus, Institute for Medical Informatics and Biometry (IMB), Technische Universität Dresden, Dresden, Germany
- Center for the Neuroscience of Embodied Cognition (CeNEC) at the Brain and Creativity Institute, University of Southern California, Los Angeles, CA USA
- Department of Cognitive Neurology, MR-Research in Neurosciences, University Medical Center Göttingen, Göttingen, Germany
- German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
- Clinic for Geriatric Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany
- German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
- Berlin Center for Advanced Neuroimaging, Charité – Universitätsmedizin Berlin, Berlin, Germany
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
- German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
- German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany
- Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany
- Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany
- Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany
- Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
- Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK
- Department of Neuroradiology, University Hospital LMU, Munich, Germany
- Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany
- German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany
- Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany
- Department of Psychiatry and Psychotherapy, Otto-Von-Guericke University, Magdeburg, Germany
- German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany
- Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
- German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
- Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany
- Department of Radiology, Ludwig Maximilian University Hospital, Munich, Germany
- Charité Universitätsmedizin Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany
- Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, Section for Dementia Research, University of Tübingen, Tübingen, Germany
- Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany
- Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK
- University of Edinburgh and UK DRI, Edinburgh, UK
- Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Center for Mental Health (DZPG), Munich, Germany
- Cologne Excellence Cluster On Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Cologne, Germany
- Department of Psychiatry and Psychotherapy, Division of Neurogenetics and Molecular Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
- Department of Psychiatry & Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, San Antonio, TX USA
- Clinic for Parkinson’s, Sleep and Movement Disorders, Centre for Neurology, University Hospital Bonn, Bonn, Germany
- Department of Medical Sciences, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal
- Faculty of Psychology, Chair of Lifespan Developmental Neuroscience, TU Dresden, Dresden, Germany
- Division of Psychiatry, University College London, London, UK
- Biological Psychology, University of Innsbruck, Innsbruck, Austria
Abstract
Background: Potentially modifiable lifestyle and psychological factors may influence Alzheimer’s disease (AD)-related brain pathology and cognitive function, thereby influencing cognitive resilience in late life.
Objective: This cross-sectional study investigated associations and pathways between lifestyle and psychological factors related to cognitive reserve and psychological debt, AD-related biomarkers, and cognitive function, as well as potential differences in these associations between AD risk groups.
Methods: In total, 298 non-demented older adults (mean age = 69.5 years, 44% women) of the DELCODE study were included. Structural equation modeling was used to assess the associations between the constructs of cognitive reserve (education, occupational complexity, leisure activity participation) and psychological debt (depression and anxiety symptoms, neuroticism, sleep quality), manifest AD-related biomarkers (cerebrospinal fluid [CSF] amyloid-beta [Aβ] 42, splenial white matter hyperintensities [WMH], hippocampal volume), and latent cognitive function of increased AD risk (Preclinical Alzheimer’s Cognitive Composite [PACC]). In the structural equation model, biomarkers were transformed such that higher values indicated greater AD-related brain pathology and age was included as a covariate. Multigroup analyses assessed moderations by established AD risk modifiers, namely sex and apolipoprotein ε4 (APOE ε4) genotype.
Results: In the total sample, higher cognitive reserve was associated with better cognitive function (p = .005), independent of AD-related biomarkers. Higher cognitive reserve was associated with lower psychological debt (p = .035); however, neither construct showed a significant association with the AD-related biomarkers (p ≥ .177). AD-related biomarkers of CSF Aβ42 (p = .021), splenial WMH (p = .044), and hippocampal neurodegeneration (p = .007) were each independently associated with lower cognitive function. Most associations were comparable between AD risk groups stratified by sex and APOE ε4 genotype. The relationships between cognitive reserve and psychological debt, and between CSF Aβ42 and splenial WMH were stronger in APOE ε4 non-carriers than in carriers (all p ≤ .020).
Conclusions: Cognitive reserve emerges as a key resilience pathway, supporting late-life cognition independently of AD-related pathology, with largely consistent effects across AD risk groups. The role of psychological debt warrants longitudinal investigation, particularly in vulnerable older populations.
Trial registration: German Clinical Trials Register: DRKS00007966, Registered: 4 May 2015.
Supplementary Information: The online version contains supplementary material available at 10.1186/
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9 files
- 2024_Liebscher_DELCODE_M
usicalActivity_and_Brain , R, 108 linesConnectivity/ R_scripts/ 01_matching_procedure.R - 2024_Liebscher_DELCODE_M
usicalActivity_and_Brain , R, 239 linesConnectivity/ R_scripts/ 02_descriptive_statistic s.R - 2024_Liebscher_DELCODE_M
usicalActivity_and_Brain , R, 225 linesConnectivity/ R_scripts/ 03_post_hoc_descriptive_ statistics.R - 2024_Liebscher_DELCODE_M
usicalActivity_and_Brain , R, 132 linesConnectivity/ R_scripts/ 04_local_RSFC_analyses.R - 2024_Liebscher_DELCODE_M
usicalActivity_and_Brain , R, 89 linesConnectivity/ R_scripts/ 05_local_RSFC_plots.R - 2024_Liebscher_DELCODE_M
usicalActivity_and_Brain , R, 148 linesConnectivity/ R_scripts/ 06_global_within_RSFC_an alyses.R - 2024_Liebscher_DELCODE_M
usicalActivity_and_Brain , R, 109 linesConnectivity/ R_scripts/ 07_global_within_RSFC_pl ots.R - 2024_Liebscher_DELCODE_M
usicalActivity_and_Brain , R, 154 linesConnectivity/ R_scripts/ 08_global_between_RSFC_a nalyses.R - 2024_Liebscher_DELCODE_M
usicalActivity_and_Brain , R, 97 lines, 1 matchConnectivity/ R_scripts/ 09_alluvial_plot_musical _activity.R
The paper's code and data availability statement is in the Data section.
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This paper
Boscheck, H., Luft, M., Mauer, R., Senguel, S., D’elia, Y., Dechent, P., Fliessbach, K., Glanz, W., Hetzer, S., Janowitz, D., Kilimann, I., Kleineidam, L., Kronmüller, M., Lüsebrink, F., Preis, L., Rauchmann, B., Rostamzadeh, A., Schott, B. H., Sodenkamp, S., . . . DELCODE study group. (2026). Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers. Alzheimer's research & therapy, 18(1), 93. https://
BibTeX
@article{boscheck2026pat
author = {Boscheck, Hanna and Luft, Maxie and Mauer, René and Senguel, Selin and D’elia, Ylenia and Dechent, Peter and Fliessbach, Klaus and Glanz, Wenzel and Hetzer, Stefan and Janowitz, Daniel and Kilimann, Ingo and Kleineidam, Luca and Kronmüller, Marie and Lüsebrink, Falk and Preis, Lukas and Rauchmann, Boris and Rostamzadeh, Ayda and Schott, Björn Hendrik and Sodenkamp, Sebastian and Spruth, Eike and Stoecklein, Sophia and Yakupov, Renat and Ziegler, Gabriel and Brosseron, Frederic and Buerger, Katharina and Hellmann-Regen, Julian and Laske, Christoph and Perneczky, Robert and Peters, Oliver and Priller, Josef and Ramirez, Alfredo and Schneider, Anja and Spottke, Annika and Teipel, Stefan and Wiltfang, Jens and Jessen, Frank and Düzel, Emrah and Röske, Sandra and Wagner, Michael and Glöckner, Franka and Marchant, Natalie L and Klimecki, Olga and Wirth, Miranka and {DELCODE study group}},
title = {{Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers}},
journal = {Alzheimer's research \& therapy},
year = {2026},
month = apr,
volume = {18},
number = {1},
pages = {93},
publisher = {BMC},
issn = {1758-9193},
doi = {10.1186/
url = {https://
pmid = {42032739},
pmcid = {PMC13107903}
}
RIS
TY - JOUR
AU - Boscheck, Hanna
AU - Luft, Maxie
AU - Mauer, René
AU - Senguel, Selin
AU - D’elia, Ylenia
AU - Dechent, Peter
AU - Fliessbach, Klaus
AU - Glanz, Wenzel
AU - Hetzer, Stefan
AU - Janowitz, Daniel
AU - Kilimann, Ingo
AU - Kleineidam, Luca
AU - Kronmüller, Marie
AU - Lüsebrink, Falk
AU - Preis, Lukas
AU - Rauchmann, Boris
AU - Rostamzadeh, Ayda
AU - Schott, Björn Hendrik
AU - Sodenkamp, Sebastian
AU - Spruth, Eike
AU - Stoecklein, Sophia
AU - Yakupov, Renat
AU - Ziegler, Gabriel
AU - Brosseron, Frederic
AU - Buerger, Katharina
AU - Hellmann-Regen, Julian
AU - Laske, Christoph
AU - Perneczky, Robert
AU - Peters, Oliver
AU - Priller, Josef
AU - Ramirez, Alfredo
AU - Schneider, Anja
AU - Spottke, Annika
AU - Teipel, Stefan
AU - Wiltfang, Jens
AU - Jessen, Frank
AU - Düzel, Emrah
AU - Röske, Sandra
AU - Wagner, Michael
AU - Glöckner, Franka
AU - Marchant, Natalie L
AU - Klimecki, Olga
AU - Wirth, Miranka
AU - DELCODE study group
TI - Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers
T2 - Alzheimer's research & therapy
J2 - Alzheimers Res Ther
PY - 2026
DA - 2026/
VL - 18
IS - 1
SP - 93
SN - 1758-9193
PB - BMC
DO - 10.1186/
UR - https://
LA - en
ER -
CSL-JSON
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Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.
