OSCR

Single cell protein profiling of focal cortical dysplasia in a patient requiring multiple resections.

Overview

Authors: Nada A. Elsayed1,2, Robert P. Naftel3, Bret C. Mobley4, Allyson L. Alexander5,6, Angus M. Toland7, Asa A. Brockman2, Jonathan M. Irish2, Rebecca A. Ihrie2, Kevin C. Ess2
  1. Medical Scientist Training Program, Vanderbilt University School of Medicine,Nashville, TN USA
  2. Department of Pediatrics, Section of Neurology, University of Colorado Anschutz Medical Campus,Aurora, CO USA
  3. Department of Neurosurgery, Vanderbilt University Medical Center,Nashville, TN USA
  4. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center,Nashville, TN USA
  5. Department of Neurosurgery, University of Colorado Anschutz Medical Campus,Aurora, CO USA
  6. Division of Pediatric Neurosurgery, Children’s Hospital Colorado,Aurora, CO 80045 USA
  7. Department of Pathology and Laboratory Services, University of Colorado Anschutz Medical Campus,Aurora, CO USA
Institutions: Vanderbilt University (United States); University of Colorado Anschutz (United States); Vanderbilt University Medical Center (United States); Children's Hospital Colorado (United States)
Journal: Acta neuropathologica communications, volume 14, issue 1, article 97
Dates: received 18 December 2025; accepted 27 February 2026; published online 13 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s40478-026-02273-3 · PMID 41827061 · PMCID PMC13101127 · OpenAlex W7135215860
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), epilepsy (population), cellular / molecular (subfield)
Methods: Smoothing, state filtering, decompositions
Keywords: AKT3, Epilepsy, Focal cortical dysplasia, Gain of function, Mass cytometry
MeSH: Drug Resistant Epilepsy*, Focal Cortical Dysplasia*, Malformations of Cortical Development*, Brain, Female, Humans, Mutation, Proto-Oncogene Proteins c-akt, Single-Cell Analysis (* major topic)
Topic: Epilepsy research and treatment (Psychiatry and Mental health, Medicine), according to OpenAlex
Funding: NIH (T32GM007347, R01CA226833); NINDS (K08NS131572); NINDS (R01NS118580)
Citations: not cited yet (Europe PMC); 34 references in the paper
Research resources: Research Histology Shared Resource RRID:SCR_021994, RRID:SCR_022035

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: Zenodo 17833095
  • it says that the data are available on request

Read it in the paper: doi.org/10.1186/s40478-026-02273-3.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 9 MeSH terms, 3 funders, 33 references, 2 RRIDs.

Cite

This paper

Elsayed, N. A., Naftel, R. P., Mobley, B. C., Alexander, A. L., Toland, A. M., Brockman, A. A., Irish, J. M., Ihrie, R. A., & Ess, K. C. (2026). Single cell protein profiling of focal cortical dysplasia in a patient requiring multiple resections. Acta neuropathologica communications, 14(1), 97. https://doi.org/10.1186/s40478-026-02273-3

BibTeX

@article{elsayed2026single,
author = {Elsayed, Nada A. and Naftel, Robert P. and Mobley, Bret C. and Alexander, Allyson L. and Toland, Angus M. and Brockman, Asa A. and Irish, Jonathan M. and Ihrie, Rebecca A. and Ess, Kevin C.},
title = {{Single cell protein profiling of focal cortical dysplasia in a patient requiring multiple resections}},
journal = {Acta neuropathologica communications},
year = {2026},
month = mar,
volume = {14},
number = {1},
pages = {97},
publisher = {BMC},
issn = {2051-5960},
doi = {10.1186/s40478-026-02273-3},
url = {https://doi.org/10.1186/s40478-026-02273-3},
pmid = {41827061},
pmcid = {PMC13101127}
}

RIS

TY - JOUR
AU - Elsayed, Nada A.
AU - Naftel, Robert P.
AU - Mobley, Bret C.
AU - Alexander, Allyson L.
AU - Toland, Angus M.
AU - Brockman, Asa A.
AU - Irish, Jonathan M.
AU - Ihrie, Rebecca A.
AU - Ess, Kevin C.
TI - Single cell protein profiling of focal cortical dysplasia in a patient requiring multiple resections
T2 - Acta neuropathologica communications
J2 - Acta Neuropathol Commun
PY - 2026
DA - 2026/03/13
VL - 14
IS - 1
SP - 97
SN - 2051-5960
PB - BMC
DO - 10.1186/s40478-026-02273-3
UR - https://doi.org/10.1186/s40478-026-02273-3
LA - en
ER -

CSL-JSON

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